Electroacupuncture promotes the survival and synaptic plasticity of hippocampal neurons and improvement of sleep deprivation‐induced spatial memory impairment

Abstract

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Electro‐acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of literature

“…EA pretreatment also can increase ambient endocannabinoid levels and result in activation of the ischemic penumbral astroglial cannabinoid type 1 receptor, which led to moderate upregulation of extracellular glutamate that protected neurons from cerebral ischemic injury 32 . In addition, EA can promote the survival and synaptic plasticity of hippocampal neurons and improve spatial memory disorders caused by sleep deprivation 33 . Interestingly, a previous research suggested that EA protected cerebral hippocampal neurons in vascular dementia by inhibiting the expression of p53 (a tumor suppressor) and Noxa (p53 downstream effector) in hippocampal CA1 region 34 .…”

“… 32 In addition, EA can promote the survival and synaptic plasticity of hippocampal neurons and improve spatial memory disorders caused by sleep deprivation. 33 Interestingly, a previous research suggested that EA protected cerebral hippocampal neurons in vascular dementia by inhibiting the expression of p53 (a tumor suppressor) and Noxa (p53 downstream effector) in hippocampal CA1 region. 34 In response to EA, neurons synthesize and secrete specific proteins and neuropeptides that transduce the electrical signals.…”

The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

“…Notably, changes in the lipid composition of the hippocampus and PFC have been consistently associated with cognitive impairment and depressive-like behaviors (Oliveira et al, 2016;Xue et al, 2020;Zhou et al, 2021). On the other hand, the function of several lipids is related to apoptosis and neurogenesis (Huang and Freter, 2015;Knobloch, 2017;Oddi et al, 2020) and the effects of EA on the neurogenesis of hippocampus as well as its neuroprotective effect against neural damage have been largely declared (Kim et al, 2018;Xing et al, 2018;Pei et al, 2021). Therefore, we hypothesized that changes in the lipid composition of the hippocampus and PFC might also be associated with fear and anxietylike behaviors in PTSD.…”

lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway

“…Matusica et al [ 21 ] indicated that BDNF enables P75 (NTR)-derived trophic cell permeapeptides (c29) to promote neuronal survival through the TrkB-dependent signaling pathway in vitro and in vivo. The BDNF/TrkB pathway in learning and memory [ 22 ], chronic pain [ 23 ], and retinopathy [ 24 ] has been deeply studied, but there are few studies on neuronal apoptosis. BDNF-AS is a natural antisense transcript that inhibits the transcription of BDNF [ 15 , 25 ].…”