Electroacupuncture improves metabolic and ovarian function in a rat model of polycystic ovary syndrome by decreasing white adipose tissue, increasing brown adipose tissue, and modulating the gut microbiota

Zhang, Feifei; Ma, Tong; Tong, Xiaoyu; Liu, Yanjun; Cui, Peng; Xu, Xiaoqing; Shi, Jiemei; Hu, Wei; Lu, Wenhan; Pei, Zhenle; Xu, Minzhen; Li, Xin; Xu, Congjian; Feng, Yi

doi:10.1177/09645284211056663

Cited by 18 publications

(9 citation statements)

References 46 publications

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“…Past studies have suggested that EA could modulate intestinal microecology and protect the intestinal barrier [ 41 – 43 ]. Zhang et al showed that EA regulated the metabolic disorders and improved reproductive function in this PCOS-like rat model by adjusting intestinal microbiota [ 24 ]. Similarly, we found that EA has positive effects on both restoration of the percentage of normal follicles and improvement of intestinal microbiota disturbance.…”

Section: Discussionmentioning

confidence: 99%

“…Some underlying mechanisms of EA for POF have been confirmed that EA could inhibit follicular loss, activate serum anti-Müllerian hormone (AMH), and enhance activation of antioxidative and antiapoptotic [21][22][23]. In addition, EA can improve reproductive function by reshaping and adjusting the abundance of the intestinal microbiota [24]. But whether EA can regulate the intestinal microbiota of POF remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Electroacupuncture May Inhibit Oxidative Stress of Premature Ovarian Failure Mice by Regulating Intestinal Microbiota

Geng

Nie

Ling

et al. 2022

Oxidative Medicine and Cellular Longevity

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Premature ovarian failure (POF) is the leading cause of female infertility, and there is no optimal treatment or medication available currently. For POF, electroacupuncture (EA) has been considered a promising therapeutic approach, but the mechanism for this is not clear. In this study, we explored the effects of EA (CV4, ST36, and SP6) on oxidative stress and intestinal microbiota of high-fat and high-sugar- (HFHS-) induced POF mice. The development of mice follicles was observed by hematoxylin and eosin (HE) staining. The serum levels of estrone (E1), estrogen (E2), estriol (E3), and 21-deoxycortisol (21D) were measured by the HPLC-MS/MS method. The concentrations of Fe2+, superoxide dismutase (SOD), hydroxyl radical (·OH), glutathione (GSH), superoxide anion, and malondialdehyde (MDA) were measured by spectrophotometry. The 16S-rDNA sequencing was used to measure many parameters related to the host gut bacteriome and mycobiome composition, relative abundance, and diversity. mRNA expression levels of ferroptosis-related genes were determined by RT-qPCR. After 4 weeks of EA intervention in POF mice, mature follicles were increased and the levels of the sex hormone were improved. SOD activities, antisuperoxide activities, and GSH increased while MDA, ·OH, and Fe2+ decreased. In addition, EA also altered the intestinal microbiota. These results reveal that EA can effectively inhibit ovarian oxidative stress and the accumulation of Fe2+ in POF mice. It may be that the alteration in the intestinal microbiota is one of the potential mechanisms of EA treatment. These findings suggest that EA has clinical potential as a safe treatment for POF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electroacupuncture May Inhibit Oxidative Stress of Premature Ovarian Failure Mice by Regulating Intestinal Microbiota

Geng

Nie

Ling

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…In addition, the gut microbiota is known to be causal in the development of obesity/insulin resistance ( 111 ). A recent study showed that EA intervention decreased body weight, probably through regulating gut microbiota in PCOS rats ( 112 ). This study also demonstrated that EA can normalize visceral and subcutaneous fat content, brown adipose tissue weight, and glucose tolerance in the PCOS model.…”

Section: Potential Mechanisms Of Acupuncture Affecting Pcos-related S...mentioning

confidence: 99%

Underlying mechanisms of acupuncture therapy on polycystic ovary syndrome: Evidences from animal and clinical studies

Yang

Zhou²,

Hu³

et al. 2022

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of reproductive age. Current standard treatment includes lifestyle change, oral pharmacological agents, and surgical modalities. However, the efficacy of current therapies is less than satisfactory. Clinical evidence has shown that acupuncture is effective for regulating hormone levels, promoting ovulation, and attenuating insulin resistance in patients with PCOS. Acupuncture may affect the production of β‐endorphin, which may lead to gonadotropin-releasing hormone secretion and then affect ovulation, menstrual cycle, and fertility. The mechanism of acupuncture for patients with PCOS has not been comprehensively reviewed so far. Better understanding of the mechanisms of acupuncture would help popularize the use of acupuncture therapy for patients with PCOS. In this narrative review, we aimed to overview the potential mechanisms and evidence-based data of acupuncture on PCOS, and analyze the most frequently used acupoints based on animal and clinical studies. The results of this study will contribute to a better understanding of the current situation in this field.

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“…Acupuncture and Chinese herb medicines (CHMs) have signi cant e cacy in improving menstruation [7], ovulation [6][8], pregnancy [7][8] [9] [21], body weight [9], insulin resistance [9][10] [11] [24], sex hormones [7][23] [24] regulation of intestinal ora [9] [20], mood [12], and sleep in patients with PCOS. Therefore, Chinese medicine treatments have a wide range of positive signi cance for patients with polycystic ovary syndrome.…”

Section: Introductionmentioning

confidence: 99%

The "tonifying the kidneys, resolving blood stasis and clearing collaterals" method in polycystic ovary syndrome (PCOS) research: study protocol for a multicentre cohort study nested randomised controlled trials

Song,

liu,

Yang

et al. 2024

Preprint

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Introduction: Polycystic ovary syndrome (PCOS) presents as a multi-complicated syndrome and increases the risk of other diseases. Life management is clinically ineffective as a first-line basic treatment for polycystic ovary syndrome. Acupuncture and Chinese herbal medicine (CHM) have excellent clinical efficacy for PCOS. however,there is currently a dearth of high-quality data demonstrating its efficacy.The purpose of this experiment is to assess the safety and efficacy, especially the long-term efficacy,of individualized life management、CHM, acupoint thread-embedding therapy for treating PCOS. Methods and analysis: We present a multicentre, prospective, combined randomised clinical trial and observational cohort study design, with a target sample size of 316 patients with PCOS of the kidney deficiency and blood stasis type aged between 18-45years. Patients were divided into an observational cohort with a renal supplementation and blood-stasis-restoration cohort based on whether or not they were exposed to the tonifying-kidney, resolving-blood stasis-and-tongue method. Based on the examination results, the observation cohort received individualised life management and appropriate pharmacological interventions and was followed up for 6 months. The kidney tonifying and resolving stasis through the channels cohort was randomly divided into A) Kidney tonifying and resolving stasis traditional Chinese medicine group, B) Kidney tonifying and resolving stasis buried under ultrasound in the musculoskeletal bone group, and C) Kidney tonifying and resolving stasis traditional Chinese medicine combined with burying group by the method of randomised numerical table based on the above. The kidney tonifying and resolving stasis through the channels cohort treatment cycle was 3 months, and the follow-up period was 3 months. Main results: (1) the change of menstrual of PCOS patients before and after treatment ; (2) the efficacy of traditional Chinese medicine symptoms. Secondary results: Sex hormones, AMH, ultrasound;changes in scores such as polycystic cognition,PCOSQ-50 score,menstruation,hirsutism,Ffq168,IPAQ-SFHADS etc.All assessments were followed up with redcap questionnaires at baseline at weeks 4, 8, and 12 after the start of the intervention and at weeks 16, 20, and 24 after the end of the intervention. Trial registration number: (2023) Lun Shen No.41; Pre-results.The trial was launched on July 2023 through https://www.chictr.org.cn/ Registrationnumber:ChiCTR2300073832.

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Electroacupuncture improves metabolic and ovarian function in a rat model of polycystic ovary syndrome by decreasing white adipose tissue, increasing brown adipose tissue, and modulating the gut microbiota

Cited by 18 publications

References 46 publications

Electroacupuncture May Inhibit Oxidative Stress of Premature Ovarian Failure Mice by Regulating Intestinal Microbiota

Electroacupuncture May Inhibit Oxidative Stress of Premature Ovarian Failure Mice by Regulating Intestinal Microbiota

Underlying mechanisms of acupuncture therapy on polycystic ovary syndrome: Evidences from animal and clinical studies

The "tonifying the kidneys, resolving blood stasis and clearing collaterals" method in polycystic ovary syndrome (PCOS) research: study protocol for a multicentre cohort study nested randomised controlled trials

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