Electro-oxidation induced O–S cross-coupling of quinoxalinones with sodium sulfinates for synthesizing 2-sulfonyloxylated quinoxalines

Abstract

The novel C2–O sulfonylation of quinoxalinones via electro-oxidation induced O–S coupling strategy under mild conditions was reported.

Metal-free sulfonylation of quinoxalinones to access 2-sulfonyl-oxylated quinoxalines via oxidative O–S cross coupling

“…6 Therefore, the C2 transformation of quinoxalinones is still highly desirable via simple, mild, efficient, and metal-free strategies. Given the research interests in oxidative cross-coupling reactions, 7 to overcome challenges in oxidative O–S coupling and diversify the oxidative O–S coupling mechanism, 7 b we established a facile and efficient oxidative O–S cross-coupling strategy for synthesizing 2-sulfonyloxylated quinoxalines starting from quinoxalinones and sodium sulfinates (Scheme 1b).…”

Cobalt‐Catalyzed Annulation of o‐Phenylenediamines and Internal Alkynes: Efficient Synthesis of Quinoxaline Derivatives

“…Recently, various strategies including transition-metalcatalysis, [8] transition-metal-free catalysis, [9] electrochemical synthesis, [10] and Co-catalysis, [11] have been developed to access to quinoxalines. Among these strategies, one of the most common and effective methods to construct quinoxaline is the condensation reaction between o-phenylenediamines and dicarbonyl compounds.…”