Electroacupuncture Improves Learning and Memory Abilities via Activating AMPK/mTOR-Induced Autophagy in APP/PS1 Mice

Wan, Wenjun; Wang, Ying; Li, Lei; Ma, Chaoyang; Wang, Yanfu; You, Fei

doi:10.1007/s10528-023-10503-9

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Previous studies have con rmed that mTOR inhibitors are autophagy enhancers that can reduce Tau tangles, improve neuroin ammation, and reverse cognitive impairment in the body (Pei et al, 2023). Adenylate-activated protein kinase (AMPK) not only plays an important role in maintaining cell energy balance, but also affects the process of autophagy through multiple pathways in cells, the most important of which is the cytoplasmic AMPK-mTOR signal pathway, which has been widely studied (Hou et al, 2020;Wan et al, 2023). Activated AMPK can down-regulate mTOR signal by directly phosphorylating the regulation-related protein (Raptor) of mTOR, thus enhancing autophagy (Song et al, 2021;Chen et al, 2023b).…”

Section: Introductionmentioning

confidence: 99%

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR

Gong,

Xu,

et al. 2024

Preprint

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Alzheimer's disease (AD) is a progressive neurodegenerative brain disease. At present, the main treatment strategy is to alleviate certain symptoms, but the potential mechanisms of AD are not fully understood, and there is a lack of effective treatment methods in clinical practice. Quercetin (QT) can significantly protect neurodegeneration by inhibiting oxidative stress and inflammation, and has the potential to play a greater role in clinical practice. Therefore, this study aims to explore the potential mechanism of QT based on the AMPK/mTOR pathway in improving the learning and memory abilities of AD rats.For this purpose,we established an AD rat model by injecting Hcy into the tail vein.After successful model validation, Quercetin and AMPK inhibitor were gavaged.Then, the role of the AMPK/mTOR pathway in QT protected nerve regeneration was determined using Morris water maze, Nissl staining, Western blot and immunohistochemistry.We observed that QT significantly improved the learning and memory abilities in rat models with AD, as demonstrated by the short learning latency and greater times of travel across the platform. Nissl staining showed that QT could reduce neurological Apoptosis and amenorrate neurological implementation .Western blot and immunohistochemistry staining showed that questionnaire significantly increased p-AMPK, while reducing p-mTOR and p-Tau .In addition, the application of specific AMPK inhibitor can effectively reverse these changes, further enhancing the improvement effect of QT inhibition on AD, Thereby improving the learning and memory improvement induced by Hcy in AD model rates, and thus improving learning and memory abilities.

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Section: Introductionmentioning

confidence: 99%

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR

Gong,

Xu,

et al. 2024

Preprint

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Study on the Effects of Acupuncture with the “Yizhi Tiaoshen” Acupoint Formula on Blood Oxygen Metabolism and Neural Function in Key Brain Regions of AD Rats

Zhang,

Zhu

et al. 2024

DNND

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Purpose Exploring the effects of acupuncture at the “Yizhi Tiaoshen” acupoint on blood oxygen metabolism and neurological function changes in the brain regions of AD model rats. Methods The AD model was replicated by intraperitoneal injection of D-galactose combined with bilateral hippocampal CA1 injection of Okadaic acid (OA). Thirty rats with successfully replicated model were selected through Morris water maze experiment and randomly divided into model group, donepezil hydrochloride group, and acupuncture group, with 10 rats in each group. After treatment, fNIRs were used to detect changes in Oxy Hb, Deoxy Hb, and Total Hb in the cerebral cortex of rats in each group, in order to evaluate the neurological function changes in key brain areas. Results The escape latency of the donepezil hydrochloride group and the acupuncture group was shortened, the number of crossings through the original platform increased, and the duration of stay in the quadrant where the original platform was located was prolonged. Based on fNIRs detection, the main differential channels of blood oxygen metabolism in AD rats were identified as 2–2 and 8–7, corresponding to the prefrontal and parietal lobes, respectively. The concentrations of Oxy Hb and Total Hb were significantly increased in both treatment groups, while the concentration of Deoxy Hb was significantly decreased. Conclusion Acupuncture with the “Yizhi Tiaoshen” acupoint formula and donepezil hydrochloride can improve the learning and memory function of AD rats, and its mechanism may be related to improving blood oxygen metabolism in the prefrontal and parietal regions and protecting neuronal function.

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Electroacupuncture Improves Learning and Memory Abilities via Activating AMPK/mTOR-Induced Autophagy in APP/PS1 Mice

Cited by 2 publications

References 38 publications

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR

Study on the Effects of Acupuncture with the “Yizhi Tiaoshen” Acupoint Formula on Blood Oxygen Metabolism and Neural Function in Key Brain Regions of AD Rats

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