Electroacupuncture Relieves Hippocampal Injury by Heme Oxygenase-1 to Improve Mitochondrial Function

Mu, Rui; Li, Na; Yu, Jianbo; Gong, Lirong; Dong, Shuying; Shi, Jia; Zhang, Yuan; Xie, Zi-lei

doi:10.1016/j.jss.2021.12.013

Cited by 7 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, HO-1 knockout increases ROS and MDA levels and decreases SOD and ATP levels. HO-1 deficiency aggravates mitochondrial swelling, crest relaxation, and vacuole degeneration, indicating the key role of HO-1 in maintaining mitochondrial energy production and resisting oxidative damage in the hippocampus (73). In an SAE rat model, Li et al found that EA DU20, ST36, and LI11 acupoints upregulated the expression of Nrf-2 mRNA and HO-1 protein, increased the SOD level, reduced the MDA level in the hippocampus, reduced the loss of neurons in the hippocampal CA1 area, and increased the 14-day survival rate (75).…”

Section: Brainmentioning

confidence: 99%

Section: Acupuncture Prevents Sepsis Organ Dysfunction By Inhibiting ...mentioning

confidence: 99%

See 1 more Smart Citation

Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review

Yang,

Zhou,

Cao

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Sepsis is a systemic inflammation caused by a maladjusted host response to infection. In severe cases, it can cause multiple organ dysfunction syndrome (MODS) and even endanger life. Acupuncture is widely accepted and applied in the treatment of sepsis, and breakthroughs have been made regarding its mechanism of action in recent years. In this review, we systematically discuss the current clinical applications of acupuncture in the treatment of sepsis and focus on the mechanisms of acupuncture in animal models of systemic inflammation. In clinical research, acupuncture can not only effectively inhibit excessive inflammatory reactions but also improve the immunosuppressive state of patients with sepsis, thus maintaining immune homeostasis. Mechanistically, a change in the acupoint microenvironment is the initial response link for acupuncture to take effect, whereas PROKR2 neurons, high-threshold thin nerve fibres, cannabinoid CB2 receptor (CB2R) activation, and Ca2+ influx are the key material bases. The cholinergic anti-inflammatory pathway of the vagus nervous system, the adrenal dopamine anti-inflammatory pathway, and the sympathetic nervous system are key to the transmission of acupuncture information and the inhibition of systemic inflammation. In MODS, acupuncture protects against septic organ damage by inhibiting excessive inflammatory reactions, resisting oxidative stress, protecting mitochondrial function, and reducing apoptosis and tissue or organ damage.

show abstract

Section: Brainmentioning

confidence: 99%

Section: Acupuncture Prevents Sepsis Organ Dysfunction By Inhibiting ...mentioning

confidence: 99%

Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review

Yang,

Zhou,

Cao

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…In addition, Mu et al [119] first demonstrated that EA at “Zusanli (ST36)” and “Baihui (GV20)” improved LPS-induced hippocampal injury by improving mitochondrial function and that EA treatment reduced neuronal damage in LPS-exposed mice while improving mitochondrial respiratory function, energy metabolism, and mitochondrial morphology. It was also discovered that HO-1 knockdown exacerbated LPS-induced hippocampal injury, decreased mitochondrial respiratory function, increased mitochondrial swelling, cristae relaxation, and vacuolar degeneration and that EA did not reverse the hippocampal injury and mitochondrial dysfunction caused by LPS after HO-1 knockdown.…”

Section: Immunological Basis Of Ea To Alleviate Sepsismentioning

confidence: 99%

Electroacupuncture targeting the immune system to alleviate sepsis

Fang,

Lan,

et al. 2024

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates. However, options for sepsis are still limited to general treatment in intensive care units (ICUs), and effective therapies that improve sepsis survival are required. Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation, susceptibility to infections, and death. Therefore, many investigators have focused on the potential benefits of immunomodulation therapy for sepsis. Electroacupuncture (EA) has been practiced in clinics for many years and has shown advantages in treating infectious diseases. Over the last few decades, our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments. We searched the literature regarding “CNKI, Wan Fang Data, VIP Database, PubMed, and Ingenta Connect” from 2010 to 2023, using the keywords "sepsis," "septic," and “electroacupuncture” and 336 sources were searched. Finally, we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on sepsis. In this review, we found that EA has clinical benefits in relieving septic inflammation, improving immune function, and attenuating related muti-organ injury through several mechanisms, such as activation of the cholinergic anti-inflammatory pathway (CAP), vagal-adrenal axis, inhibition of the nuclear factor Kappa-B (NF-κB) signaling pathway, signal transducers and activators of transcription (STAT) signaling pathway, and improvement of immune cell function. Therefore, EA may be a promising complementary therapy for sepsis treatment. We also expect these data will contribute to further studies on EA in sepsis.

show abstract

Electroacupuncture-modulated extracellular ATP levels in prefrontal cortex ameliorated depressive-like behavior of maternal separation rats

Zheng,

Pan,

et al. 2023

Behavioural Brain Research

View full text Add to dashboard Cite

Electroacupuncture Relieves Hippocampal Injury by Heme Oxygenase-1 to Improve Mitochondrial Function

Cited by 7 publications

References 38 publications

Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review

Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review

Electroacupuncture targeting the immune system to alleviate sepsis

Electroacupuncture-modulated extracellular ATP levels in prefrontal cortex ameliorated depressive-like behavior of maternal separation rats

Contact Info

Product

Resources

About