2018
DOI: 10.1155/2018/8919347
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Electroacupuncture Improves Baroreflex and γ-Aminobutyric Acid Type B Receptor-Mediated Responses in the Nucleus Tractus Solitarii of Hypertensive Rats

Abstract: Electroacupuncture (EA) has been reported to benefit hypertension, but the underlying mechanisms are still unclear. We hypothesized that EA attenuates hypertension, in part, through modulation of γ-aminobutyric acid (GABA) receptor function in the nucleus tractus solitarii (NTS). In the present study, the long-term effect of EA on GABA receptor function and expression was examined in the NTS of two-kidney, one-clip (2K1C) renovascular hypertensive rats. EA (0.1–0.4 mA, 2 and 15 Hz) was applied at Zusanli (ST36… Show more

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Cited by 15 publications
(20 citation statements)
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“…In a recent paper, Zhang and collaborators (Zhang et al. ) showed that electroacupuncture attenuated the increased GABA B receptor expression within the NTS, reduced blood pressure, and improved baroreflex function in renal hypertensive rats. Although it is possible that reduced GABA B expression/activity could contribute to training‐induced effects on PVN GABAergic neurotransmission, this effect remains to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…In a recent paper, Zhang and collaborators (Zhang et al. ) showed that electroacupuncture attenuated the increased GABA B receptor expression within the NTS, reduced blood pressure, and improved baroreflex function in renal hypertensive rats. Although it is possible that reduced GABA B expression/activity could contribute to training‐induced effects on PVN GABAergic neurotransmission, this effect remains to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…The role of GABA-B in the ACC has been found to be associated in mechanical hypersensitivity and GABA-B receptors are involved in the morphine-induced and muscarinic M1 receptor-mediated analgesia (Migita et al, 2018; Pedrón et al, 2019). Hence, Zhang Q. et al (2018) demonstrated that GABA-B receptors in the NTS may be regulated by EA manipulation. However, sensitivity bias of GABA-A and GABA-B receptors in supraspinal structures warrants further investigation and that detail is beyond the scope of the present review article.…”
Section: Other Transmitters Related To Ea-induced Analgesiamentioning
confidence: 99%
“…Sprague-Dawley rats were randomly divided into four groups after 1 week of adaptation: the sham group (Sham, n = 12), sham plus EA treatment group (Sham+EA, n = 12), 2K1C hypertensive group (2K1C, n = 16), and 2K1C plus EA treatment group (2K1C+EA, n = 16). The 2K1C hypertensive model was established as previously described (Zhang et al, 2018). Briefly, the rats were anesthetized with pentobarbital (i.p., 40 mg/kg), and the adequacy of anesthesia was evaluated by the loss of a pedal withdrawal reflex.…”
Section: Methodsmentioning
confidence: 99%
“…Four weeks after 2K1C or sham surgery, the EA treatment was applied as previously described (Tan et al, 2016; Tao et al, 2016; Zhang et al, 2018). Rats were adapted and handled gently for 30 min each day, for 3 days before the beginning of the experiment.…”
Section: Methodsmentioning
confidence: 99%
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