Electro‐oxidation and Determination of Tripelennamine Hydrochloride at MWCNT‐CTAB Modified Glassy Carbon Electrode

Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm 2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k 0) was obtained to be 1.332× 10 3 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.

show abstract

“…There are two tertiary amines present in the molecule. The electro oxidation takes place at tertiary amine attached to pyridine ring [23].…”

Section: Mechanismmentioning

confidence: 99%

Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode

Gowda¹,

Hanabaratti²,

Nandibewoor³

2019

SJAC

View full text Add to dashboard Cite

show abstract

“…TRP is official in USP 40 [2]. Methods of assay of TRP include spectrophotometric [3], chromatographic [4][5][6][7][8], electrochemical [9,10], and electrophoretic methods [11,12]. All reported chromatographic methods for the assay of TRP have many system suitability problems such as fronted peak with long runtime and needing gradient elution [6] or not well separated [4,7] or need the addition of another reagent for detection [7] or tailed peaks [5].…”

Section: Introductionmentioning

confidence: 99%

Green micellar liquid chromatographic method for simultaneous determination of antihistaminic drugs tripelennamine hydrochloride and diphenhydramine in pharmaceutical gel

Hammad,

El‐Malla,

El‐Khateeb

2024

J of Separation Science

View full text Add to dashboard Cite

A new green micellar liquid chromatographic method has been developed and validated for the simultaneous determination of diphenhydramine (DPH) and tripelennamine hydrochloride (TRP) using a micellar mobile phase consisting of 1 mM Tween 20 in phosphate buffer pH 4:isopropanol (85:15, %v/v). The method was linear in the range of 4–150 and 5–120 μg/mL for TRP and DPH, respectively. The method was successfully applied for the simultaneous determination of DPH and TRP in a laboratory‐prepared gel containing all possible excipients with mean percent recoveries ± standard deviation of 100.346 ± 1.265 and 100.754 ± 1.117 for TRP and DPH, respectively. The method was validated according to the International Conference on Harmonization guidelines. The method is confirmed to have excellent greenness.

show abstract

“…[19][20] The glassy carbon electrode (GCE) is a convenient conductive matrix having a specific surface orientation, wide operational window, selectivity and sensitivity in the results, good mechanical property, and easy surface modification. [21][22] However, the unmodified GCE does not shows significant and selective separation of electroactive isomers, [23] biomolecules in presence of interferences, [24][25] pharmaceutical drugs [26][27] and neurotransmitter's. [28] Therefore, electrode modification with special conductive layers has been the new trend identified by electrochemical researchers in order to overcome this drawback.…”

Section: Introductionmentioning

confidence: 99%

Interference Free Simultaneous Detection of Dihydroxy Benzene Isomers at Cost‐effective and Reliable Celestine Blue Modified Glassy Carbon Electrode

et al. 2021

View full text Add to dashboard Cite

A successful cyclic voltammetric electropolymerisation and electrochemical characterization of celestine blue (CB) was achieved on glassy carbon electrode (GCE). The fabricated electrode was then used for the electroanalysis of hydroquinone (HQ) and catechol (CC). Due to the improved electrocatalytic activity of the fabricated electrode, an interference free simultaneous detection of CC by HQ was observed. The scan rate studies suggest the diffusion‐controlled kinetics phenomenon at the modified electrode. Concentration studies, yielding a limit of detection (LoD) of 0.0491 μM and 0.0456 μM for CC and HQ respectively in the first linear range of 0 to 40 μM, limit of detection of 0.0621 μM and 0.0638 μM for CC and HQ respectively in the second linear range of 50 to 120 μM, which were relatively lower as compared to previous reports was achieved by using differential pulse voltammetry (DPV). In order to evaluate the analytical performance of the CB/GCE, tap water sample analysis was carried out and good recovery results were obtained.

show abstract

Electro‐oxidation and Determination of Tripelennamine Hydrochloride at MWCNT‐CTAB Modified Glassy Carbon Electrode

Cited by 8 publications

References 48 publications

Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode

Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode

Green micellar liquid chromatographic method for simultaneous determination of antihistaminic drugs tripelennamine hydrochloride and diphenhydramine in pharmaceutical gel

Interference Free Simultaneous Detection of Dihydroxy Benzene Isomers at Cost‐effective and Reliable Celestine Blue Modified Glassy Carbon Electrode

Contact Info

Product

Resources

About