Electro-organic green synthesis of dicyano-2-(2-oxoindolin-3-ylidene) malononitriles using molecular iodine as catalyst

Abstract

The first electrochemical molecular iodine promoted, domino reactions for the green synthesis of biologically relevant dicyano 2-(2-oxoindolin-3-ylidene) malononitriles from readily available isatin derivatives and malononitrileat room temperature has been presented.

Electrochemical and photochemical reaction of isatins: a decade update

“…In 2023, Malviya and Sagar's group 18 synthesised isatylidene malononitrile using three chemical components i.e. , isatin 1 , malononitrile 6b , and iodine in ethanol as solvent (Scheme 9).…”

Electro-organic synthesis of isatins and hydrazones through C–N cross-coupling and C(sp2)–H/C(sp3)–H functionalization

“…In our continuous effort towards the electro-organic synthesis of small molecules, 14 in this communication, we report a greener synthesis of isatins and their respective hydrazones in good to excellent yields using an electro-organic synthetic approach through C–N cross-coupling and C(sp 2 )–H/C(sp 3 )–H functionalization (Fig. 1).…”