Electro‐acupuncture at <scp>ST</scp>37 and <scp>ST</scp>25 induce different effects on colonic motility via the enteric nervous system by affecting excitatory and inhibitory neurons

Chaochao, Liang; Wang, K.-Y.; Gong, Meirong; Li, Q.; Yu, Zhi; Xu, Bin

doi:10.1111/nmo.13318

Cited by 43 publications

(31 citation statements)

References 33 publications

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“…When it comes to colonic motility, the situation is a bit more complicated, because the effects of acupoints located in different areas on the proximal and distal colon are inconsistent. Acupuncture at the acupoints of the forelimb (LI1–LI6 and LI11), abdomen (ST25), and back (BL25) had no significant effects on the proximal colonic motility; and acupoints of the hind paw (ST37) increased proximal colonic pressure[ 70 - 72 ]. Stimulation of the limbs (LI11, ST37, and ST36), abdomen (ST25), and back (ST37) all produced an augmented effect on distal colonic motility regardless of normal, constipated, or diarrheic state[ 73 ].…”

Section: Autonomic Nervous System Mechanism Of Acupuncturementioning

confidence: 99%

“…Further results indicated the restoration of enteric neuron function by downregulating the level of nitric oxide synthase (nNOS, secreted by inhibitory neurons to induce relaxation) and upregulating the expression of choline acetyltransferase (ChAT, secreted by excitatory neurons to induce contraction). While ST25, located in the abdomen, could only downregulate the expression of nNOS; therefore, the regulatory effect of EA on enteric neurons seems to act in a region-specific manner[ 72 ] (Figure 2 ).…”

Section: Ens Mechanism Of Acupuncturementioning

confidence: 99%

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Neuromechanism of acupuncture regulating gastrointestinal motility

Yu¹

2020

WJG

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Acupuncture has been used in China for thousands of years and has become more widely accepted by doctors and patients around the world. A large number of clinical studies and animal experiments have confirmed that acupuncture has a benign adjustment effect on gastrointestinal (GI) movement; however, the mechanism of this effect is unclear, especially in terms of neural mechanisms, and there are still many areas that require further exploration. This article reviews the recent data on the neural mechanism of acupuncture on GI movements. We summarize the neural mechanism of acupuncture on GI movement from four aspects: acupuncture signal transmission, the sympathetic and parasympathetic nervous system, the enteric nervous system, and the central nervous system.

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Section: Autonomic Nervous System Mechanism Of Acupuncturementioning

confidence: 99%

Section: Ens Mechanism Of Acupuncturementioning

confidence: 99%

Neuromechanism of acupuncture regulating gastrointestinal motility

Yu¹

2020

WJG

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“…However, much less is known on the EA mechanisms involving the enteric nervous system. In one previous study, EA was found to enhance enteric neurons 36 ; in the article published in this issue, 37 EA was found to regulate inhibitory and excitatory neurons in the enteric nervous system. More studies are needed to explore EA mechanisms involving the enteric nerves.…”

Section: Mechanis Ms Of Elec Troacupun C Turementioning

confidence: 79%

Electroacupuncture treatments for gut motility disorders

Chen¹,

Yin³

2018

Neurogastroenterology Motil

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Functional gastrointestinal (GI) diseases are common and there are patients who are refractory to medical therapies as not all treatments work in all patients. Consequently, a large number of patients with functional GI diseases use complementary and alternative medicine, such as acupuncture or electroacupuncture (EA). In this issue, Zheng et al. reported interesting results of a multi-center placebo-controlled clinical study on the use of EA for treating refractory functional dyspepsia; another study reported a multi-center clinical trial on EA for chronic functional constipation; Liang et al. studied mechanisms of EA involving enteric nervous system and neurotransmitters in treating constipation in rats. While controversial reports are available in the literature, EA with appropriate methodologies as shown in these recent studies is believed to be effective in treating certain functional GI diseases. In this mini-review, a number of clinical studies, including those included in this issue on the use of EA for treating gastro-esophageal reflux, functional dyspepsia, irritable bowel syndrome, and constipation are reviewed. Some critically important issues, such as the choice of stimulation parameters for EA, the administration frequency of the therapy, and the appropriate choice of placebo for clinical research are also discussed. Mechanisms of action involved in the therapeutic effects of EA for gut dysmotility and future research directions are also presented.

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“…This implied that the relaxation and contraction function of intestinal muscles is weakened by HFD; the prolonged time for nutrient absorption enables excessive energy harvest and consequently obesity. Our results displayed that electroacupuncture can improve intestinal motility by modulating excitatory and inhibitory ENS neurons, which coordinate the contraction and relaxation muscles, and orchestrate the central nervous system and ENS [26]. Electroacupuncture treatment ameliorated the pathological ENS conditions in the obese mice by increasing ITR and modulating serum neurotransmitters.…”

Section: Discussionmentioning

confidence: 97%

Regulating the Enteric Nervous System against Obesity in Mice by Electroacupuncture

Ding

Chen

Zhong

et al. 2020

Neuroimmunomodulation

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Background and Objectives: The enteric nervous system (ENS) dominates the onset of obesity and has been shown to regulate nutrient absorption and energy metabolism. Methods and Study Design: This study was performed to investigate the role of electroacupuncture in regulating ENS function in obese mice. Obese mice were obtained by highfat diet. 16S rRNA pyrosequencing, Western blotting, quantitative PCR, and neurotransmitter analysis were used for this purpose. Results: Body weight, Lee index, serum lipid, leptin, and adiponectin levels, and other basic indices were significantly ameliorated after electroacupuncture intervention. The pathological ENS scores, serum neurotransmitter levels, and intestinal transit rate were markedly changed in obese mice. Moreover, electroacupuncture promoted the diversity of gut microbiota. No significant differences were observed 21 and 28 days after electroacupuncture. Conclusions: These results suggested ENS may be a new treatment approach to obesity.

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Electro‐acupuncture at ST37 and ST25 induce different effects on colonic motility via the enteric nervous system by affecting excitatory and inhibitory neurons

Cited by 43 publications

References 33 publications

Neuromechanism of acupuncture regulating gastrointestinal motility

Neuromechanism of acupuncture regulating gastrointestinal motility

Electroacupuncture treatments for gut motility disorders

Regulating the Enteric Nervous System against Obesity in Mice by Electroacupuncture

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