Electrically controlled drug release of donepezil and BiFeO3 magnetic nanoparticle-loaded PVA microbubbles/nanoparticles for the treatment of Alzheimer's disease

Cesur, Sümeyye; Çam, Muhammet Emin; Sayın, Fatih Serdar; Gündüz, Oğuzhan

doi:10.1016/j.jddst.2021.102977

Cited by 21 publications

(12 citation statements)

References 58 publications

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“…The combinations of Bi attributes show an special improvement in exploiting singularly or concomitantly cytotoxicity and diagnostic efficacy (Bartoli et al, 2020 ). For example, the potential of influencing the release of donepezil hydrochloride (DO) through altering the current and voltage in the presence of bismuth ferrite (BiFeO 3 ) results in an highly controllable and delicately tunable medicine release for Alzheimer’s disease treatment (Cesur et al 2022 ). The bismuth tungstate (Bi 2 WO 6 ) nanosheets have developed more opportunities for the rational preparation of novel electronic and biomedical nanosystems.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

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Bismuth (Bi) combinations have been utilized for the treatment of bacterial infections. In addition, these metal compounds are most frequently utilized for treating gastrointestinal diseases. Usually, Bi is found as bismuthinite (Bi sulfide), bismite (Bi oxide), and bismuthite (Bi carbonate). Newly, Bi nanoparticles (BiNP) were produced for CT imaging or photothermal treatment and nanocarriers for medicine transfer. Further benefits, such as increased biocompatibility and specific surface area, are also seen in regular-size BiNPs. Low toxicity and ecologically favorable attributes have generated interest in BiNPs for biomedical approaches. Moreover, BiNPs offer an option for treating multidrug-resistant (MDR) bacteria because they communicate directly with the bacterial cell wall, induce adaptive and inherent immune reactions, generate reactive oxygen compounds, limit biofilm production, and stimulate intracellular impacts. In addition, BiNPs in amalgamation with X-ray therapy as well as have the capability to treat MDR bacteria. BiNPs as photothermal agents can realize the actual antibacterial through continuous efforts of investigators in the near future. In this article, we summarized the properties of BiNPs, and different preparation methods, also reviewed the latest advances in the BiNPs’ performance and their therapeutic effects on various bacterial infections, such as Helicobacter pylori , Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli . Graphical abstract: BiNPs are antibacterial and ideal photothermal agents to inhibit various bacterial infections

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

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“…[ 18 ] For pure PVA (Figure 3A(b)), sharp bands were observed at 3268 cm −1 corresponding to OH stretching, at 1646 cm − 1 CO and CO stretching of the acetate groups, at 2910 cm −1 CH stretching of the alkyl groups, and at 1417 cm −1 CH 2 stretching. [ 36 ] In Figure 3A(c), the peak at 3200 cm −1 is due to the OH stretching in FLU. The presence of a peak at 1620 cm −1 corresponds to CN stretching which indicates the presence of a triazole ring in FLU.…”

Section: Resultsmentioning

confidence: 99%

A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug‐Loaded Nanofibrous Patches

Cesur

Ilhan

Pilavci

et al. 2023

Macro Materials & Eng

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Corneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual‐drug loaded dual‐layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug‐loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug‐loaded layers in one patch. According to drug release results, the FLU and VAN‐loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4'‐6diamidynofenyloindol (DAPI) staining, and 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.

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“…PVA has a semi-crystalline structure due to hydrogen bonding between hydroxyl groups [ 56 ]. For PVA, sharp peaks were observed at 2θ = 38.1° and 44.32° while broad peaks were observed at 2θ = 19.64°, 20.78°, and 22.78° ( Figure 3 B(b)) [ 56 , 57 , 58 ]. Because of its crystalline nature, metformin showed sharp peaks at 17.67°, 22.38°, 23.26°, 24.54°, 29.5°, 31.27°, 37.14°, and 45.86° ( Figure 3 B(c)) [ 51 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Production of 3D Printed Bi-Layer and Tri-Layer Sandwich Scaffolds with Polycaprolactone and Poly (vinyl alcohol)-Metformin towards Diabetic Wound Healing

et al. 2022

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Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by impaired insulin secretion, sensitivity, and hyperglycemia. Diabetic wounds are one of the significant complications of T2DM owing to its difficulty in normal healing, resulting in chronic wounds. In the present work, PCL/PVA, PCL/PVA/PCL, and metformin-loaded, PCL/PVA-Met and PCL/PVA-Met/PCL hybrid scaffolds with different designs were fabricated using 3D printing. The porosity and morphological analysis of 3D-printed scaffolds were performed using scanning electron microscopy (SEM). The scaffolds’ average pore sizes were between 63.6 ± 4.0 and 112.9 ± 3.0 μm. Molecular and chemical interactions between polymers and the drug were investigated with Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). Mechanical, thermal, and degradation analysis of the scaffolds were undertaken to investigate the physico-chemical characteristics of the scaffolds. Owing to the structure, PCL/PVA/PCL sandwich scaffolds had lower degradation rates than the bi-layer scaffolds. The drug release of the metformin-loaded scaffolds was evaluated with UV spectrometry, and the biocompatibility of the scaffolds on fibroblast cells was determined by cell culture analysis. The drug release in the PCL/PVA-Met scaffold was sustained till six days, whereas in the PCL/PVA-Met/PCL, it continued for 31 days. In the study of drug release kinetics, PCL/PVA-Met and PCL/PVA-Met/PCL scaffolds showed the highest correlation coefficients (R2) values for the first-order release model at 0.8735 and 0.889, respectively. Since the layered structures in the literature are mainly obtained with the electrospun fiber structures, these biocompatible sandwich scaffolds, produced for the first time with 3D-printing technology, may offer an alternative to existing drug delivery systems and may be a promising candidate for enhancing diabetic wound healing.

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Electrically controlled drug release of donepezil and BiFeO3 magnetic nanoparticle-loaded PVA microbubbles/nanoparticles for the treatment of Alzheimer's disease

Cited by 21 publications

References 58 publications

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug‐Loaded Nanofibrous Patches

Production of 3D Printed Bi-Layer and Tri-Layer Sandwich Scaffolds with Polycaprolactone and Poly (vinyl alcohol)-Metformin towards Diabetic Wound Healing

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