Electroacupuncture and acupuncture in the treatment of anxiety - A double blinded randomized parallel clinical trial

Amorim, Diogo; Brito, Irma da Silva; Caseiro, Armando; Figueiredo, João Paulo; Pinto, André Luíz de Carvalho Braule; Macedo, Inês; Machado, Jorge

doi:10.1016/j.ctcp.2022.101541

Cited by 25 publications

(13 citation statements)

References 24 publications

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“…[52,53] It regulates the ratio of sympathetic and parasympathetic activity, thereby reducing anxiety and depressive symptoms and improving mental health. [54] This provides a possible mechanism for ACU to treat IBS.…”

Section: Discussionmentioning

confidence: 99%

Different acupuncture and moxibustion therapies in the treatment of IBS-D with anxiety and depression: A network meta-analysis

Hou,

Chang,

Liu

et al. 2024

Medicine

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Background: Currently, a variety of Western medical interventions are available for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) with comorbid anxiety and depression. However, the attendant negative effects also emerge, putting pressure on healthcare resources and socio-economic structures. In recent years, the benefits of acupuncture (ACU) and moxibustion in the treatment of IBS-D with anxiety and depression have gradually emerged. However, there are many types of ACU-moxibustion-related treatments, and the aim of this study is to examine the effectiveness of different ACU-moxibustion therapies in the treatment of anxiety and depression in IBS-D patients. Methods: Searched and identified randomized controlled trials (RCTS) of ACU for the treatment of anxiety and depression in patients with irritable bowel syndrome (IBS). The search spanned from the establishment of the database until September 1, 2023. Revman 5.4 and Stata 15.0 software were used for network meta-analysis (NMA), and the included interventions were ranked by the area under the cumulative ranking curve. Results: A total of 26 articles involving 8 interventions were included. In terms of improving HAMA score, MOX was superior to EA, combined therapies, CH, WM and placebo; In terms of improving HAMD score, MOX was superior to ACU, EA, combined therapies, WM and placebo; In terms of improving the SAS score, The combined therapies were superior to EA, CH and WM; In terms of improving SDS scores, The combined therapies were superior to EA, CH and WM; In terms of improving IBS-SSS score, The combined therapies were superior to WM; In terms of reducing recurrence rates, CH was superior to combined therapies; In terms of improving total effective rates, MOX was superior to EA, CH, WM and placebo; MOX, combined therapies, ACU and EA ranked higher in SUCRA of different outcome indicators. Conclusion: MOX, combined therapies, ACU and EA have certain curative effect on anxiety and depression in patients with IBS-D, and their safety is high. ACU and MOX combined with other therapies also have significant advantages in the treatment effect.

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Section: Discussionmentioning

confidence: 99%

Different acupuncture and moxibustion therapies in the treatment of IBS-D with anxiety and depression: A network meta-analysis

Hou,

Chang,

Liu

et al. 2024

Medicine

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“…Acupuncture is now used worldwide for treatment of various medical conditions (Jang et al, 2020; Liu et al, 2021; Tang et al, 2016; Xu et al, 2020a). Acupuncture is employed for therapies of neuropsychiatric diseases, including depression (Jung et al, 2021; MacPherson et al, 2013) and anxiety (Amorim et al, 2022). In particular, 6 weeks of acupuncture at acupoints Baihui (GV20) and Zusanli (ST36), or Taichong (LR3), Sanyinjiao (SP6), Neiguan (PC6), and Shenmen (HT7), was as effective as oral fluoxetine in treating depression, although acupuncture showed better response and improvement rates (Sun et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture prevents astrocyte atrophy to alleviate depression

Lin

Zhou

Chen³

et al. 2023

Preprint

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Astrocyte atrophy is the main histopathological hallmark of the major depressive disorder (MDD) in humans and in animal models of depression. Here we show that electroacupuncture prevents astrocyte atrophy in the prefrontal cortex and alleviates depressive-like behaviour in mice subjected to the chronic unpredictable mild stress (CUMS). Treatment of mice with CUMS induced depressive-like phenotypes as confirmed by sucrose preference test, tail suspension test, and forced swim test. These behavioural changes were paralleled with morphological atrophy of astrocytes in the prefrontal cortex, revealed by analysis of 3D reconstructions of confocal Z-stack images of mCherry expressing astrocytes. This morphological atrophy was accompanied with a decrease in expression of cytoskeletal linker Ezrin, associated with formation of astrocytic leaflets, which form astroglial synaptic cradle. Electroacupuncture at the acupoint ST36 as well as treatment with anti-depressant fluoxetine prevented depressive-like behaviours, astrocytic atrophy and down-regulation of astrocytic ezrin. In conclusion, our data further strengthen the notion of a primary role of astrocytic atrophy in depression and reveal astrocytes as cellular target for electroacupuncture in treatment of depressive disorders.

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“…51 Acupuncture at Sanyinjiao and Hegu has been clinically proven to benefit not only sleep, but mood disorders as well. 52 In addition, sleep disorders and mood disorders may degrade the quality of life of Parkinson's disease patients. 53 The Parkinson's Disease Questionnaire 39 has been widely used as a Parkinson's disease-specific quality of life assessment tool, with lower scores reflecting better quality of life.…”

Section: Discussionmentioning

confidence: 99%

Effects of acupuncture on sleep quality in patients with Parkinson's disease: A systematic review and meta-analysis

Lin,

Kong,

Chen

et al. 2023

Clin Rehabil

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Objective To systematically evaluate the evidence relating to acupuncture on the sleep quality of patients with Parkinson's disease. Data sources Six English-language (PubMed, Cochrane Library, EBSCOhost, Embase, OVID MEDLINE, and Web of Science) and four Chinese-language (China National Knowledge Infrastructure, SinoMed, China Scientific Journals Database, and Wanfang) databases were searched for pertinent studies published from database inception to 11 October 2023. Methods Two researchers independently screened eligible studies and extracted relevant data using custom data extraction tables. Methodological quality assessment of the included studies was performed using Cochrane Handbook 5.1.0. Meta-analysis was performed using Cochrane Review Manager version 5.4. Results Twenty-four studies (1701 participants) met inclusion criteria. The meta-analysis showed that acupuncture improved the Parkinson's Disease Sleep Scale, Pittsburgh Sleep Quality Index, Hamilton Anxiety Scale, Hamilton Depression Scale, Self-Rating Depression Scale, and Parkinson's Disease Questionnaire 39 scores compared with controls (all P < 0.05). Conclusion This review showed that acupuncture improved sleep quality, anxiety and depressive symptoms, and quality of life of patients with Parkinson's disease relative to controls.

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Electroacupuncture and acupuncture in the treatment of anxiety - A double blinded randomized parallel clinical trial

Cited by 25 publications

References 24 publications

Different acupuncture and moxibustion therapies in the treatment of IBS-D with anxiety and depression: A network meta-analysis

Different acupuncture and moxibustion therapies in the treatment of IBS-D with anxiety and depression: A network meta-analysis

Electroacupuncture prevents astrocyte atrophy to alleviate depression

Effects of acupuncture on sleep quality in patients with Parkinson's disease: A systematic review and meta-analysis

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