Nanometric particles with base liquids cause the production of nanofluids, which are distinguished by their outstanding thermally conductive fluid properties and the expansion of electrical and mechanical devices. Based on these considerations, we devised a study to investigate the effect of activation energy on the peristaltic motion of Carreau nanofluid inside a curved asymmetric channel under the influence of a magnetic field. The governing equations for the curved channel of non-Newtonian fluid flow are formulated. The nonlinear partial differential equations system has been reduced to ordinary differential equations by the assumptions of low Reynolds number and long wavelength approximations. The resulting nonlinear coupled differential equations are numerically solved directly using NDSolve (numerical differential equation solver) coding of computational mathematical software Mathematica, and velocity, temperature, concentration, and streamlines are plotted. With graphical demonstrations, the influence of essential parameters on velocity, temperature, concentration, and streamlines is explained in detail. The dimensionless temperature distribution grows as the activation energy parameter grows. In reality, the number of energetic particles (with energies equal to or greater than activation energy) increases, resulting in improved temperature distribution.