Electroanalytical methods for determination of antiviral drugs in pharmaceutical formulation and biological fluids: A review

Aydoğmuş, Zeynep; Asfoor, Adel

doi:10.1016/j.cjac.2022.100063

Cited by 13 publications

(3 citation statements)

References 128 publications

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“…As a means to better understand the pharmacokinetic profile of drugs/nanoparticles while providing accessible devices to scientists and patients to quantify different compounds from simple/complex matrices rapidly and in an easy manner, the electrochemical analysis contributes to this field with a wide variety of sensors compatible with portable devices, i.e., mobile phones, with applications in research, industry or even medical units [ 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

et al. 2022

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The present study aimed to optimize a liposomal formulation co-encapsulating simvastatin (SIM) and doxorubicin (DOX) that has future perspectives in anticancer therapy. The optimization process was performed by implementing the Quality by Design concept and by considering the results of a previous screening study. Failure Mode and Effects Analysis was used for the identification of the potential critical factors, i.e., phospholipid, SIM and DOX concentration, which were assessed in an optimization experimental design with the purpose of designing an optimal formulation. The optimal formulation, meeting the established quality profile, was additionally characterized in terms of the release profile and antiproliferative effects. During dissolution studies, a novel chronoamperometric method was used for the simultaneous quantification of SIM and DOX. The obtained data confirmed the similarity of this method with a validated HPLC method. The anticancer potential of the optimal formulation was tested against two human cancerous cell lines, namely T47D-KBluc human mammary ductal carcinoma cell line and A549 human pulmonary cancer cell line. The results highlighted that the antiproliferative effect of the optimal formulation is concentration dependent and favors a synergistic effect of the two drugs.

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Section: Resultsmentioning

confidence: 99%

The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

et al. 2022

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“…Unfortunately, no specific drugs were available for the treatment of such a disease. However, patients diagnosed with Covid‐19 were prescribed several antiviral drugs with proven effectiveness and safety against viruses [1–4] . Favipiravir (FAV) exhibited an effective activity against influenza virus and was prescribed with paracetamol for the treatment of Covid‐19 [1] .…”

Section: Introductionmentioning

confidence: 99%

Construction of a Voltammetric Sensor Based on Niobium Supported on Zirconium Oxide‐Carbon Nanotubes for the Determination of Favipiravir, an Antiviral Drug Used Against Covid‐19

Kutluay Baytak,

Aslanoglu

2024

ChemistrySelect

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This study aims to develop of a novel electrochemical method for the detection of the antiviral drug favipiravir (FAV). For this purpose, a sensitive electrochemical sensor with niobium (Nb) nanoparticles supported on zirconium oxide‐carbon nanotubes (ZrO2‐(CNT)MW) was constructed on a glassy carbon electrode (GCE). The proposed electrochemical sensor (Nb@ZrO2‐(CNT)MW/GCE) exhibited excellent repeatability, high stability and high sensitivity for FAV owing to the impact of Nb on ZrO2‐(CNT)MW composite. The oxidation potential (Ep) of FAV was occurred at 1.2 V, 1.12 V, 1.03 V and 1 V at GCE, (CNT)MW/GCE, ZrO2‐(CNT)MW/GCE and Nb@ZrO2‐(CNT)MW/GCE, respectively. Interestlingly, the gradual shift clearly indicates that Nb@ZrO2‐(CNT)MW/GCE can exhibit high catalytic activity towards FAV. The proposed electrode has also good selectivity towards FAV. The Nb@ZrO2‐(CNT)MW/GCE system exhibited a linear working range of 5 nM–300 nM with a limit of detection (LOD) of 1.8 nM (based on 3sb/m) for FAV. The Nb@ZrO2‐(CNT)MW/GCE system was successfully applied for the detection of FAV in pharmaceuticals and biological fluids. The experimental results demonstrated that Nb@ZrO2‐(CNT)MW/GCE can be an ideal sensing platform for the sensitive detection of FAV.

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“…However, despite the advantages of these instrumental methods, in recent years, research has focused on applying electrochemical methods for the determination of statins in both pharmaceuticals and biological Considering the frequent use and variety of pharmaceutical products containing statins and other substances with therapeutic activities, such as acetylsalicylic acid, ramipril, enalapril, metoprolol, amlodipine, hydrochlorothiazide, atenolol, ezetimibe, etc., their quality control would not be possible without reliable analytics methods. Therefore, it is necessary to quantify the biologically active compounds in these pharmaceutical products via fast and accurate methods [9,10].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Statins in Pharmaceutical Products Using Screen-Printed Sensors Based of Multi-Walled Carbon Nanotubes and Gold Nanoparticles

Roșca,

Bounegru,

Apetrei

2023

Inventions

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This study describes the use of electrochemical sensors to detect and quantify several statins (rosuvastatin and simvastatin) in pharmaceutical products. Two types of commercially screen-printed sensors were used and compared: one based on carbon (SPCE) and the other modified with gold nanoparticles and multi-walled carbon nanotubes (SPE/GNP-MWCNT). Cyclic voltammetry was employed for determination. The AuNP-MWCNTs/SPCE sensor outperformed the SPCE sensor, displaying excellent electrochemical properties. It demonstrated high sensitivity with low limits of detection (LOD) and quantification (LOQ) values: 0.15 µM and 5.03 µM, respectively, for rosuvastatin and 0.30 µM and 1.01 µM, respectively, for simvastatin. The sensor had a wide linear range of 20–275 µM for rosuvastatin and 50–350 µM for simvastatin. Using the AuNP-MWCNTs/SPCE sensor, rosuvastatin and simvastatin were successfully quantified in pharmaceutical products. The results were validated towards producer-reported values (standardized drugs) and a conventional analysis method (FTIR). The sensor exhibited excellent stability, reproducibility, and analytical recovery ranging from 99.3% to 106.6% with a low relative standard deviation (RSD) of less than 1%. In conclusion, the AuNP-MWCNTs/SPCE sensor proved to be a reliable and sensitive tool for detecting and quantifying statins in pharmaceutical products. Its superior electrochemical properties, low LOD and LOQ values, wide linear range, and high analytical recovery make it a promising choice for pharmaceutical quality control.

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Electroanalytical methods for determination of antiviral drugs in pharmaceutical formulation and biological fluids: A review

Cited by 13 publications

References 128 publications

The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

The Use of the QbD Approach to Optimize the Co-Loading of Simvastatin and Doxorubicin in Liposomes for a Synergistic Anticancer Effect

Construction of a Voltammetric Sensor Based on Niobium Supported on Zirconium Oxide‐Carbon Nanotubes for the Determination of Favipiravir, an Antiviral Drug Used Against Covid‐19

Quantification of Statins in Pharmaceutical Products Using Screen-Printed Sensors Based of Multi-Walled Carbon Nanotubes and Gold Nanoparticles

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