Electroanalytical and Spectrophotometric Determination of N-acetyl-p-aminophenol in Pharmaceuticals

Abstract

Electrochemical oxidation of N-acetyl-p-aminophenol (AAP) and selected pharmaceutical products containing AAP is described in this study. Investigations were carried out at Pt electrode, with the application of cyclic (CV) and differential pulse (DPV) voltammetry. AAP was irreversibly oxidized in, at least, one electrode step, with potentials lower than the potential at which oxygen evolution started. Electrochemical methods based on voltammetric techniques (DPV and CV) have been developed for AAP determination in commercial pharmaceutical drugs. AAP content in pharmaceuticals was determined on the base of dependences of current intensity (electroanalytical measurements) and absorbance (UV-VIS spectra). The obtained results using both methods were in good agreement. The validation of CV, DPV and spectrophotometric methods is also presented. Spectrophotometric and voltammetric responses linearly increased with increasing AAP concentrations, in the range from 0.2 to 5 mmol L-1 , with a correlation coefficient of 0.997 (UV-VIS), 0.999 (CV) and 0.998 (DPV). Both electrochemical methods are simple, reliable and sufficiently accurate and precise for AAP quantification in commercial drug samples (tablets). The analysis took only 5 minutes of manual operation, including Pt electrode pre-treatment.

Emerging trends in the development and applications of triazine-based covalent organic polymers: a comprehensive review

“…Hence, nitroaromatic compounds are reduced to their amino counterparts as they have many uses in pharmaceuticals, dyestuffs and agrochemical products. 140 In 2019, Fan et al 141 developed two noble-metal-cluster-based triazinyl polymers, COF-Ph and COF-BPh, via a nucleophilic substitution reaction of cyanuric chloride with p -phenylenediamine and 4,4-diaminobiphenyl, respectively. Afterwards, Pd clusters were immobilized on the surface via a double solvent approach in order to control the size of the metal clusters.…”

Recent advances in the design, synthesis and catalytic applications of triazine-based covalent organic polymers

“…139 Nitroarenes are the main pollutant present in industrial waste water along with other environmental pollutants, which are extremely lethal, stable and non-biodegradable, 140 whereas amino derivatives in comparison with these, are useful in pharmaceuticals, anticorrosion, dyestuffs, and agrochemical applications. 141 Mengying et al (2019) synthesized two triazine-based polymeric materials, COF-Ph and COF-BPh, by simple nucleophilic substitution of 2,4,6-trichloro-1,3,5-triazine and p-phenylenediamine and 4,4 0 -diaminobiphenyl, respectively (Fig. 17a).…”

“…139 Nitroarenes are the main pollutant present in industrial waste water along with other environmental pollutants, which are extremely lethal, stable and non-biodegradable, 140 whereas amino derivatives in comparison with these, are useful in pharmaceuticals, anticorrosion, dyestuffs, and agrochemical applications. 141…”

The preparation of AuNPs/B-dNACNs and their application in P-aminophenol electrochemical sensing

“…4 Hence, it is very important to strictly control the excessive residual 4-AP in the environment 5 and accurately determine the presence of 4-AP in drugs. 6 To date, various methods such as fluorescence spectrophotometry, 7,8 UV spectroscopy, 9 gas chromatography 10 and liquid chromatography 11 have been utilized to detect 4-AP. In comparison to these techniques, the electrochemical method has gained increasing attention due to its low cost, convenience, superior selectivity, and sensitivity.…”