Electroanalysis of neurotransmitters via 3D gold nanoparticles and a graphene composite coupled with a microdialysis device

Zhang, Shu Juan; Kang, Kai; Niu, Ling Mei; Wei, Kang

doi:10.1016/j.jelechem.2018.12.043

Cited by 16 publications

(6 citation statements)

References 65 publications

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“…The most used functionalized structure derived from graphene is graphene oxide (GO). Several graphene-based sensors have been reported for various neurotransmitters measurements in biological samples [26,27,28,29,30,31,32,33,34,35].…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

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Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Tavakolian-Ardakani

Hosu

Cristea

et al. 2019

Sensors

117

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Neurotransmitters are endogenous chemical messengers which play an important role in many of the brain functions, abnormal levels being correlated with physical, psychotic and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Therefore, their sensitive and robust detection is of great clinical significance. Electrochemical methods have been intensively used in the last decades for neurotransmitter detection, outclassing more complicated analytical techniques such as conventional spectrophotometry, chromatography, fluorescence, flow injection, and capillary electrophoresis. In this manuscript, the most successful and promising electrochemical enzyme-free and enzymatic sensors for neurotransmitter detection are reviewed. Focusing on the activity of worldwide researchers mainly during the last ten years (2010–2019), without pretending to be exhaustive, we present an overview of the progress made in sensing strategies during this time. Particular emphasis is placed on nanostructured-based sensors, which show a substantial improvement of the analytical performances. This review also examines the progress made in biosensors for neurotransmitter measurements in vitro, in vivo and ex vivo.

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Section: Electrochemical Sensorsmentioning

confidence: 99%

“…Zhang et al [32] presented a novel biosensor which used a uniform dispersion of GO onto AuNPs to afford DA and 5-HT detection. The biosensor was inserted in electrolytic cell of micro-capacity connected with microdialysis platform.…”

Section: Biosensors For In Vitro In Vivo and Ex Vivo Measurementsmentioning

confidence: 99%

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Tavakolian-Ardakani

Hosu

Cristea

et al. 2019

Sensors

117

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“…They have gained enormous attention for use as a modifier on the surface of electrode owing to their high electronic conductivity and electrocatalytic activity [27,28], as well as other electrochemical applications including energy storage [29,30]. GO has been applied to fabricate the electrochemical sensors for neurotransmitters [31][32][33][34], but it has a problem on spontaneous aggregation. However, the functionalized GO is needed to improve the solubility of GO [35].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Electrochemical Sensor for Dopamine Detection Based on Self-Assembled Mixed Surfactants on Gold Nanoparticles Deposited Graphene Oxide

et al. 2020

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A new supramolecular electrochemical sensor for highly sensitive detection of dopamine (DA) was fabricated based on supramolecular assemblies of mixed two surfactants, tetra-butylammonium bromide (TBABr) and sodium dodecyl sulphate (SDS), on the electrodeposition of gold nanoparticles on graphene oxide modified on glassy carbon electrode (AuNPs/GO/GCE). Self-assembled mixed surfactants (TBABr/SDS) were added into the solution to increase the sensitivity for the detection of DA. All electrodes were characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The supramolecular electrochemical sensor (TBABr/SDS⋅⋅⋅AuNPs/GO/GCE) showed excellent electrocatalytic activity toward the oxidation of DA. Under the optimum conditions, the concentration of DA was obtained in the range from 0.02 µM to 1.00 µM, with a detection limit of 0.01 µM (3s/b). The results displayed that TBABr/SDS⋅⋅⋅AuNPs/GO/GCE exhibited excellent performance, good sensitivity, and reproducibility. In addition, the proposed supramolecular electrochemical sensor was successfully applied to determine DA in human serum samples with satisfactory recoveries (97.26% to 104.21%).

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“…Moreover, they can be suitable for a routine chair-side test represented by a point-of-care testing (POCT) device. Different strategies have been employed to realize the modification of electrode surfaces for improving the selectivity, sensitivity, and accuracy [9,10,11,12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Nanocomposite Single-Use Sensor for Dopamine Detection

Selvolini

Lazzarini

Marrazza

2019

Sensors

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In this work, we report the development of a simple and sensitive sensor based on graphite screen-printed electrodes (GSPEs) modified by a nanocomposite film for dopamine (DA) detection. The sensor was realized by electrodepositing polyaniline (PANI) and gold nanoparticles (AuNPs) onto the graphite working electrode. The sensor surface was fully characterized by means of the cyclic voltammetry (CV) technique using [Fe(CN)6]4−/3− and [Ru(NH3)6]2+/3+ as redox probes. The electrochemical behavior of the nanocomposite sensor towards DA oxidation was assessed by differential pulse voltammetry (DPV) in phosphate buffer saline at physiological pH. The sensor response was found to be linearly related to DA concentration in the range 1–100 μM DA, with a limit of detection of 0.86 μM. The performance of the sensor in terms of reproducibility and selectivity was also studied. Finally, the sensor was successfully applied for a preliminary DA determination in human serum samples.

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Electroanalysis of neurotransmitters via 3D gold nanoparticles and a graphene composite coupled with a microdialysis device

Cited by 16 publications

References 65 publications

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Latest Trends in Electrochemical Sensors for Neurotransmitters: A Review

Supramolecular Electrochemical Sensor for Dopamine Detection Based on Self-Assembled Mixed Surfactants on Gold Nanoparticles Deposited Graphene Oxide

Electrochemical Nanocomposite Single-Use Sensor for Dopamine Detection

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