Electroacupuncture Improves Insulin Resistance by Reducing Neuroprotein Y/Agouti-Related Protein Levels and Inhibiting Expression of Protein Tyrosine Phosphatase 1B in Diet-induced Obese Rats

Liu, Xia; He, Jianbin; Qu, Yating; Liu, Zhijun; Pu, Qing-Yang; Guo, Shengtong; Du, Junjie; Pengfei, Jiang

doi:10.1016/j.jams.2015.11.037

Cited by 11 publications

(6 citation statements)

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“…One study [ 44 ] showed that downregulation of ghrelin in the stomach and neuropeptide Y (NPY) in the hypothalamus was in line with the reduction in food intake in rats receiving EA stimulation once every day. Liu et al [ 45 ] speculated that, in high-fat diet (HFD) animals, EA treatment (ST36 and LI11, 20 minutes per day for 28 days) could reduce the body weight, homeostasis model assessment-insulin resistance index, adipocyte diameters, and neuroprotein Y/agouti-related protein and protein tyrosine phosphatase 1B levels. In db/db mice, Liang et al [ 46 ] found that EA treatment (five times per week for eight weeks) contracted the increase of fasting blood glucose, food intake, and body mass and maintained insulin levels via stimulation of skeletal muscle Sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1 α ), suggesting the role of EA in improving insulin resistance.…”

Section: Resultsmentioning

confidence: 99%

Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms

Zhang

Zhou

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objective Acupuncture, as one of the complementary and alternative medicines, represents an efficient therapeutic option for obesity control. We conducted a meta-analysis to investigate the effectiveness of acupuncture in obesity and also summarized the available studies on exploring the mechanisms. Design We searched six databases from the inception to April 2017 without language restriction. Eligible studies consisted of acupuncture with comparative controls ((1) sham acupuncture, (2) no treatment, (3) diet and exercise, and (4) conventional medicine). The primary outcomes consisted of BMI, body weight reduction, and incidence of cardiovascular events (CVD). Secondary outcomes included waist circumference (WC), waist-to-hip ratio (WHR), body fat mass percent, body fat mass (kg), total cholesterol (TC), triglyceride (TG), glucose, low density lipoprotein cholesterol (LDL-c) reduction, high density lipoprotein cholesterol (HDL-c) increase, and adverse effects. The quality of RCTs was assessed by the Cochrane Risk of Bias Tool. Subgroup analyses were performed according to types of acupuncture. A random effects model was used to adjust for the heterogeneity of the included studies. Publication bias was assessed using funnel plots. Main Results We included 21 studies with 1389 participants. When compared with sham acupuncture, significant reductions in BMI (MD=-1.22, 95%CI=-1.87 to -0.56), weight (MD=-1.54, 95%CI=-2.98 to -0.11), body fat mass (kg) (MD=-1.31, 95%CI=-2.47 to -0.16), and TC (SMD=-0.63, 95%CI=-1.00 to -0.25) were found. When compared with no treatment group, significant reductions of BMI (MD=-1.92, 95%CI=-3.04 to -0.79), WHR (MD=-0.05, 95%CI=-0.09 to -0.02), TC (MD=-0.26, 95%CI=-0.48 to -0.03), and TG (MD=-0.29 95%CI=-0.39 to -0.18) were found. When compared with diet and exercise group, significant reduction in BMI (MD=-1.24, 95%CI=-1.87 to -0.62) and weight (MD=-3.27 95%CI=-5.07 to -1.47) was found. Adverse effects were reported in 5 studies. Conclusions We concluded that acupuncture is an effective treatment for obesity and inferred that neuroendocrine regulation might be involved.

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Section: Resultsmentioning

confidence: 99%

Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms

Zhang

Zhou

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, based on the data obtained in our study, the mechanism for preventing weight gain in oleacein-treated mice may be related to the amelioration of insulin resistance and the prevention of metabolic dysfunction. Weight loss related to improved insulin resistance and insulin sensitivity has been reported in diet-induced obese rats in which changes in the size of adipocytes and reduction in fat tissue were observed ( 34 ). An alternative, unexplored hypothesis, compatible with our findings, is that oleacein, like metformin ( 35 ), the first-line drug for treatment of insulin-resistant diabetes, may act by increasing energy expenditure, thus preventing weight gain.…”

Section: Discussionmentioning

confidence: 97%

Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice

et al. 2018

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Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet, against metabolic and cardiovascular diseases, can be attributed to the action of polyphenolic components of extra-virgin olive oil (EVOO). Here, we evaluated the protective effects of oleacein, one of the most abundant secoiridoids in EVOO, on the damages/metabolic alterations caused by high-fat diet (HFD) in male C57BL/6JolaHsd mice. After 5 weeks of treatment with 20 mg/kg of oleacein, body weight, glycemia, insulinemia, serum lipids, and histologic examination of liver tissue indicated a protective action of oleacein against abdominal fat accumulation, weight gain, and liver steatosis, with improvement of insulin-dependent glucose and lipid metabolism. Both serum parameters and hepatic histologic examination were altered in mice fed with HFD. By contrast, in the animals that received oleacein, plasma glucose, cholesterol and triglyceride serum levels, and liver histology were similar to controls fed with normocaloric diet. In addition, protein levels of FAS, SREBP-1, and phospho-ERK in liver were positively modulated by oleacein, indicating an improvement in liver insulin sensitivity. In a group of obese mice, treatment with oleacein determined a light, but still significant reduction of the increase in body weight, mainly due to lesser liver steatosis enlargement, associated with reduced levels of SREBP-1 and phospho-ERK and lower levels of total serum cholesterol; in these animals, altered plasma glucose and triglyceride serum levels were not reverted by oleacein. These results indicate that HFD-related hepatic insulin resistance may be partially prevented by oral administration of oleacein, suggesting a protective role of this nutraceutical against diet-dependent metabolic alterations. Additional studies are necessary to check whether oleacein can be used as an adjuvant to improve insulin sensitivity in humans.

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“…Acupuncture, a form of TCM, has been previously reported effective in treating obesity [29][30][31][32]. Furthermore, recent years have witnessed an increasing number of clinical studies concerning the treatment of obesity using electroacupuncture [33][34][35]. Electroacupuncture was found to promote fat metabolism via sympathetic nervous system activation, thus decreasing appetite [36].…”

Section: Total (95% Ci)mentioning

confidence: 99%

Effectiveness of Electroacupuncture for Simple Obesity: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Gao

Wang

Zhou

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the effectiveness of electroacupuncture in the treatment of simple obesity. Methods. Randomized clinical trials concerning electroacupuncture as a treatment of simple obesity published prior to October 31, 2019, were searched in the following Chinese and English databases: Chinese National Knowledge Infrastructure (CNKI), WanFang Database, China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Cochrane Library, Web of Science, and Scopus. After data collection and quality evaluation, meta-analysis was performed using RevMan 5.3 software and Stata 15.0 software. Results. A total of 13 studies involving 937 patients with simple obesity were included in the meta-analysis. Results revealed that the total effective rate (RR = 1.29, 95% CI [1.13, 1.48]; P=0.0002), BMI (MD = −1.82, 95% CI [−2.21, −1.43]; P<0.000), waist circumference (MD = −2.39, 95% CI [−3.95, −0.84]; P=0.003), hip circumference (MD = 0.31, 95% CI [−2.37, 2.99]; P=0.82), waist-hip ratio (MD = −0.05, 95% CI [−0.07, −0.03]; P<0.00), and body fat rate (MD = −1.56, 95% CI [−2.35, −0.78]; P=0.0001) in the electroacupuncture group were superior to those in the control group. Analysis of acupoint clustering and correlation using SPSS 24.0 and Clementine 12.0 revealed the highest statistical support for acupoint groups CV12-CV4 and CV12-ST25-CV4, while ST36-CV12-ST25, SP6, and ST40-ST24-SP15-ST37-CV4 were found to be validly clustered acupoints. Conclusion. For treating simple obesity, electroacupuncture is superior to other interventions such as acupuncture, acupoint catgut embedding therapy, and simple lifestyle modification for improvement in body fat rate, waist circumference, and waist-hip ratio, although not hip circumference. Acupoint analysis revealed that ST25, CV12, CV4, SP6, and ST36 can form the basis for electroacupuncture therapy for the treatment of simple obesity.

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Electroacupuncture Improves Insulin Resistance by Reducing Neuroprotein Y/Agouti-Related Protein Levels and Inhibiting Expression of Protein Tyrosine Phosphatase 1B in Diet-induced Obese Rats

Cited by 11 publications

References 28 publications

Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms

Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms

Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice

Effectiveness of Electroacupuncture for Simple Obesity: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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