Electroacupuncture Reduces Rectal Distension-Induced Blood Pressure Changes in Conscious Dogs

Iwa, Masahiro; Strickland, Carmen; Nakade, Yukiomi; Pappas, Theodore N.; Takahashi, Toshio

doi:10.1007/s10620-005-2770-y

Cited by 27 publications

(20 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the analgesic effect of AP has been reported to be mediated by an endogenous opioid pathway (19,48). A previous canine study reported that the painful sensation induced by rectal distension was attenuated by EA at ST-36, and the effect was abolished by pretreatment with naloxone, but not naloxone methiodide, suggesting a central opioid pathway (31). The relationship between the vagal pathway and opioid pathway is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Effects and possible mechanisms of acupuncture at ST36 on upper and lower abdominal symptoms induced by rectal distension in healthy volunteers

Liu

Huang

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Background acupuncture (AP) has been shown to have a therapeutic potential for gastrointestinal motility disorders. The aims of this study were to investigate the effects and possible mechanisms of acupuncture on postprandial upper and lower abdominal symptoms induced by rectal distension (RD). Twenty healthy volunteers were involved in a two-session study (AP and sham-AP, AP and no-AP, or sham-AP and no-AP). In 12 of the volunteers, RD was performed for 60 min in the postprandial state, and AP at ST36 or sham-AP was performed during the second 30-min period of RD. Gastric slow waves and heart rate variability (HRV) were recorded using the electrogastrogram and electrocardiogram, respectively. Upper and lower abdominal symptoms were scored during RD with AP and sham-AP. In five of the subjects, an additional experiment with two sessions (with AP and no-AP) was performed. In the remaining eight volunteers, the same experiment was performed with sham-AP and no-AP was performed. The results were, first, RD at an average volume of 171 ml induced upper and lower abdominal symptoms (P < 0.01). AP, but not sham-AP or no-AP, reduced both upper and lower abdominal symptoms (P < 0.05). Second, RD decreased the percentage of normal gastric slow waves (P < 0.05). AP improved gastric slow waves compared with sham-AP or no-AP (P < 0.05). Third, in the larger, but not smaller, sample size experiment, the vagal activity during the RD plus AP period was significantly higher than that during the RD alone period in the same session and the corresponding period with sham-AP or no-AP in other sessions (P < 0.05). Neither sham-AP nor no-AP showed any effects on vagal activity (P > 0.05). Finally, in the experiment with eight volunteers, neither sham-AP nor no-AP showed any effects on RD-induced impairment in gastric slow waves, abdominal symptoms, or vagal activity (P > 0.05). The conclusions are RD induces upper or lower abdominal symptoms and impairs gastric slow waves in healthy volunteers. AP at ST36 is able to improve upper and lower abdominal symptoms and impaired gastric slow waves induced by RD, possibly mediated via the vagal pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects and possible mechanisms of acupuncture at ST36 on upper and lower abdominal symptoms induced by rectal distension in healthy volunteers

Liu

Huang

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Similar studies were also performed on the RD-induced inhibition in small intestinal motor activity in humans and animals (22,35). More recently, Iwa et al (19) studied the effects of EA on the nociceptive pathway using the RD model. However, little information is available on the effects and mechanisms of RD on gastric contractions.…”

Section: Effects and Mechanisms Of Rd On Gastrointestinal Motilitymentioning

confidence: 99%

“…Also, the mechanism of how RD impairs gastric motility is unclear. It may be mediated via the neural reflex, and either the nociceptive or nonnociceptive afferent pathway is involved, which is correlated with distension volumes and visceral sensation (19). More recent studies showed that sympathovagal balance was altered in IBS patients (23,41,45), but it is not clear whether these activities are altered with RD.…”

mentioning

confidence: 99%

Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs

Chen¹,

Song²,

Yin³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

112

View full text Add to dashboard Cite

puncture improves impaired gastric motility and slow waves induced by rectal distension in dogs. Am J Physiol Gastrointest Liver Physiol 295: G614 -G620, 2008. First published July 24, 2008 doi:10.1152/ajpgi.90322.2008 is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on GSW and motor activity. Eight female hound dogs chronically implanted with gastric serosal electrodes and a gastric fistula were studied in six separate sessions. Antral motility, GSW, heart rate variability, and rectal pressure were evaluated for the above purposes. 1) RD at a volume of 120 ml suppressed antral motility significantly. Guanethidine blocked the inhibitory effect of RD. EA at ST36 was able to restore the suppressed antral contractions induced by RD (16.6 Ϯ 1.7 vs. 8.0 Ϯ 1.4, P Ͻ 0.001). Naloxone partially blocked the effect of EA on antral contractions. 2) RD reduced the percentage of normal GSW from 98.8 Ϯ 0.8% at baseline to 76.1 Ϯ 8.6% (P Ͻ 0.05) that was increased to 91.8 Ϯ 3.0% with EA. The effects of EA on the GSW were nullified by the presence of naloxone. 3) EA did not show any significant effect on rectal pressure, suggesting that the ameliorating effects of EA on RD-induced impaired gastric motility were not due to a decrease in rectal pressure. 4) EA increased the vagal activity suppressed by RD. In conclusion, RD inhibits postprandial gastric motility and impairs GSW in dogs, and the inhibitory effects are mediated via the adrenergic pathways. EA at ST36 is able to restore the RD-induced impaired GSW and motor activities, possibly by enhancing vagal activity, and is partially mediated via the opioid pathway. EA may have therapeutic potential for functional gastrointestinal disorders. adrenergic pathway; gastric slow waves; naloxone CHRONIC, IDIOPATHIC, slow-transit constipation and constipationdominant irritable bowel syndrome (IBS) are commonly observed in clinical practice. These patients frequently complain of upper abdominal symptoms such as bloating, upper abdominal discomfort or pain, and vomiting. The symptoms overlap with lower abdominal symptoms and are resistant to dietary and pharmacological treatments because of the constipation issues; they are related to the presence of impaired gastrointestinal myoelectrical activity and reduced upper gastrointestinal motor activity (1,4,13,31,33,37). This phenomenon has led to the hypothesis that rectal distension (RD) with fecal stasis in the colorectal region directly causes reflexive inhibition of proximal gastrointestinal motility (5,7,9,22,32,50).A number of investigations have indicated that RD induces upper gastrointestinal symptoms, inhibits gastric tone and accommodation, and delays gastric emptying (3, 14, 20 -21, 24, 34 -35, 50). However, little information about the effects of RD on gastric contractions is available, although gastric co...

show abstract

“…These findings suggest that EA at ST-36 may reduce visceral pain via a central opioid pathway. 69 It has been well demonstrated that the analgesic effect of acupuncture is mediated by an endogenous opioid pathway. 32,33 Opioid signaling plays a pervasive role in the medullospinal network that controls sympathetic tone and arterial pressure.…”

Section: Effects Of Acupuncture On Visceral Painmentioning

confidence: 99%

Acupuncture for functional gastrointestinal disorders

2006

Self Cite

View full text Add to dashboard Cite

Functional gastrointestinal (GI) symptoms are common in the general population. Especially, motor dysfunction of the GI tract and visceral hypersensitivity are important. Acupuncture has been used to treat GI symptoms in China for thousands of years. It is conceivable that acupuncture may be effective in patients with functional GI disorders because it has been shown to alter acid secretion, GI motility, and visceral pain. Acupuncture at the lower limbs (ST-36) causes muscle contractions via the somatoparasympathetic pathway, while at the upper abdomen (CV-12) it causes muscle relaxation via the somatosympathetic pathway. In some patients with gastroesophageal reflux disease (GERD) and functional dyspepsia (FD), peristalsis and gastric motility are impaired. The stimulatory effects of acupuncture at ST-36 on GI motility may be beneficial to patients with GERD or FD, as well as to those with constipation-predominant irritable bowel syndrome (IBS), who show delayed colonic transit. In contrast, the inhibitory effects of acupuncture at CV-12 on GI motility may be beneficial to patients with diarrhea-predominant IBS, because enhanced colonic motility and accelerated colonic transit are reported in such patients. Acupuncture at CV-12 may inhibit gastric acid secretion via the somatosympathetic pathway. Thus, acupuncture may be beneficial to GERD patients. The antiemetic effects of acupuncture at PC-6 (wrist) may be beneficial to patients with FD, whereas the antinociceptive effects of acupuncture at PC-6 and ST-36 may be beneficial to patients with visceral hypersensitivity. In the future, it is expected that acupuncture will be used in the treatment of patients with functional GI disorders.

show abstract

Electroacupuncture Reduces Rectal Distension-Induced Blood Pressure Changes in Conscious Dogs

Cited by 27 publications

References 40 publications

Effects and possible mechanisms of acupuncture at ST36 on upper and lower abdominal symptoms induced by rectal distension in healthy volunteers

Effects and possible mechanisms of acupuncture at ST36 on upper and lower abdominal symptoms induced by rectal distension in healthy volunteers

Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs

Acupuncture for functional gastrointestinal disorders

Contact Info

Product

Resources

About