Electrically Evoked Auditory Brainstem Response by Using Bionic Auditory Membrane in Guinea Pigs

Shintaku, Hirofumi; Inaoka, Takatoshi; Nakagawa, Takayuki; Ito, Juichi

doi:10.1299/jbse.8.198

Cited by 12 publications

(21 citation statements)

References 22 publications

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“…In addition, the resonance frequency and off‐resonance frequency sound were applied to a certain channel of the ABM to evaluate frequency selectivity. As the ABM cannot generate sufficient electricity at the off‐resonance frequency sound, the amplitude of the eABR was recorded as noise level . These experiments validated the cochlear tonotopy of the ABMs using a deafened animal model.…”

Section: Characterization Of the Abm Using Animal Modelsmentioning

confidence: 73%

“…There are two approaches to animal testing using ABMs, depending on the target position for implantation. In studies attempting to implant the ABMs into the ear canal or middle ear cavity, the ABMs were used as acoustic sensors for recording the auditory evoked potential in animal models using an additional signal processor and electrode array . For intracochlear ABMs, the ABM is inserted into the cochlea of the animal model and the frequency selectivity is evaluated in the cochlea …”

Section: Characterization Of the Abm Using Animal Modelsmentioning

confidence: 99%

“…Studies evaluating the performance of ABMs by recording the eABR from deafened guinea pigs were performed using PVDF membrane‐type ABMs, AlN cantilever array ABMs, and TEABMs . Figure a shows schematic illustrations of the animal test performed using the AlN cantilever‐type ABM, as reported by Jang et al When the acoustic stimulus is applied to the ABM by a loudspeaker, the ABM generates piezoelectric output depending on the SPL and the sound frequency.…”

Section: Characterization Of the Abm Using Animal Modelsmentioning

confidence: 99%

“…Recent advances in ABMs have been made through in vivo experiments in which ABMs were applied to animal models. The auditory brainstem response (ABR) from deafened guinea pigs were measured using the electrical output induced by the ABM under sound pressure . Another approach involves implantation of the ABM into the cochlea followed by evaluation of its tonotopic characteristics .…”

Section: Introductionmentioning

confidence: 99%

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Biomimetic Artificial Basilar Membranes for Next‐Generation Cochlear Implants

Jang

Choi

2017

Adv Healthcare Materials

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Patients with sensorineural hearing loss can recover their hearing using a cochlear implant (CI). However, there is a need to develop next-generation CIs to overcome the limitations of conventional CIs caused by extracorporeal devices. Recently, artificial basilar membranes (ABMs) are actively studied for next-generation CIs. The ABM is an acoustic transducer that mimics the mechanical frequency selectivity of the BM and acoustic-to-electrical energy conversion of hair cells. This paper presents recent progress in biomimetic ABMs. First, the characteristics of frequency selectivity of the ABMs by the trapezoidal membrane and beam array are addressed. Second, to reflect the latest research of energy conversion technologies, ABMs using various piezoelectric materials and triboelectric-based ABMs are discussed. Third, in vivo evaluations of the ABMs in animal models are discussed according to the target position for implantation. Finally, future perspectives of ABM studies for the development of practical hearing devices are discussed.

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Section: Characterization Of the Abm Using Animal Modelsmentioning

confidence: 73%

Section: Characterization Of the Abm Using Animal Modelsmentioning

confidence: 99%

Section: Characterization Of the Abm Using Animal Modelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomimetic Artificial Basilar Membranes for Next‐Generation Cochlear Implants

Jang

Choi

2017

Adv Healthcare Materials

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“…Measurements of electrically EABRs were performed as described in previous studies (Hall, 1990b; Ogita et al, 2009; Shintaku et al, 2013). Briefly, we used a conventional retroauricular approach with the animal in a lateral recumbent position.…”

Section: Methodsmentioning

confidence: 99%

A hardware model of the auditory periphery to transduce acoustic signals into neural activity

et al. 2013

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To improve the performance of cochlear implants, we have integrated a microdevice into a model of the auditory periphery with the goal of creating a microprocessor. We constructed an artificial peripheral auditory system using a hybrid model in which polyvinylidene difluoride was used as a piezoelectric sensor to convert mechanical stimuli into electric signals. To produce frequency selectivity, the slit on a stainless steel base plate was designed such that the local resonance frequency of the membrane over the slit reflected the transfer function. In the acoustic sensor, electric signals were generated based on the piezoelectric effect from local stress in the membrane. The electrodes on the resonating plate produced relatively large electric output signals. The signals were fed into a computer model that mimicked some functions of inner hair cells, inner hair cell–auditory nerve synapses, and auditory nerve fibers. In general, the responses of the model to pure-tone burst and complex stimuli accurately represented the discharge rates of high-spontaneous-rate auditory nerve fibers across a range of frequencies greater than 1 kHz and middle to high sound pressure levels. Thus, the model provides a tool to understand information processing in the peripheral auditory system and a basic design for connecting artificial acoustic sensors to the peripheral auditory nervous system. Finally, we discuss the need for stimulus control with an appropriate model of the auditory periphery based on auditory brainstem responses that were electrically evoked by different temporal pulse patterns with the same pulse number.

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Flexible Inorganic Piezoelectric Acoustic Nanosensors for Biomimetic Artificial Hair Cells

Lee

Chung

Hwang

et al. 2014

Adv Funct Materials

211

163

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For patients who suffer from sensorineural hearing loss by damaged or loss of hair cells in the cochlea, biomimetic artificial cochleas to remedy the disadvantages of existing implant systems have been intensively studied. Here, a new concept of an inorganic‐based piezoelectric acoustic nanosensor (iPANS) for the purpose of a biomimetic artificial hair cell to mimic the functions of the original human hair cells is introduced. A trapezoidal silicone‐based membrane (SM) mimics the function of the natural basilar membrane for frequency selectivity, and a flexible iPANS is fabricated on the SM utilizing a laser lift‐off technology to overcome the brittle characteristics of inorganic piezoelectric materials. The vibration amplitude vs piezoelectric sensing signals are theoretically examined based on the experimental conditions by finite element analysis. The SM is successful at separating the audible frequency range of incoming sound, vibrating distinctively according to varying locations of different sound frequencies, thus allowing iPANS to convert tiny vibration displacement of ≈15 nm into an electrical sensing output of ≈55 μV, which is close to the simulation results presented. This conceptual iPANS of flexible inorganic piezoelectric materials sheds light on the new fields of nature‐inspired biomimetic systems using inherently high piezoelectric charge constants.

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Electrically Evoked Auditory Brainstem Response by Using Bionic Auditory Membrane in Guinea Pigs

Cited by 12 publications

References 22 publications

Biomimetic Artificial Basilar Membranes for Next‐Generation Cochlear Implants

Biomimetic Artificial Basilar Membranes for Next‐Generation Cochlear Implants

A hardware model of the auditory periphery to transduce acoustic signals into neural activity

Flexible Inorganic Piezoelectric Acoustic Nanosensors for Biomimetic Artificial Hair Cells

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