Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms

Abstract

Non-steroidal antienflamatuvar ilaç etken maddesi tenoksikamın (TX) elektro-oksidasyon davranışı çok duvarlı karbon nanotüple (MWCNT) modifiye edilmiş camsı karbon elektrot (GCE) ile dönüşümlü voltametri, diferansiyel puls voltametri (DPV) ve kare dalga voltametri (SWV) ile çalışılmıştır. Gereç ve Yöntemler: GCE, TX'in voltametrik metodlarla hassas tayini için MWCNT ile modifiye edilmiştir. Bulgular: Potansiyel pozitif yönde tarandığında TX'in pik akımı 0.520 V civarında DPV ile, 0.570 V civarında SWV ile oluşmuştur. TX'in oksidasyon prosesi tersinmez ve diffüzyon kontrollü davranış göstermiştir. DPV ve SWV için doğrusal cevaplar sırasıyla 2×10-7-1×10-5 M, 1.43×10-9 M yakalama alt sınırı (LOD) ile, 8×10-9-8×10-6 M, 9.97×10-10 M LOD ile 1 M asetat tamponu pH 5.5 içinde elde edilmiştir. Sonuç: Tamamen valide edilmiş DPV ve SWV başarılı bir şekilde TX'in farmasötik dozaj formundan miktar tayini için uygulanmış ve memnun edici sonuçlar elde edilmiştir.

تقنية كرموتوغرافيا السائل ذات الاداء العالي ذوالطور العكسي مع كاشف الاشعة الفوق البنفسجية لتقدير ادوية الايبو بروفين والتنوكسيكام في الصورة النقية و الاقراص الدوائية

“…TNX obstructs the actions of COX enzymes, the chemicals responsible for pain and inflammation. Various techniques have been employed to determine the levels of TNX, including HPLC 15 , UV 16 , fluorescence 17 , flow injection 18 , and ionpair 19 spectrophotometry, electro analytical 20 , voltammetry 21 , X-ray 22 , scanning electron microscopy (SEM), X-ray diffraction, dynamic light scattering (DLS), Fourier transform infrared (FTIR) 23 , photo catalysis 24 , and immunochromatographic strip with colloidal gold 25 .…”

Eco-Friendly High-Performance Thin-Layer Chromatography Method for the Determination of Tenoxicam in Commercial Formulations

“…For the purpose of determining TNX in pharmaceutical formulations, a few high-performance thin-layer chromatography (HPTLC) methods were also published. ,, An HPTLC method has also been reported to determine TNX in combination with piroxicam, celecoxib, and rofecoxib in the whole human blood and urine . Some voltammetry techniques were also used to detect TNX in dosage forms. , Some other approaches such as potentiometric, polarographic, indirect flow-injection spectrophotometry, reverse flow-injection method, fluorescence probe, colloidal gold strip sensor, and quantum dots as fluorescence probe have also been utilized to determine TNX, either alone or in combination with other NSAIDs in pharmaceutical preparations.…”

“… 27 Some voltammetry techniques were also used to detect TNX in dosage forms. 28 , 29 Some other approaches such as potentiometric, 30 polarographic, 31 indirect flow-injection spectrophotometry, 32 reverse flow-injection method, 33 fluorescence probe, 34 colloidal gold strip sensor, 35 and quantum dots as fluorescence probe 36 have also been utilized to determine TNX, either alone or in combination with other NSAIDs in pharmaceutical preparations.…”