Electricians’ chrysotile asbestos exposure from electrical products and risks of mesothelioma and lung cancer

Goodman, Julie E.; Peterson, Michael K.; Bailey, Lisa A.; Kerper, Laura E.; Dodge, David G.

doi:10.1016/j.yrtph.2013.10.008

Cited by 12 publications

(5 citation statements)

References 72 publications

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“…However, the levels of such exposure are not expected to exceed the current occupational exposure limits for asbestos of 0.1 f/ml as an 8-hr TWA or 1.0 f/ml averaged over a 30-minute exposure period. This exposure analysis is consistent with a recent assessment of cancer risk among electricians that concluded exposure to chrysotile in electrical products is well below the OSHA permissible exposure limit and does not increase the risk of lung cancer and mesothelioma (7). In addition, this investigation demonstrates the importance of TEM adjustment of PCM findings to accurately characterize asbestos and non-asbestos form fibers in the work environment.…”

Section: Resultssupporting

confidence: 88%

Power Stripping of Asbestos-Containing Insulation from Electrical Cable

Blake¹,

Johnson²,

Harbison³

2019

ODEM

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Efforts to recycle copper from electrical conductors have led to the development of specialized machines, which automatically remove insulating covers from wires and cable products. In the past, certain wire and cable products were insulated using chrysotile asbestos. This research was undertaken to determine the asbestos fiber exposure risks associated with power stripping machinery to remove asbestos-containing insulation materials from electrical wire or cable. A Rigby Machinery, Inc., Model 4H electric powered wire/cable insulation stripping machine was acquired along with approximately 42 m of asbestos insulated cable. During two separate, but nearly identical, test sessions, a laborer used the wire stripper to remove the asbestos-containing insulation from the subject cable. This work took place within a closed metal building with a total interior volume of 2500 m 3 . Industrial hygiene personal and area air samples were collected for airborne fibers throughout all wire stripping periods. Collected air samples were analyzed using phase contract microscopy (PCM) and transmission microscopy (TEM). The results of analysis using PCM for personal samples (n = 3) taken during periods of continuous cable stripping activity showed test period airborne fiber exposures ranging from 0.034 to 0.068 (mean 0.056 f/cc). Follow-up analysis of these personal samples using TEM indicated asbestos adjusted PCM exposures ranging from 0.017 to 0.045 (mean 0.033 f/cc). Area air samples taken at distances ranging from 2 to 9 meters from the wire stripper (n = 16) showed asbestos adjusted PCM concentrations ranging from less than 0.0001 to 0.041 f/cc (mean 0.007 f/cc). The process of power stripping asbestos-containing insulation from electrical wires and cables can cause exposure to airborne asbestos fibers. However, the levels of such exposure are not expected to exceed the current occupational exposure limits for asbestos of 0.1 f/cc as an 8-hr TWA or 1.0 f/cc averaged over a 30-minute exposure period.

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Section: Resultssupporting

confidence: 88%

Power Stripping of Asbestos-Containing Insulation from Electrical Cable

Blake¹,

Johnson²,

Harbison³

2019

ODEM

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“…[8] [9][10]. This supposition is consistent with the lack of epidemiological evidence for enhanced asbestos-related disease among multiple occupational cohorts[9] [11][12].…”

supporting

confidence: 65%

Evaluation of Asbestos Exposure Associated with Research Laboratories

Garcia¹,

Newfang²,

Coyle³

et al. 2019

ODEM

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Asbestos containing materials (ACM) have been used for decades in research laboratory products including gloves, tong sleeves, Transite board, and other materials. These materials typically contain chrysotile asbestos with concentrations ranging up to 80%. The objective of this research was to evaluate asbestos exposure from gloves, tong sleeves, and Transite board with simulated laboratory use. An environmental chamber was used to simulate laboratory application of the products. Bulk samples of various products were tested before and after use. Personal breathing zone air samples as well as one cumulative air sample were collected during testing and followed the National Institute for Occupational Safety and Health (NIOSH) 7400/7402 methodologies. Phase contrast microscopy (PCM) and transmission electron microscopy (TEM) were used for sample analyses. Analysis of air samples using PCM, showed airborne fiber concentrations as high as 0.058 f/cc during use of tongs fitted with asbestos sleeves. Further analysis using TEM showed that the highest airborne fiber concentration was 0.0036 f/cc. Manipulation of Transite board resulted in 8-hour time-weighted-average (TWA) asbestos levels as high as 0.02 f/cc. Testing of various asbestos containing materials used in research laboratories indicate low potential for asbestos fiber exposures.

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“…Some studies have shown that there is no detectable health risk of chrysotile asbestos exposed to low doses (Bernstein, et al,2013). There are also reports showing that even high-dose chrysotile exposure has only a low risk (Goodman, et al,2014). The preliminary results of this research group showed that low-dose chrysotile asbestos exposure can induce malignant transformation of MeT-5A cells and obtain the biological characteristics of mesothelioma cells.…”

Section: Disscussionmentioning

confidence: 75%

A nontoxic dose of chrysotile induces a malignant phenotype tendency of human pleural mesothelial cells MeT-5A, short- term and long-term exposures induce different features of ROS

Yuan,

Zhang,

et al. 2023

Preprint

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Chrysotile products are widely used in daily life, and a large amount of inhalable dust can be generated during the production process. At present, there is still controversy in the international community about the safety of chrysotile fibers, and it is not clear whether inhalation of chrysotile dust will cause mesothelioma. In our study, a lower dose(5µg/cm2) of chrysotile was used to explore the toxicity of short-term and long-term exposure to chrysotile asbestos. In this study, three time points of short-term exposure (24h, 48h, 72h) and long-term exposure of 28w were selected to infect human mesothelial cells MeT-5A to detect the malignant phenotypic changes, including cells proliferation, migration, invasion, cycle and apoptosis levels, as well as changes in reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), to evaluate the carcinogenicity of chrysotile and its molecular mechanism in the carcinogenic process of mesothelioma. The results showed that MeT-5A cells showed a certain degree of malignant phenotype after short-term exposure to chrysotile. After 28 weeks of long-term exposure, the cells were anchor-independent manner, and transformed cells (Asb-T MeT-5A) were successfully established. In addition, the CCK-8 experiment was used to detect the cell proliferation ability, and the scratch experimentand Transwell were used to evaluate the cell migration and invasion ability. Flow cytometry is used to detect cell cycle and apoptosis, and flow cytometry is used to detect cell ROS and MMP. The results showed that the migration and invasion capabilities of MeT-5A cells exposed to short-term exposure were significantly enhanced (p < 0.05). The number of cells in G1 was significantly lower than that of the control group, but the number of apoptotic cells was significantly higher than that of the control group. Through the transformation of chrysotile, the proliferation, migration and invasion ability of Asb-T MeT-5A cells was significantly enhanced (p < 0.01). The results of flow cytometry showed that the number of cells in G1 in the Asb-T MeT-5A group was significantly lower than that of the control group,and the number of apoptotic cells in the Asb-T MeT-5A group was significantly lower than that of the control group. ROS and MMP level detection results showed that the ROS level of MeT-5A cells exposed to short-term exposure increased, while the ROS of transformed cells Asb-T MeT-5A decreased. The results of the MMP of cells treated at different times were consistent, all showed increasing trend (p < 0.05). Chrysotile can induce the malignant transformation of MeT-5A cells, enhance the proliferation, migration and invasion ability of MeT-5A cells, and reduce the number of G1 phase and apoptotic cells. Chrysotile asbestos can change the ROS and membrane potential levels of MeT-5A cells.

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Electricians’ chrysotile asbestos exposure from electrical products and risks of mesothelioma and lung cancer

Cited by 12 publications

References 72 publications

Power Stripping of Asbestos-Containing Insulation from Electrical Cable

Power Stripping of Asbestos-Containing Insulation from Electrical Cable

Evaluation of Asbestos Exposure Associated with Research Laboratories

A nontoxic dose of chrysotile induces a malignant phenotype tendency of human pleural mesothelial cells MeT-5A, short- term and long-term exposures induce different features of ROS

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