Electroacupuncture for Reproductive Hormone Levels in Patients with Diminished Ovarian Reserve: A Prospective Observational Study

Wang, Yang; Li, Yanhong; Chen, Ruixue; Cui, Xiaoming; Yu, Jinming; Liu, Zhishun

doi:10.1136/acupmed-2015-011014

Cited by 34 publications

(23 citation statements)

References 24 publications

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“…For example, acupuncture can reduce the burden of menopause-related symptoms, 37 increase levels of oestradiol, 38 treat premature ovarian failure 39 and improve diminished ovarian reserve. 40 These effects may be related to upregulation of gene and protein expression of components of the PI3K/Akt/ mTOR signalling pathway. 41 Our study suggests that acupuncture can improve ovarian hormone and oestrous cycle disorders, which is encouraging with respect to the potential role of acupuncture in the treatment of ovarian failure.…”

Section: Ea Simultaneously Improved Ovarian Cycle and Glucose Metabolismmentioning

confidence: 99%

Acupuncture Attenuates Hyperglycaemia and Improves Ovarian Function in Female Rats Subjected to Continuous Light Exposure

Kang

et al. 2017

Acupunct Med

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Objective Exposure to unnatural light cycles is increasingly associated with obesity and the metabolic syndrome. The purpose of this study was to examine the effects of electroacupuncture (EA) on glucose metabolism and ovarian function in female rats subjected to longterm continuous light exposure. Methods Female Sprague-Dawley rats (n=24) were divided into three experimental groups: an LD group that was maintained under a normal light-dark cycle (healthy control); an LL group that was exposed to continuous light for 21 weeks but remained untreated; and an LL+EA group that received EA at ST36 and SP6 during weeks 17 to 21 of continuous light exposure. Results Oestrous cycles of female rats kept in a continuously lit environment for 21 weeks were disordered and polycystic ovarian syndrome (PCOS)-like changes occurred, accompanied by increased fasting blood glucose (6.23±0.33 vs 5.27±0.40 mmol/L in week 17, p=0.015) and reduced fasting levels of serum testosterone (0.07±0.018 vs 0.12±0.058 ng/L, p=0.043) and insulin (0.89±0.20 vs 1.43±0.46 ng/L, p=0.006). After 5 weeks of EA treatment at ST36 and SP6, ovarian cycle disruption was mitigated and blood glucose levels showed a gradual decline (5.18±0.37 vs 5.80±0.55 mmol/L, p=0.017; and 5.73±0.31 vs 6.62±0.13 mmol/L, p=0.004; in the fourth and fifth weeks of EA treatment, respectively). EA also attenuated the reductions otherwise seen in serum insulin and testosterone levels. Conclusion Prolonged exposure to light can lead to a decline in ovarian and pancreatic function. EA at ST36 and SP6 may reduce abnormally elevated blood glucose levels and improve ovarian and pancreatic hormone levels. InTRoduCTIonHuman circadian rhythms are synchronised to light/dark cycles. Over time, organisms have adapted to diurnal variations in their physiology and metabolism. These rhythms are regulated by molecular circadian clocks. However, in recent years, humans have shifted away from the naturally occurring solar light cycle in favour of artificial, irregular light schedules produced by electrical lighting. Disruption of the core clock genes secondary to interference with these environmental considerations may lead to an increased risk of cardiometabolic disease.1 2 Genetic disruption of clock genes in mice induces metabolic dysfunction at distinct phases of the sleep/ wake cycle.3 Constant exposure to light induces alterations in melatonin levels, food intake, visceral adiposity and circadian rhythms in rats. 4 Exposure of adult female rats to continuous light leads to the gradual development of chronic anovulation.5 6 However, it remains unknown how continuous light exposure affects glucose levels in female rats.As contemporary exposure to artificial light environments is unlikely to change, there may be a potential role for complementary and alternative medicine (CAM) in allowing humans to enjoy the convenience of artificially lit environments, while reducing the potential side effects of light exposure to a minimum. Acupuncture is now widely practised in both East Asian an...

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Section: Ea Simultaneously Improved Ovarian Cycle and Glucose Metabolismmentioning

confidence: 99%

Acupuncture Attenuates Hyperglycaemia and Improves Ovarian Function in Female Rats Subjected to Continuous Light Exposure

Kang

et al. 2017

Acupunct Med

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“…Wang et al and Zhou et al investigated effect of acupuncture on E2 level in human with diminished ovarian reserve and primary ovarian insufficiency, respectively [20, 22]. E2 level was increased in compliance with acupuncture treatment in the both studies.…”

Section: Resultsmentioning

confidence: 99%

A Literature Review of Women’s Sex Hormone Changes by Acupuncture Treatment: Analysis of Human and Animal Studies

Kim

2018

Evidence-Based Complementary and Alternative Medicine

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Background It has been known that acupuncture treatment relieves gynecological disorders such as menopause, ovarian dysfunction, and dysmenorrhea. Sex hormones, including estrogen, progesterone, and gonadotropins, are related to the women disease. However, regulative effect of acupuncture on sex hormones has not been fully identified. Methods Acupuncture articles including analysis of sex hormones were searched in electronic databases from inception to June 2018. The methodological quality was assessed using modified CAMRADES tool. A total of 23 articles were selected and analyzed. Results In the results, overall studies showed that acupuncture increases estrogen, especially estradiol, progesterone, prolactin, and other hormones. Estradiol level was increased in most of studies except 3 studies which resulted in decreased level or not meaningful change. Two studies showed increase of FSH and LH whereas it was decreased in other studies. Other hormones were mostly increased by acupuncture. Conclusion This study possibly indicates that acupuncture changes sex hormone in various gynecological conditions in women.

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“…Although there are few studies on the effects of acupuncture on children's sexual development and secondary sexual signs, there are relevant clinical and basic researches on the effects of acupuncture on adult women's reproductive endocrine function [19,20]; literature studies have shown that acupuncture treatment can reduce the serum FSH and LH levels of adult women, improve the E2 level of women, and improve menstrual cycle and ovarian function [21,22]; acupuncture has been applied to primary ovarian dysfunction [23], polycystic ovarian syndrome [24], [25], dysmenorrhea [26], and other female reproductive endocrine-related diseases. Although the mechanism of acupuncture on female reproductive endocrine system is not very clear at present, it has been found that acupuncture can regulate some neurotransmitters and neuropeptides, such as β-endorphin, dopamine, and prostaglandin [27][28][29] and then affect the hypothalamic pituitary gonadal axis, thus regulating the level of serum sex hormones [30].…”

Section: Discussionmentioning

confidence: 99%

Acupuncture Improving Early Sexual Development of Girls with Peripheral Precocious Puberty: A Prospective Cohort Study

Liu

Wan

Sun

2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To study primarily on the effect of acupuncture on breast Tanner stage, serum sex hormone level, and TCM symptom scores in girls with peripheral precocious puberty (PPP). Methods. 19 eligible patients diagnosed with PPP received acupuncture intervention for 12 weeks, twice a week for 12 weeks, 24 sessions of acupuncture treatment in all, and then follow-up for 12 weeks. The primary outcome was the change in serum luteinizing hormone (LH) level, follicle-stimulating hormone (FSH) level, and breast Tanner stage at 12-week treatment and 12-week follow-up. Serum estradiol (E2) level and TCM symptom scores were also assessed. Results. Nineteen patients with peripheral precocious puberty were treated with acupuncture. After the 12-week acupuncture intervention, the serum LH level, breast Tanner stage, and TCM symptom scores decreased significantly compared with baseline (P<0.05); the serum FSH and E2 level did not change significantly after the 12-week treatment (P>0.05). After the 12-week follow-up, breast Tanner stage and TCM symptom scores decreased significantly compared with baseline (P<0.05), and there was no statistical difference between serum sex hormone (LH, FSH, and E2) level and baseline level (P>0.05). During the period of acupuncture treatment, no side effects or serious adverse events occurred. Conclusions. Acupuncture is effective in regulating the hormone level and controlling early development process. It may be a viable alternative to the treatment of peripheral precocious puberty in girls. However, further randomized controlled trials are needed.

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Electroacupuncture for Reproductive Hormone Levels in Patients with Diminished Ovarian Reserve: A Prospective Observational Study

Cited by 34 publications

References 24 publications

Acupuncture Attenuates Hyperglycaemia and Improves Ovarian Function in Female Rats Subjected to Continuous Light Exposure

Acupuncture Attenuates Hyperglycaemia and Improves Ovarian Function in Female Rats Subjected to Continuous Light Exposure

A Literature Review of Women’s Sex Hormone Changes by Acupuncture Treatment: Analysis of Human and Animal Studies

Acupuncture Improving Early Sexual Development of Girls with Peripheral Precocious Puberty: A Prospective Cohort Study

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