Electrically controlled release of sulfosalicylic acid from crosslinked poly(vinyl alcohol) hydrogel

Juntanon, Kanokporn; Niamlang, Sumonman; Rujiravanit, Ratana; Sirivat, Anuvat

doi:10.1016/j.ijpharm.2007.12.023

Cited by 82 publications

(72 citation statements)

References 38 publications

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“…Ryan F. Donnelly and Juntanon et al [60][61][62][63] realized that MNs had the possibility to carry microorganisms into the skin and did related tests which indicated that microorganisms could penetrate skin beyond the stratum corneum following microneedle puncture. The numbers of microorganisms crossing the stratum corneum following microneedle puncture were greater than 10 5 cfu in each case while no microorganisms crossed the epidermal skin.…”

Section: Existing Problems Of Hydrogel Mnsmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hong

Chen

et al. 2014

Nano-Micro Lett

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Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms. In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

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Section: Existing Problems Of Hydrogel Mnsmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hong

Chen

et al. 2014

Nano-Micro Lett

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“…To prevent the formation of air bubbles, the solution was mixed very slowly. After mixing the solution, the mixture was dry cast on a mold (diameter of 9 cm) directly, then dried in a dust-free atmosphere at 60°C for 3 h, and finally cooled to room temperature (10,11).…”

Section: Preparation Of Drug-loaded Pva Hydrogelsmentioning

confidence: 99%

“…The other electrode was placed elsewhere in the acetate buffer. Samples were prepared from frozen swollen hydrogels with and without an electric field in liquid nitrogen and dried in a vacuum at −50°C (11,12).…”

Section: Pva Hydrogel Charaterizationmentioning

confidence: 99%

“…Glacial acetic acid (15 ml) was added to the aqueous sodium acetate solution, and the total volume was adjusted with distilled water to 1,000 ml (11).…”

Section: Preparation Of Acetate Buffermentioning

confidence: 99%

“…The characteristic UV absorbance peaks of benzoic acid and sulphanilamide that were used for identifications were at 234 and 260 nm, respectively. The model drug concentrations were calculated from the calibration curves between the UV peaks and the model drug concentration (11).…”

Section: Spectrophotometer Analysis Of Model Drugmentioning

confidence: 99%

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Electric Field-Controlled Benzoic Acid and Sulphanilamide Delivery from Poly(Vinyl Alcohol) Hydrogel

et al. 2012

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Abstract. The controlled release of benzoic acid (3.31 Å) and sulphanilamide (3.47 Å) from poly(vinyl alcohol), PVA, hydrogels fabricated by solution casting at various cross-linking ratios, were investigated. The PVA hydrogels were characterized in terms of the degree of swelling, the molecular weight between cross-links, and the mesh size. The drug release experiment was carried out using a modified Franz diffusion cell, at a pH value of 5.5 and at temperature of 37°C. The amount of drug release and the diffusion coefficients of the drugs from the PVA hydrogels increased with decreasing cross-linking ratio, as a larger mesh size was obtained with lower cross-linking ratios. With the application of an electric field, the amount of drug release and the diffusion coefficient increased monotonically with increasing electric field strength, since the resultant electrostatic force drove the ionic drugs from the PVA matrix. The drug size, matrix pore size, electrode polarity, and applied electric field were shown to be influential controlling factors for the drug release rate.

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Poly(vinyl alcohol)

Fink¹

2011

Handbook of Engineering and Specialty Thermoplastics

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Electrically controlled release of sulfosalicylic acid from crosslinked poly(vinyl alcohol) hydrogel

Cited by 82 publications

References 38 publications

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Electric Field-Controlled Benzoic Acid and Sulphanilamide Delivery from Poly(Vinyl Alcohol) Hydrogel

Poly(vinyl alcohol)

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