Electro-generated base from amide derivative enables cyclopropanation of alkyl 2-chloroacetate without formation of trialkyl propane-1,2,3-carboxylate

Abstract

Electro-generated base was found to be quite effective for the formation of cyclopropane derivatives from alkyl 2-chloroacetates in good yields, without the formation of trialkyl propane-1,2,3-carboxylate of the inseparable by-product. The reaction optimization for electro-generated bases as well as scope and limitations were conducted for the current report.