Electroacupuncture stimulation using different frequencies (10 and 100 Hz) changes the energy metabolism in induced hyperglycemic rats

Figueiredo, Lanese Medeiros de; Silva, Agamenon Honório; Neto, Alberico Ximenes do Prado; Hissa, Miguel Nasser; Vasconcelos, Paulo Roberto Leitão de; Guimarães, Sérgio Botelho

doi:10.1590/s0102-86502011000700010

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…In the field of EA on insulin sensitivity, there are areas such as improvement in glucose tolerance in which EA was able to achieve improved results of insulin sensitivity in basic research and clinical trials [8–14]. Also, some studies showed that different frequencies of EA stimulation (10 and 100 Hz) can change the energy metabolism and lower down plasma glucose levels in induced hyperglycemic rats [15]. So far, there are no review articles to summarize if EA had the frequency-dependent hypoglycemic effect as the effect on pain relief.…”

Section: Introductionmentioning

confidence: 99%

Acupoint‐Specific, Frequency‐Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug‐Combined Therapy Studied by a Randomized Control Clinical Trial

Lin

Tzeng

Lee

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The application of electroacupuncture (EA) to specific acupoints can induce a hypoglycemic effect in streptozotocin-induced rats, normal rats, and rats with steroid-induced insulin resistance. EA combined with the oral insulin sensitizer rosiglitazone improved insulin sensitivity in rats and humans with type II diabetes mellitus (DM). There are different hypoglycemic mechanisms between Zhongwan and Zusanli acupoints by EA stimulation. On low-frequency (2 Hz) stimulation at bilateral Zusanli acupoints, serotonin was involved in the hypoglycemic effect in normal rats. Moreover, after 15 Hz EA stimulation at the bilateral Zusanli acupoints, although enhanced insulin activity mainly acts on the insulin-sensitive target organs, the muscles must be considered. In addition, 15 Hz EA stimulation at the bilateral Zusanli acupoints has the combined effect of enhancing cholinergic nerve activity and increasing nitric oxide synthase (NOS) activity to enhance insulin activity. Despite the well-documented effect of pain control by EA in many systemic diseases, there are few high-quality long-term clinical trials on the hypoglycemic effect of EA in DM. Combination treatment with EA and other medications seems to be an alternative treatment to achieve better therapeutic goals that merit future investigation.

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Section: Introductionmentioning

confidence: 99%

Acupoint‐Specific, Frequency‐Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug‐Combined Therapy Studied by a Randomized Control Clinical Trial

Lin

Tzeng

Lee

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Conversely, restoration of energy metabolism balance in the surrounding cells following acute ischemic stroke may reduce ischemic injury. Studies have demonstrated that EA improves energy metabolism in normal rats (11,12). Therefore, these findings indicate that EA could increase glucose metabolism to protect against neural injury under ischemic stroke.…”

Section: Introductionmentioning

confidence: 66%

Roles of electro-acupuncture in glucose metabolism as assessed by 18F-FDG/PET imaging and AMPKα phosphorylation in rats with ischemic stroke

Lin²,

et al. 2017

International Journal of Molecular Medicine

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Targeted energy metabolism balance contributes to neural survival during ischemic stroke. Herein, we tested the hypothesis that electro‑acupuncture (EA) can enhance cerebral glucose metabolism assessed by 18F‑fluorodeoxyglucose/positron emission tomography (18F‑FDG/PET) imaging to prevent propagation of tissue damage and improve neurological outcome in rats subjected to ischemia and reperfusion injury. Rats underwent middle cerebral artery occlusion (MCAO) and received EA treatment at the LI11 and ST36 acupoints or non‑acupoint treatment once a day for 7 days. After EA treatment, a significant reduction in the infarct volume was determined by T2‑weighted imaging, accompanied by the functional recovery in CatWalk and Rota-rod performance. Moreover, EA promoted higher glucose metabolism in the caudate putamen (CPu), motor cortex (MCTX), somatosensory cortex (SCTX) regions as assessed by animal 18F‑FDG/PET imaging, suggesting that three‑brain regional neural activity was enhanced by EA. In addition, the AMP‑activated protein kinase α (AMPKα) in the CPu, MCTX and SCTX regions was phosphorylated at threonine 172 (Thr172) after ischemic injury; however, phosphorylation of AMPK was further increased by EA. These results indicate that EA could promote AMPKα phosphorylation of the CPu, MCTX and SCTX regions to enhance neural activity and motor functional recovery after ischemic stroke.

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“…In general, the type of responses induced by EA have been known to be frequency dependent. 25–28 However, both studies showed increased parasympathetic activity following EA, which indicates that similar autonomic responses can be induced regardless of EA frequency.…”

Section: Discussionmentioning

confidence: 87%

Influence of electroacupuncture stimulation on skin temperature, skin blood flow, muscle blood volume and pupil diameter

et al. 2019

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Objective: To examine the effect of electroacupuncture (EA) stimulation on multiple physiological indices and to evaluate both local and systemic physiological responses induced by the stimulation. Methods: 15 healthy male college students participated in an experimental crossover study. They received two kinds of interventions: one with EA stimulation and one without EA stimulation on different days. Two disposable acupuncture needles were inserted at two traditional acupuncture points (ST36 and ST38), located along the anterior tibialis muscle. EA stimulation was administered for 10 min. Skin temperature (ST), skin blood flow (SBF) and muscle blood volume (MBV) were recorded near the stimulation sites, while the pupil diameter (PD) was measured before, during and after the interventions. Results: ST, SBF and MBV increased significantly following EA stimulation. PD of the right and left eyes decreased significantly following EA stimulation. There was a significant difference in ST responses between the groups (P=0.001). For SBF, MBV and PD, no significant differences were demonstrated between the groups. Conclusions: Our study showed that 10 min of EA stimulation increased ST, SBF and MBV, and decreased PD, compared to baseline, while no significant change was observed in the control group. This suggests that EA stimulation alters local blood flow and ST, and these responses are likely mediated via segmental spinal reflexes, supraspinal reflexes involving parasympathetic activation, and other mechanisms.

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Electroacupuncture stimulation using different frequencies (10 and 100 Hz) changes the energy metabolism in induced hyperglycemic rats

Cited by 10 publications

References 16 publications

Acupoint‐Specific, Frequency‐Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug‐Combined Therapy Studied by a Randomized Control Clinical Trial

Acupoint‐Specific, Frequency‐Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug‐Combined Therapy Studied by a Randomized Control Clinical Trial

Roles of electro-acupuncture in glucose metabolism as assessed by 18F-FDG/PET imaging and AMPKα phosphorylation in rats with ischemic stroke

Influence of electroacupuncture stimulation on skin temperature, skin blood flow, muscle blood volume and pupil diameter

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