Electro-oxidation of carbamazepine metabolites: Characterization and influence in the voltammetric determination of the parent drug

Teixeira, Jorge Ginja; Veiga, Alfredina; Carvalho, A.J. Palace; Teixeira, Dora Martins

doi:10.1016/j.electacta.2013.06.070

Cited by 26 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They were 0.588 and 0.109 µg/L for HDX-CBZ and EPX-CBZ, respectively. Compared to the reported study by (Teixeira et al 2013), the limits of quanti cation ranged between 25.9 and 39.0 µg/L, which is higher than the LOQs reported in the present study. The reason is related to the type of instrument used for method validation.…”

Section: Methods Validationcontrasting

confidence: 94%

See 1 more Smart Citation

Electrochemical Degradation of Carbamazepine: A Case Study of Quantification of “10, 11 Dihydro-10 Hydroxy Carbamazepine And 10, 11-Epoxycarbamazepine” As The Main By-Products Using LC-TOF/MS.

Mussa

Al-Qaim

2021

Preprint

View full text Add to dashboard Cite

Carbamazepine (CBZ) is one of the most widely used antiepileptic drugs in Malaysia, so, it was detected in wastewater frequently. The electrochemical treatment process has been applied for the degradation of CBZ using graphite-PVC as an anode. However, two main by-products, namely, 10,11-dihydro10-hydroxy carbamazepine (HDX-CBZ) and 10,11-epoxycarbamazepine (EPX-CBZ) have been analysed and quantified using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). HDX-CBZ and EPX-CBZ were analysed in positive ionisation mode and were separated chromatographically using 5 mm, 2 mm´150 mm C18 column at a flow rate of 0.3 mL/min. To improve sensitivity and detectability, SPE was applied as a pre-concentration step for the treated carbamazepine samples to extract and pre-concentrate HDX-CBZ and EPX-CBZ. However, three different solvents, namely, methyl tertiary butyl ether, acetone and methanol, have been optimized to enhance the recovery. The recovery was 85% and 92% for HDX-CBZ and EPX-CBZ, respectively, in the presence of methanol. The limit of quantification (LOQ) was 0.588 and 0.109 µg/L for both by-products, respectively. The concentration of HDX-CBZ and EPX-CBZ was 343 and 144 μg/L, respectively, after 20 min of treatment, then, it was decreased to 17.2 and 9.8 μg/L at 40 min. Finally, both by-products were eliminated after 60 min.

show abstract

Section: Methods Validationcontrasting

confidence: 94%

“…Furthermore, the fate of the by-products was investigated after monitoring the by-products for 60 min of electrochemical degradation of carbamazepine. It was observed that the maximum amount has been formed at 20 The pro le of elucidating the by-products during the electrochemical oxidation process: (top) HDX-CBZ;…”

Section: Discussionmentioning

confidence: 99%

Electrochemical Degradation of Carbamazepine: A Case Study of Quantification of “10, 11 Dihydro-10 Hydroxy Carbamazepine And 10, 11-Epoxycarbamazepine” As The Main By-Products Using LC-TOF/MS.

Mussa

Al-Qaim

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…This indicated that two electrons have taken part in the irreversible oxidation step. 35 Also, the large value of electron transfer rate constant indicates the strong ability of the TiO 2 NPs/CPE to promote electron transfer between PRX and the electrode surface.…”

mentioning

confidence: 99%

A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode

Hassaninejad–Darzi¹,

Shajie²

2016

Journal of the Brazilian Chemical Society

View full text Add to dashboard Cite

In this study, a facile sensor based on TiO 2 nanoparticles modified carbon paste electrode was developed for voltammetric determination of pramipexole in pharmaceutical formulations and biological samples. Surface of the fabricated electrode have been characterized using field emission scanning electron microscopy. Under the optimized experimental conditions, the modified electrode was exhibited excellent electrocatalytic activities and a sensitive oxidation peak at 0.9 V in the phosphate solution of pH 5.0 for electrooxidation of pramipexole. The plot of pH vs. E p generated a slope of 62.5 mV per pH in the pH range of 3.0-13.0 indicating the contribution of an equal number of electrons and protons in the electrode process. A differential pulse voltammetry method was developed in the concentration range of 0.46-100 µmol L −1 with a limit of detection of 0.14 µmol L −1. The proposed method is simple, rapid, and inexpensive and also showed good selectivity and sensitivity toward pramipexole.

show abstract

“…Nanotechnology offers a plethora of materials that already proved enhanced quantitative sensitivity (Hockstein et al, 2004 ; Wei et al, 2009 ; Askim et al, 2013 ), like nanoparticle-based recognition elements or surface-based nanoelectrodes (Alonso-Lomillo et al, 2009 , 2010 ; Esfandyari-Manesh et al, 2012 ; Ginja Teixeira et al, 2013 ). Electronic-polymer-based sensor and nanostructured surface sensors reached clinical trials with nano-electronic “noses” able to “sniff” patterns of volatile organic chemicals that correlates with lung cancer and gastric pathologies (Sheehan and Whitman, 2005b ; Squires et al, 2008 ) and was evaluated in ongoing clinical trials.…”

Section: Perspective On Application Of Nanotechnology In Developing Pmentioning

confidence: 99%

On the Slow Diffusion of Point-of-Care Systems in Therapeutic Drug Monitoring

Sanavio

Krol

2015

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Recent advancements in point-of-care (PoC) technologies show great transformative promises for personalized preventative and predictive medicine. However, fields like therapeutic drug monitoring (TDM), that first allowed for personalized treatment of patients’ disease, still lag behind in the widespread application of PoC devices for monitoring of patients. Surprisingly, very few applications in commonly monitored drugs, such as anti-epileptics, are paving the way for a PoC approach to patient therapy monitoring compared to other fields like intensive care cardiac markers monitoring, glycemic controls in diabetes, or bench-top hematological parameters analysis at the local drug store. Such delay in the development of portable fast clinically effective drug monitoring devices is in our opinion due more to an inertial drag on the pervasiveness of these new devices into the clinical field than a lack of technical capability. At the same time, some very promising technologies failed in the clinical practice for inadequate understanding of the outcome parameters necessary for a relevant technological breakthrough that has superior clinical performance. We hope, by over-viewing both TDM practice and its yet unmet needs and latest advancement in micro- and nanotechnology applications to PoC clinical devices, to help bridging the two communities, the one exploiting analytical technologies and the one mastering the most advanced techniques, into translating existing and forthcoming technologies in effective devices.

show abstract

Electro-oxidation of carbamazepine metabolites: Characterization and influence in the voltammetric determination of the parent drug

Cited by 26 publications

References 46 publications

Electrochemical Degradation of Carbamazepine: A Case Study of Quantification of “10, 11 Dihydro-10 Hydroxy Carbamazepine And 10, 11-Epoxycarbamazepine” As The Main By-Products Using LC-TOF/MS.

Electrochemical Degradation of Carbamazepine: A Case Study of Quantification of “10, 11 Dihydro-10 Hydroxy Carbamazepine And 10, 11-Epoxycarbamazepine” As The Main By-Products Using LC-TOF/MS.

A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode

On the Slow Diffusion of Point-of-Care Systems in Therapeutic Drug Monitoring

Contact Info

Product

Resources

About