Electroacupuncture Ameliorates Cognitive Impairment by Regulating γ-Amino Butyric Acidergic Interneurons in the Hippocampus of 5 Familial Alzheimer’s Disease Mice

Li, Hongzhu; Lai, Lanfeng; Li, Xin; Wang, Runyi; Fang, Xiaoling; Xu, Nenggui; Zhao, Jiaying

doi:10.1016/j.neurom.2022.11.014

“…Abnormal γ and θ rhythms in brain oscillatory activities have been demonstrated among patients with AD, while interfering with GABAergic interneurons could restore γ oscillation ( Verret et al, 2012 ). In five familial Alzheimer’s disease (5 × FAD) mutation mice, EA at GV20 and GV14 ameliorates recognition learning and memory function deficits, restores glutamate decarboxylase 65 (GAD65) and somatostatin (SST) in the hippocampus, attenuates the loss of somatostatin-positive interneurons in the dorsal hippocampus, and reverses the decreased θ and γ brain oscillations ( Li et al, 2023 ; Table 2 ; Figure 4 ).…”

Section: Neural Circuit Mechanism Of Acupuncture On Cognitive Impairm...mentioning

confidence: 99%

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Li,

Deng,

Jiang

et al. 2024

Front. Neurosci.

1

0

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Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (GABAergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. These findings can provide targets for clinical treatment and perspectives for further studies.

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“…Electroacupuncture (EA) stimulation is employed as an effective and safe therapy to treat multiple diseases including inflammation (Liu et al, 2021; Liu et al, 2020), Parkinson’s disease (Tamtaji et al, 2019), insomnia (Ruan et al, 2009; Yin et al, 2017; Yin et al, 2020), anxiety (Shen et al, 2020) and depression (Jiang et al, 2021; Xu et al, 2020b; Yao et al, 2021). The EA at selective acupoints Dazhui (DU14) and Baihui (DU20) was shown to restore inhibitory/excitatory balance and improve cognition in mouse models of Alzheimer’s disease (Li et al, 2023). Several studies indicated that EA affects astrocytes by modulating expression of glial fibrillary acid protein (GFAP) (Yang et al, 2021) and production of fibroblast growth factor 2 (FGF2), the latter being beneficial for alleviating depressive-like behaviour (Yao et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture prevents astrocyte atrophy to alleviate depression

Lin

¹

,

Zhou

²

,

Chen³

et al. 2023

Preprint

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Astrocyte atrophy is the main histopathological hallmark of the major depressive disorder (MDD) in humans and in animal models of depression. Here we show that electroacupuncture prevents astrocyte atrophy in the prefrontal cortex and alleviates depressive-like behaviour in mice subjected to the chronic unpredictable mild stress (CUMS). Treatment of mice with CUMS induced depressive-like phenotypes as confirmed by sucrose preference test, tail suspension test, and forced swim test. These behavioural changes were paralleled with morphological atrophy of astrocytes in the prefrontal cortex, revealed by analysis of 3D reconstructions of confocal Z-stack images of mCherry expressing astrocytes. This morphological atrophy was accompanied with a decrease in expression of cytoskeletal linker Ezrin, associated with formation of astrocytic leaflets, which form astroglial synaptic cradle. Electroacupuncture at the acupoint ST36 as well as treatment with anti-depressant fluoxetine prevented depressive-like behaviours, astrocytic atrophy and down-regulation of astrocytic ezrin. In conclusion, our data further strengthen the notion of a primary role of astrocytic atrophy in depression and reveal astrocytes as cellular target for electroacupuncture in treatment of depressive disorders.

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“…Electroacupuncture (EA) stimulation is employed as an effective and safe therapy to treat multiple diseases including in ammation 21,22 , Parkinson's disease 23 , insomnia 24,25,26 , anxiety 27 and depression 28,29,30 . The EA at selective acupoints Dazhui (DU14) and Baihui (DU20) was shown to restore inhibitory/excitatory balance and improve cognition in mouse models of Alzheimer's disease 31 . Several studies indicated that EA affects astrocytes by modulating expression of glial brillary acid protein (GFAP) 32 and production of broblast growth factor 2 (FGF2), the latter being bene cial for alleviating depressive-like behaviour 30 .…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture prevents astrocyte atrophy to alleviate depression

Lin

¹

,

Zhou

²

,

Chen³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Astrocyte atrophy is the main histopathological hallmark of the major depressive disorder (MDD) in humans and in animal models of depression. Here we show that electroacupuncture prevents astrocyte atrophy in the prefrontal cortex and alleviates depressive-like behaviour in mice subjected to the chronic unpredictable mild stress (CUMS). Treatment of mice with CUMS induced depressive-like phenotypes as confirmed by sucrose preference test, tail suspension test, and forced swim test. These behavioural changes were paralleled with morphological atrophy of astrocytes in the prefrontal cortex, revealed by analysis of 3D reconstructions of confocal Z-stack images of mCherry expressing astrocytes. This morphological atrophy was accompanied with a decrease in expression of cytoskeletal linker Ezrin, associated with formation of astrocytic leaflets, which form astroglial synaptic cradle. Electroacupuncture at the acupoint ST36 as well as treatment with anti-depressant fluoxetine prevented depressive-like behaviours, astrocytic atrophy and down-regulation of astrocytic ezrin. In conclusion, our data further strengthen the notion of a primary role of astrocytic atrophy in depression and reveal astrocytes as cellular target for electroacupuncture in treatment of depressive disorders.

show abstract

Electroacupuncture Ameliorates Cognitive Impairment by Regulating γ-Amino Butyric Acidergic Interneurons in the Hippocampus of 5 Familial Alzheimer’s Disease Mice

Cited by 6 publications

References 61 publications

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Electroacupuncture prevents astrocyte atrophy to alleviate depression

Electroacupuncture prevents astrocyte atrophy to alleviate depression

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