Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide

Xie, Chaoming; Luo, Jiaqing; Luo, Yongjie; Zhou, Jie; Guo, Xiaochuan; Lu, Xiong

doi:10.1021/acsami.3c09860

Cited by 17 publications

(7 citation statements)

References 60 publications

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“…(Table S1). For instance, favorable strengthening results have been achieved through in situ mineralization owing to the synergistic reinforcement effect of uniform calcium phosphate and graphene oxide, and the secondary inorganic phases uniformly distributed in the hydrogel. Moreover, salting out brought extraordinary improvements in strength and toughness, with tensile stress up to 23.5 MPa and elongation of 1400% .…”

Section: Discussionmentioning

confidence: 99%

Enzyme-Mineralized PVASA Hydrogels with Combined Toughness and Strength for Bone Tissue Engineering

Zhang,

Wang,

Meng

et al. 2023

ACS Appl. Mater. Interfaces

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Enzymatic mineralization is an advanced mineralization method that is often used to enhance the stiffness and strength of hydrogels, but often accompanied by brittle behavior. Moreover, the hydrogel systems with dense networks currently used for enzymatic mineralization are not ideal materials for bone repair applications. To address these issues, two usual bone repair hydrogels, poly(vinyl alcohol) (PVA) and sodium alginate (SA), were selected to form a double-network structure through repeated freeze−thawing and ionic cross-linking, followed by enzyme mineralization. The results demonstrated that both enzymatic mineralization and double-network structure improved the mechanical and biological properties and even exhibited synergistic effects. The mineralized PVASA hydrogels exhibited superior comprehensive mechanical properties, with a Young's modulus of 1.03 MPa, a storage modulus of 103 kPa, and an equilibrium swelling ratio of 132%. In particular, the PVASA hydrogel did not suffer toughness loss after mineralization, with a high toughness value of 1.86 MJ/m 3 . The prepared hydrogels also exhibited superior biocompatibility with a cell spreading area about 13 times that of mineralized PVA. It also effectively promoted cellular osteogenic differentiation in vitro and further promoted the formation of new bone in the femur defect region in vivo. Overall, the enzyme-mineralized PVASA hydrogel demonstrated combined strength and toughness and great potential for bone tissue engineering applications.

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Section: Discussionmentioning

confidence: 99%

Enzyme-Mineralized PVASA Hydrogels with Combined Toughness and Strength for Bone Tissue Engineering

Zhang,

Wang,

Meng

et al. 2023

ACS Appl. Mater. Interfaces

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“…Among the different types of graphene, graphene oxide (GO) is one of the most studied materials for photothermal application, due to its particular physico-chemical properties, such as a large specific surface area, abundant oxygen functional groups (the ability to interact with various biologically active agents), good biocompatibility, thermal stability, etc. [ 32 , 33 , 34 ]. Thus, GO can absorb NIR radiation and can also be applied for quickly releasing therapeutic agents from the surface through NIR.…”

Section: Introductionmentioning

confidence: 99%

Novel Photothermal Graphene-Based Hydrogels in Biomedical Applications

Croitoru,

Ficai,

Ficai

2024

Polymers

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In the last decade, photothermal therapy (PTT) has attracted tremendous attention because it is non-invasive, shows high efficiency and antibacterial activity, and minimizes drug side effects. Previous studies demonstrated that PTT can effectively inhibit the growth of bacteria and promotes cell proliferation, accelerating wound healing and tissue regeneration. Among different NIR-responsive biomaterials, graphene-based hydrogels with photothermal properties are considered as the best candidates for biomedical applications, due to their excellent properties. This review summarizes the current advances in the development of innovative graphene-based hydrogels for PTT-based biomedical applications. Also, the information about photothermal properties and the potential applications of graphene-based hydrogels in biomedical therapies are provided. These findings provide a great potential for supporting their applications in photothermal biomedicine.

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“…However, the lack of injectability for this hydrogel restricted its adaptability to diverse wound geometries, illustrating the ongoing balance between design innovation and practical application in wound care research. 35 Articular cartilage has been regarded as one of the most effective lubricating system due to the synergistic hydration lubrication mechanism of hyaluronic acid, aggrecan, lubricin, and phosphatidylcholine lipid, and the tenacious hydration layer surrounding the zwitterionic charges of the biomacromolecules can also achieve excellent bacterial resistance. 36−38 Specifically, hydration lubrication is a mechanism primarily associated with biotribology, which investigates friction, wear, and lubrication in various types of biological systems.…”

Section: Introductionmentioning

confidence: 99%

Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

Guo,

Wang,

Wang

et al. 2024

Chem. Mater.

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Wound healing is a prolonged physiological process involving a series of complicated biological responses influenced by various factors, such as bacterial infection and oxidative damage. Existing treatments, while effective, have certain limitations in terms of biocompatibility, responsiveness to the wound environment, and efficacy in promoting tissue regeneration. To address these shortcomings, bioinspired by hydration lubrication mechanism of articular cartilage, we successfully designed and developed an injectable in situ photo-cross-linkable hydrogel, which was synthesized via modifying aminated hyaluronic acid with a polymer obtained by free radical polymerization of o-nitrobenzyl alcohol derivative (NB) and 2-methoxyethyl phosphocholine (MPC). The hydrophilic hydration layer formed around the zwitterionic charges in MPC endowed the hydrogel with enhanced lubrication and antimicrobial effects, whereas the hydroxymethyl group in NB enabled the hydrogel to process ultraviolet light-induced cross-linking property. The hydrogel, doped with polydopamine nanoparticles, facilitated multifaceted wound healing by the mechanism of photothermally responsive antibacterial, anti-inflammation, and angiogenesis. Specifically, upon injection of the hydrogel precursor solution into the wound site and exposure to ultraviolet light, the hydrogel cross-linked and adhered closely to the skin tissues, achieving hemostasis and exudate absorption. Additionally, the hydrogel showed excellent reactive oxygen species scavenging property, reducing cellular oxidative stress and meanwhile promoting the bactericidal effect with near-infrared light irradiation. Furthermore, the hydrogel, with its networked porous structure, was conducive to cell adhesion and proliferation, remarkably enhancing the cellular activity and tissue regeneration. The wound-healing performances of the hydrogel were investigated in both in vitro and in vivo experiments, showcasing its potential for wound treatment applications, offering a promising improvement over the current methods by providing a photothermal responsive, biocompatible, and effective healing process.

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Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide

Cited by 17 publications

References 60 publications

Enzyme-Mineralized PVASA Hydrogels with Combined Toughness and Strength for Bone Tissue Engineering

Enzyme-Mineralized PVASA Hydrogels with Combined Toughness and Strength for Bone Tissue Engineering

Novel Photothermal Graphene-Based Hydrogels in Biomedical Applications

Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

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