Electroacupuncture alleviates early brain injury via modulating microglia polarization and suppressing neuroinflammation in a rat model of subarachnoid hemorrhage

Wang, Yingwen; Yang, Xiaomin; Cao, Yunchuan; Li, Xiaoguo; Xu, Rui; Jin, Yan; Guo, Zongduo; Sun, Shanquan; Sun, Xiaochuan; Wu, Yue

doi:10.1016/j.heliyon.2023.e14475

Cited by 4 publications

(1 citation statement)

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“…Glycoprotein non-metastatic melanoma protein B (GPNMB) is widely expressed in neurons, microglia, and astrocytes, which significantly increases after SAH by activating AMPK/NF-κB signaling pathway, inhibiting p-NF-κB, IL-1β, IL-6, and TNFα, then reduce blood-brain barrier damage and neuroinflammation, alleviate brain edema, and improve neurological function in SAH mice [ 86 ]. Animal experiments have shown that traditional Chinese medicine electroacupuncture therapy can exert anti-inflammatory effects and reduce neuronal apoptosis by regulating the polarization of microglia, alleviating early brain injury after SAH [ 87 ]. Low-dose lipopolysaccharide (LPS) activates the IL-10/IL-10R1 signaling pathway through the deubiquitination of FOXO1 mediated by USP19, regulates microglial polarization, reduces brain edema, blood-brain barrier disruption, neuroinflammation, etc., and has a protective effect on EBI [ 88 ].…”

Section: Potential Mechanisms Of Early Brain Injurymentioning

confidence: 99%

Ferroptosis in early brain injury after subarachnoid hemorrhage: review of literature

Kang,

Tian,

Zhang

et al. 2024

Chin Neurosurg Jl

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Spontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.

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Section: Potential Mechanisms Of Early Brain Injurymentioning

confidence: 99%