Electroacupuncture Induces Bilateral S1 and ACC Epigenetic Regulation of Genes in a Mouse Model of Neuropathic Pain

Ping, Xingjie; Xie, Junkai; Yuan, Ching; Jin, Xiaoming

doi:10.3390/biomedicines11041030

Cited by 4 publications

(2 citation statements)

References 76 publications

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“…Acupuncture could restore both the DNA hypomethylation in the prefrontal cortex and the nociceptive hyperresponsiveness. In a mouse model of neuropathic pain based on unilateral transection of the tibial nerve, global DNA methylation was increased bilaterally in the primary somatosensory cortex [24].…”

Section: Global Changes In Dna Methylation Under Neuropathic Conditionsmentioning

confidence: 99%

The Epigenetics of Neuropathic Pain: A Systematic Update

Pethő,

Kántás,

Horváth

et al. 2023

IJMS

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Epigenetics deals with alterations to the gene expression that occur without change in the nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the surrounding histone proteins have been revealed, including DNA methylation, histone acetylation, and methylation, which can either stimulate or inhibit protein expression at the transcriptional level. In the past decade, an exponentially increasing amount of data has been published on the association between epigenetic changes and the pathomechanism of pain, including its most challenging form, neuropathic pain. Epigenetic regulation of the chromatin by writer, reader, and eraser proteins has been revealed for diverse protein targets involved in the pathomechanism of neuropathic pain. They include receptors, ion channels, transporters, enzymes, cytokines, chemokines, growth factors, inflammasome proteins, etc. Most work has been invested in clarifying the epigenetic downregulation of mu opioid receptors and various K+ channels, two types of structures mediating neuronal inhibition. Conversely, epigenetic upregulation has been revealed for glutamate receptors, growth factors, and lymphokines involved in neuronal excitation. All these data cannot only help better understand the development of neuropathic pain but outline epigenetic writers, readers, and erasers whose pharmacological inhibition may represent a novel option in the treatment of pain.

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Section: Global Changes In Dna Methylation Under Neuropathic Conditionsmentioning

confidence: 99%

The Epigenetics of Neuropathic Pain: A Systematic Update

Pethő,

Kántás,

Horváth

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Popular mechanisms for peripherally mediated analgesic activity include inhibition of prostaglandin synthesis, GMP-ATP-sensitive K+ channel cascade, serotonergic pathway, adrenergic pathway, inhibition of cytokine production, L-Arginine-Nitric Oxide pathway amongst others. 38,39…”

Section: Mechanistic Studymentioning

confidence: 99%

Anti-inflammatory, Analgesic and GCMS Analysis of Ethanol Extract of a Polyherbal Phytomedicine Used in Nigerian Ethnomedicine

2023

TJNPR

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The use of non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, and corticosteroids had been the treatment approach for inflammation via the inhibition of cyclooxygenase 2 (COX2). However, long-term usage threatens the human organs such as the liver, kidneys and the gastrointestinal tract due to their side effects. 3 Hence, the need for an alternative with lesser or no adverse effect while proffering a comparable therapeutic effect for the treatment of inflammation cannot be overemphasized. Traditional remedies have recently gained increased acceptance and application in Africa as inflammatory-related diseases, epidemics, and pandemics appear to be on the increase. 4 Medicinal plants have proved to be an excellent alternative to conventional medicines due to their richness in diverse types of phytochemicals and micronutrients such as alkaloids, flavonoids, terpenes, tannins, saponins, zinc, iron etc. These phytochemicals are responsible for the therapeutic activities of medicinal plants such as antioxidant, antimicrobial, antidiabetic, anticancer, neuroprotective effects. 3,4 Ginger -Zingiber officinale Roscoe (family Zingiberaceae) is one of the plants prominently used for several disease management. It is abundant in different bioactive compounds and minerals. Its fresh form contains mainly gingerols (6-gingerol, 8-gingerol, and 10-gingerol), which are converted to shogaols after heating, 5 and finally to paradols upon hydrogenation. In addition to the gingerols and its derivatives, there are also several other phenols in ginger such as zingerone,

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Map activation of various brain regions using different frequencies of electroacupuncture ST36, utilizing the FosCreER strategy

Guo,

Wei,

et al. 2024

Acupuncture and Herbal Medicine

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Objective: Electroacupuncture (EA) is an alternative treatment option for pain. Different frequencies of EA have different pain-relieving effects; however, the central mechanism is still not well understood. Methods: The FosTRAP:Ai9 mice were divided into three groups (sham, 2 Hz, and 100 Hz). The mice were intraperitoneally injected with 4-hydroxytamoxifen (4-OHT) immediately after EA at Zusanli (ST36) for 30 min to record the activated neurons. One week later, the mice were sacrificed, and the number of TRAP-treated neurons activated by EA in the thalamus, amygdala, cortex, and hypothalamus was determined. Results: In the cortex, 2 Hz EA activated more TRAP-treated neurons than 100 Hz EA did in the cingulate cortex area 1 (Cg1) and primary somatosensory cortex (S1), and 2 Hz and 100 Hz EAs did not differ from sham EA. TRAP-treated neurons activated by 2 Hz EA were upregulated in the insular cortex (IC) and secondary somatosensory cortex (S2) compared with those activated by 100 Hz and sham EA. In the thalamus, the number of TRAP-treated neurons activated by 2 Hz EA was elevated in the paraventricular thalamic nucleus (PV) compared with those activated by sham EA. In the ventrolateral thalamic nucleus (VL), the number of TRAP-treated neurons activated by 2 Hz EA was significantly upregulated compared with those activated by 100 Hz EA, and sham EA showed no difference compared to 2 Hz EA or 100 Hz EA. TRAP-treated neurons were more frequently activated in the ventral posterolateral thalamic nucleus (VPL) by 2 Hz EA than by 100 Hz or sham EA. Conclusion: Low-frequency EA ST36 effectively activates neurons in the Cg1, S1, S2, IC, VPL, PV, and VL. The enhanced excitability of the aforementioned nuclei induced by low-frequency EA may be related to its superior efficacy in the treatment of neuropathological pain.

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Electroacupuncture Induces Bilateral S1 and ACC Epigenetic Regulation of Genes in a Mouse Model of Neuropathic Pain

Cited by 4 publications

References 76 publications

The Epigenetics of Neuropathic Pain: A Systematic Update

The Epigenetics of Neuropathic Pain: A Systematic Update

Anti-inflammatory, Analgesic and GCMS Analysis of Ethanol Extract of a Polyherbal Phytomedicine Used in Nigerian Ethnomedicine

Map activation of various brain regions using different frequencies of electroacupuncture ST36, utilizing the FosCreER strategy

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