Electroactive metal–organic framework composites: Design and biosensing application

Liao, Xin; Fu, Haomin; Yan, Tingting; Lei, Jianping

doi:10.1016/j.bios.2019.111743

Cited by 93 publications

(34 citation statements)

References 95 publications

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“…Metal-organic frameworks (MOFs) are constructed by unification of metal ions with organic ligands having highly ordered structures. Due to specific surface area, low density, and porosity structure, MOFs have started to attract great attention [23]. They are used as a sensor amplification especially in drug delivery, electrochemistry applications, and energy storage [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite

Yola

2021

Microchim Acta

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A sandwich-type sensitive voltammetric immunosensor for breast cancer biomarker human epidermal growth factor receptor 2 (HER2) detection was prepared. The electrochemical immunosensor was developed based on gold nanoparticles decorated copper-organic framework (AuNPs/Cu-MOF) and quaternary chalcogenide with platinum-doped graphitic carbon nitride (g-C 3 N 4 ). Cu 2 ZnSnS 4 nanoparticle (CZTS NP) quaternary chalcogenide with platinum (Pt)-doped g-C 3 N 4 composite (Pt/g-C 3 N 4 ) was tagged as CZTS NPs/Pt/g-C 3 N 4 . AuNPs/Cu-MOF composite was successfully synthesized by amidation reaction between AuNPs functionalized with amino group and Cu-MOFs containing carboxylic acid. After the conjugations of primer HER2 antibody and antigen HER2 protein to AuNPs/Cu-MOF as sensor platform, CZTS NPs/Pt/g-C 3 N 4 composite was prepared by one-pot hydrothermal method. After immune reaction of 30 min, the prepared HER2 immunosensor was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD) method, x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The developed immunosensor showed high sensitivity with a detection limit of 3.00 fg mL −1 . Additional properties of the voltammetric immunosensor are high selectivity, stability, reproducibility, and reusability.

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Section: Introductionmentioning

confidence: 99%

Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite

Yola

2021

Microchim Acta

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“…Metal-organic frameworks (MOFs) are a novel class of crystallized porous materials that are self-assembled by metal clusters as connecting points and organic ligands as bridging molecules to form a two- or three-dimensional framework through coordination bonds [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. MOFs have attracted great interests in recent years by having remarkable features such as adjustable structure, high porosity, large specific surface area, good modifiability and excellent stability and have been used widely in many areas, for example, adsorption [ 8 , 9 , 10 , 11 , 12 , 13 ], catalysis [ 14 , 15 , 16 , 17 , 18 ], sensing [ 19 , 20 , 21 , 22 , 23 ], drug delivery [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ] and gas storage and separation [ 31 , 32 , 33 ], etc. Besides the intrinsic properties of MOFs, their morphology and size also play crucial roles for their practical applications.…”

Section: Introductionmentioning

confidence: 99%

Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8: Effect of Molecular Hydrophobicity, Charge Number and Charge Location

et al. 2021

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Three amphiphilic peptides with varied molecular hydrophobicity, charge number and charge location have been designed as regulators to modulate the crystal growth of zeolitic imidazolate framework-8 (ZIF-8). All three peptides can interact with ZIF-8 to inhibit {100} facet growth and produce truncated cubic crystals. The peptide’s molecular hydrophobicity plays a dominant role in defining the final morphology and size of the ZIF-8 crystals. The peptides with less charge and higher hydrophobicity can promote nuclei formation and crystal growth to give smaller ZIF-8 crystals. However, the charge located in the center of the molecular hydrophobic region has little effect on the crystal nucleation and growth due to the shielding of its charge by molecular aggregation. The study provides insights into the effect of molecular charge and hydrophobicity on ZIF-8 crystal growth and is helpful for guiding the molecular design for regulating the synthesis of metal-organic framework materials.

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“…However, the above techniques showed many disadvantages such as long testing times, expensive equipment, and complex measurement processes [3,5]. Therefore, development of new techniques, which possess the advantages of high sensitivity, quick detection, and ease of use, is needed for the onsite, real-time, and continuous monitoring of environmental pollutants [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Metal-Organic Framework MIL-53(Fe): Synthesis, Electrochemical Characterization, and Application in Development of a Novel and Sensitive Electrochemical Sensor for Detection of Cadmium Ions in Aqueous Solutions

Tran

Dang

Tran

et al. 2020

Advances in Polymer Technology

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A metal-organic framework MIL-53(Fe) was successfully synthesized by a simple hydrothermal method. A synthesized MIL-53(Fe) sample was characterized, and results indicated that the formed MIL-53(Fe) was a single phase with small particle size of 0.8 μm and homogeneous particle size distribution was obtained. The synthesized MIL-53(Fe) has been used to modify a glassy carbon electrode (GCE) by a drop-casting technique. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements of the MIL-53(Fe)-modified GCE showed that the MIL-53(Fe) was successfully immobilized onto the GCE electrode surface and the electrochemical behavior of the GCE/MIL-53(Fe) electrode was stable. In addition, several electrochemical parameters of MIL-53(Fe)-modified GCE (GCE/MIL-53(Fe)) including the heterogeneous standard rate constant ( k 0 ) and the electrochemically effective surface area ( A ) were calculated. Obtained results demonstrated that the synthesized MIL-53(Fe) with the small particle size, highly homogeneous particle size, and high electrochemically effective surface area was able to significantly enhance the electrochemical response signal of the working electrode. Therefore, the GCE/MIL-53(Fe) electrode has been used as a highly sensitive electrochemical sensor for cadmium ion (Cd(II)) monitoring in aqueous solution using differential pulse voltammetry (DPV) technique. The response signal of the electrochemical sensor increased linearly in the Cd(II) ion concentration range from 150 nM to 450 nM with the limit of detection (LOD) of 16 nM.

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Electroactive metal–organic framework composites: Design and biosensing application

Cited by 93 publications

References 95 publications

Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite

Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite

Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8: Effect of Molecular Hydrophobicity, Charge Number and Charge Location

Metal-Organic Framework MIL-53(Fe): Synthesis, Electrochemical Characterization, and Application in Development of a Novel and Sensitive Electrochemical Sensor for Detection of Cadmium Ions in Aqueous Solutions

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