Electro-metabolic coupling in atrial fibrillation: A deeper understanding of the metabolic driver

Qin, Xinghua; Jin, Lingyan; Gong, Haoyu; Zheng, Qiangsun

doi:10.1016/j.biopha.2024.117536

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117536

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Electro-metabolic coupling in atrial fibrillation: A deeper understanding of the metabolic driver

Xinghua Qin,

Lingyan Jin,

Haoyu Gong

et al.

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2024

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Cited by 1 publication

References 110 publications

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Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment

Rohun,

Dudzik,

Raczak-Gutknecht

et al. 2024

JCM

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Background/Objectives: Atrial fibrillation (AF) is the most frequent arrhythmia in the adult population associated with a high rate of severe consequences leading to significant morbidity and mortality worldwide. Therefore, its prompt recognition is of high clinical importance. AF detection often remains challenging due to unspecific symptoms and a lack of reliable biomarkers for its prediction. Herein, novel bioanalytical methodologies, such as metabolomics, offer new opportunities for a better understanding of the underlying pathological mechanisms of cardiovascular diseases, including AF. The metabolome, considered a complete set of small molecules present in the organism, directly reflects the current phenotype of the studied system and is highly sensitive to any changes, including arrhythmia’s onset. A growing body of evidence suggests that metabolite profiling has prognostic value in AF prediction, highlighting its potential role not only in early diagnosis but also in guiding therapeutic interventions. By identifying specific metabolites as a disease biomarker or recognising particular metabolomic pathways involved in the AF pathomechanisms, metabolomics could be of great clinical value for further clinical decision-making, risk stratification, and an individual personalised approach. The presented narrative review aims to summarise the current state of knowledge on metabolomics in AF with a special emphasis on its implications for clinical practice and personalised medicine.

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Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment

Rohun,

Dudzik,

Raczak-Gutknecht

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

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Electro-metabolic coupling in atrial fibrillation: A deeper understanding of the metabolic driver

Cited by 1 publication

References 110 publications

Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment

Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment

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