Electroacupuncture Alleviates Pain‐Related Emotion by Upregulating the Expression of NPS and Its Receptor NPSR in the Anterior Cingulate Cortex and Hypothalamus

Xu, Zitong; Fang, Jiaqi; Xiang, Xuaner; Sun, Haiju; Wang, Sisi; Fang, Jianqiao; Du, Junying

doi:10.1155/2020/8630368

Cited by 9 publications

(8 citation statements)

References 74 publications

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“…Both animal and human studies have shown that EA can significantly improve chronic inflammatory pain and pain-induced disorders ( Lin et al, 2020 ). Our previous studies have demonstrated that EA relieved chronic inflammatory pain and pain-related anxiety by downregulating PKMzeta expression and upregulating the neuropeptide S (NPS)/NPSR system in the anterior cingulate cortex (ACC) ( Du et al, 2017 ; Du et al, 2020 ; Xu et al, 2020 ). However, the underlying mechanisms by which EA ameliorates chronic inflammatory pain-related anxiety has not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Ameliorates Chronic Inflammatory Pain-Related Anxiety by Activating PV Interneurons in the Anterior Cingulate Cortex

et al. 2021

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Chronic inflammatory pain is a common clinical disease that tends to be associated with negative emotions such as anxiety and depression. The anterior cingulate cortex (ACC) is involved in pain and pain-related anxiety, and γ-aminobutyric acid (GABA)-ergic interneurons play an important role in chronic pain and anxiety. Electroacupuncture (EA) has good analgesic and antianxiety effect, but the underlying mechanisms have not yet been fully elucidated. In this study, we established a chronic inflammatory pain model and observed that this model induced anxiety-like behaviors and decreased the numbers of parvalbumin (PV) and somatostatin (SOM) positive cells. Activation of PV but not SOM interneurons by chemogenetic techniques alleviated anxiety-like behaviors and pain sensation. EA treatment improved pain sensation, anxiety-like behaviors and increased the number of PV- positive cells in the ACC, but did not affect on the number of SOM-positive cells in the ACC. Moreover, specific inhibition of PV interneurons by chemogenetic methods reversed the analgesic and antianxiety effects of EA. These results suggest that EA ameliorates chronic inflammatory pain and pain-related anxiety by upregulating PV but not SOM interneurons in the ACC.

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Section: Introductionmentioning

confidence: 99%

Electroacupuncture Ameliorates Chronic Inflammatory Pain-Related Anxiety by Activating PV Interneurons in the Anterior Cingulate Cortex

et al. 2021

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“…The limbic system includes a wide range of interconnected brain regions that process and regulate cognitive function, sensory perception, memory, emotions, and affective motivation ( 68 ). Various limbic regions participate in pain processing circuits, including the hypothalamus ( 68 – 70 ), amygdala, and ACC ( 68 , 71 – 73 ).…”

Section: Preclinical Modelsmentioning

confidence: 99%

Translational aspects of deep brain stimulation for chronic pain

et al. 2023

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The use of deep brain stimulation (DBS) for the treatment of chronic pain was one of the first applications of this technique in functional neurosurgery. Established brain targets in the clinic include the periaqueductal (PAG)/periventricular gray matter (PVG) and sensory thalamic nuclei. More recently, the anterior cingulum (ACC) and the ventral striatum/anterior limb of the internal capsule (VS/ALIC) have been investigated for the treatment of emotional components of pain. In the clinic, most studies showed a response in 20%–70% of patients. In various applications of DBS, animal models either provided the rationale for the development of clinical trials or were utilized as a tool to study potential mechanisms of stimulation responses. Despite the complex nature of pain and the fact that animal models cannot reliably reflect the subjective nature of this condition, multiple preparations have emerged over the years. Overall, DBS was shown to produce an antinociceptive effect in rodents when delivered to targets known to induce analgesic effects in humans, suggesting a good predictive validity. Compared to the relatively high number of clinical trials in the field, however, the number of animal studies has been somewhat limited. Additional investigation using modern neuroscience techniques could unravel the mechanisms and neurocircuitry involved in the analgesic effects of DBS and help to optimize this therapy.

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“…Encephalin and endorphin relieve pain-related emotions by upregulating the expression of neuropeptide S and its receptor in the anterior cingulate cortex and hypothalamus. 12 While the mechanism of acupuncture underlying PONV prevention has not been well elucidated, it may reduce PONV by releasing beta-endorphin or altering the transmission of serotonin. 13 Clinical trials and existing reviews indicate that AAA helps reduce the consumption of anaesthetic and analgesic agents, prevent PONV and relieve anxiety during surgery.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Acupuncture-assisted anaesthesia for catheter ablation of atrial fibrillation to reduce the consumption of morphine hydrochloride and postoperative nausea and vomiting (PONV): study protocol for a randomised controlled trial

et al. 2022

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BackgroundPatients often experience postoperative nausea and vomiting (PONV) after catheter ablation of atrial fibrillation (AF) because of the use of opioids for anaesthesia and analgesia during the procedure. Some clinical trials have demonstrated that acupuncture-assisted anaesthesia (AAA) reduces opioid consumption and prevents PONV. Although several studies have been conducted on AAA, its safety and efficacy in AF catheter ablation remain unclear due to small sample sizes and a paucity of methodologically rigorous designs. Therefore, this trial was designed to evaluate the safety and efficacy of AAA in reducing PONV and morphine hydrochloride consumption during catheter ablation.MethodsThis single-centre, patient-blinded, randomised, non-penetrating sham-controlled trial will be conducted in China. A total of 100 patients will be randomly assigned to the AAA and conventional anaesthesia (CA) groups in a ratio of 1:1. The patients will receive AAA or CA plus sham acupuncture during catheter ablation and will be followed up for 30 days. The primary outcomes include the total amount of morphine hydrochloride consumed during catheter ablation and PONV within the first 24 hours after the procedure. The secondary outcomes include pain, nausea and vomiting, anxiety, patient’s ability to cope during catheter ablation, AF recurrence and quality of life, as assessed using the numeric rating scale. Adverse events will be recorded and their influence will be analysed at the end of the trial.DiscussionThis study will help in evaluating the safety and efficacy of AAA applied for AF catheter ablation in reducing opioid doses during the procedure and the occurrence of PONV.Ethics and disseminationThe study has been approved by the Medical Ethics Committee of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine. The results of the study will be published in peer-reviewed journals and presented at conferences if possible.Trial registration numberChiCTR 2100042646; Chinese Clinical Trial Registry.

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Electroacupuncture Alleviates Pain‐Related Emotion by Upregulating the Expression of NPS and Its Receptor NPSR in the Anterior Cingulate Cortex and Hypothalamus

Cited by 9 publications

References 74 publications

Electroacupuncture Ameliorates Chronic Inflammatory Pain-Related Anxiety by Activating PV Interneurons in the Anterior Cingulate Cortex

Electroacupuncture Ameliorates Chronic Inflammatory Pain-Related Anxiety by Activating PV Interneurons in the Anterior Cingulate Cortex

Translational aspects of deep brain stimulation for chronic pain

Acupuncture-assisted anaesthesia for catheter ablation of atrial fibrillation to reduce the consumption of morphine hydrochloride and postoperative nausea and vomiting (PONV): study protocol for a randomised controlled trial

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