Electroacupuncture at ST 36 ameliorates cognitive impairment and beta-amyloid pathology by inhibiting NLRP3 inflammasome activation in an Alzheimer’s disease animal model

Ni, Hong; Ren, Jiaoqi; Li, Xing; Wu, Yue; Liu, Dezhi; Wang, Jie

doi:10.1016/j.heliyon.2023.e16755

Cited by 9 publications

(2 citation statements)

References 61 publications

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“…EA stimulation of ST36 effectively improved motor, spatial learning and memory abilities in mice by reducing microglial activation, decreasing beta-amyloid (Aβ) peptide deposition, and inhibiting the NLRP3 inflammatory response (IL-1β and IL-18 expression) in the hippocampus, thereby attenuating neuroinflammation ( Ni et al, 2023 ). Interestingly, the therapeutic effects of EA were similarly observed in POCD.…”

Section: Biological Mechanism Of Electroacupuncture For Postoperative...mentioning

confidence: 99%

“…The expression of IL-1β in the brain initiates subsequent inflammatory events, and IL-1β plays a critical role in the development of postoperative infection, preoperative cognitive impairment, and postoperative pain processes (Zhao et al, 2021). EA stimulation of ST36 effectively improved motor, spatial learning and memory abilities in mice by reducing microglial activation, decreasing beta-amyloid (Aβ) peptide deposition, and inhibiting the NLRP3 inflammatory response (IL-1β and IL-18 expression) in the hippocampus, thereby attenuating neuroinflammation (Ni et al, 2023). Interestingly, the therapeutic effects of EA were similarly observed in POCD.…”

Section: Neuroinflammationmentioning

confidence: 99%

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Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies

Zhao,

Zou

2024

Front. Aging Neurosci.

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With the aging of the population, the health of the elderly has become increasingly important. Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients following general anesthesia or surgery. It is characterized by cognitive decline that may persist for weeks, months, or even longer. Electroacupuncture (EA), a novel therapy that combines physical nerve stimulation with acupuncture treatment from traditional Chinese medicine, holds potential as a therapeutic intervention for preventing and treating POCD, particularly in elderly patients. Although the beneficial effects of EA on POCD have been explored in preclinical and clinical studies, the reliability of EA is limited by methodological shortcomings, and the underlying mechanisms remain largely unexplored. Therefore, we have synthesized existing evidence and proposed potential biological mechanisms underlying the effects of EA on neuroinflammation, oxidative stress, autophagy, the microbiota-gut-brain axis, and epigenetic modification. This review summarizes recent advances in EA and POCD, provides a theoretical foundation, explores potential molecular mechanisms for the prevention and treatment of POCD, and offers a basis for conducting relevant clinical trials.

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Section: Biological Mechanism Of Electroacupuncture For Postoperative...mentioning

confidence: 99%

Section: Neuroinflammationmentioning

confidence: 99%

Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies

Zhao,

Zou

2024

Front. Aging Neurosci.

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Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice

Yang,

Zhou,

Huang

et al. 2024

Advanced Science

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Lack of liver regenerative capacity is the primary cause of hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance liver regeneration is pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on liver regeneration following partial hepatectomy, thereby substantiating the pivotal role played by the vagus nerve in the process of liver regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique for stimulating the vagus nerve. However, EA on hepatic regeneration remains uncertain. In this study, a 70% partial hepatectomy (PH) mouse model is utilized to investigate the effects of EA on acute liver regeneration and elucidate its underlying molecular mechanisms. It is observed that EA at ST36 acutely activated cholinergic neurons in the dorsal motor nucleus of the vagus nerve (DMV), resulting in increased release of acetylcholine from hepatic vagal nerve endings and subsequent activation of IL‐6 signaling in liver macrophages. Ultimately, these events promoted hepatocyte proliferation and facilitated liver regeneration. These findings provide insights into the fundamental brain‐liver axis mechanism through which EA promotes liver regeneration, offering a novel therapeutic approach for post‐hepatectomy liver regeneration disorders.

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What is the Vagal–Adrenal Axis?

Trevizan‐Baú,

McAllen

2024

J of Comparative Neurology

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Some recent publications have used the term “vagal–adrenal axis” to account for mechanisms involved in the regulation of inflammation by electroacupuncture. This concept proposes that efferent parasympathetic nerve fibers in the vagus directly innervate the adrenal glands to influence catecholamine secretion. Here, we discuss evidence for anatomical and functional links between the vagi and adrenal glands that may be relevant in the context of inflammation and its neural control by factors, including acupuncture. First, we find that evidence for any direct vagal parasympathetic efferent innervation of the adrenal glands is weak and likely artifactual. Second, we find good evidence that vagal afferent fibers directly innervate the adrenal gland, although their function is uncertain. Third, we highlight a wealth of evidence for indirect pathways, whereby vagal afferent signals act via the central nervous system to modify adrenal‐dependent anti‐inflammatory responses. Vagal afferents, not efferents, are thus the likely key to these phenomena.

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Electroacupuncture at ST 36 ameliorates cognitive impairment and beta-amyloid pathology by inhibiting NLRP3 inflammasome activation in an Alzheimer’s disease animal model

Cited by 9 publications

References 61 publications

Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies

Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies

Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice

What is the Vagal–Adrenal Axis?

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