Electroanalytical paper-based device for reliable detection and quantification of sugars in milk

Dortez, Silvia; Crevillen, Agustín G.; Escarpa, Alberto; Cinti, Stefano

doi:10.1016/j.snb.2023.134704

Cited by 12 publications

(5 citation statements)

References 41 publications

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“…Office paper is a valuable substrate for producing electrochemical sensors and biosensors, as reported in the literature. − As the starting point, the quality and the ability of our handmade printed strips to recognize nitrites were tested through the use of cyclic voltammetry (CV) in the presence of increasing concentrations of the target, using a phosphate buffer, pH = 7, as the working solution. As displayed in Figure A, a clear oxidation peak is visible at around 0.9 V that can be ascribed to the electro-oxidation of nitrite (NO 2 – ) to nitrate (NO 3 – ), as shown in following equation: NO 2 – + H 2 O → NO 3 – + 2H + + 2e –…”

Section: Resultsmentioning

confidence: 99%

“…However, the development of novel and more sustainable portable devices for the use of nonspecialists represents a leitmotiv in the field of measurement science. In particular, the field of electrochemical-based sensors and biosensors is being characterized by the implementation of novel methods that are based on the use of paper-based substrates. , Paper is becoming increasingly common among materials for the production of POC devices due to its many advantages including sustainability, portability, low production cost, ease of use, and the possibility of customization and modification . However, the different paper-based substrates are characterized by diverse properties, such as thickness and pore size.…”

Section: Introductionmentioning

confidence: 99%

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Technical Evaluation of a Paper-Based Electrochemical Strip to Measure Nitrite Ions in the Forensic Field

Raucci,

Miglione,

Cimmino

et al. 2023

ACS Meas. Sci. Au

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Nitrite is a compound used as a food additive for its preservative action and coloring capability, as well as an industrial agent for its antifreezing action and for preventing corrosion, and it is also used as a pharmaceutical in cyanide detoxification therapy. However, even recently, because of its high toxicity, it has been used as a murder and suicidal agent due to its affordability and ready availability. In this technical report, we describe an electrochemical paper-based device for selectively determining nitrite in complex biofluids, such as blood, cadaveric blood, vitreous humor, serum, plasma, and urine. The approach was validated in terms of the linearity of response, selectivity, and sensitivity, and the accuracy of the determination was verified by comparing the results with a chromatographic instrumental method. A linear response was observed in the micromolar range; the sensitivity of the method expressed as the limit of detection was 0.4 μM in buffer measurements. The simplicity of use, the portability of the device, and the performance shown make the approach suitable for detecting nitrite in complex biofluids, including contexts of forensic interest, such as murders or suicides in which nitrite is used as a toxic agent. Limits of detection of ca. 1, 2, 4, 5, 3, and 4 μM were obtained in vitreous humor, urine, serum and plasma, blood, and cadaveric blood, also highlighting a satisfactory accuracy comprised between 91 and 112%.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Technical Evaluation of a Paper-Based Electrochemical Strip to Measure Nitrite Ions in the Forensic Field

Raucci,

Miglione,

Cimmino

et al. 2023

ACS Meas. Sci. Au

Self Cite

View full text Add to dashboard Cite

show abstract

“…Paper-based assays can be tailored to identify specific adulterants through selective reactions, quickly assessing food purity. Recent examples include the detection of adulteration in Iranian honey [ 243 ] and milk adulteration with melamine [ 244 ], starch [ 245 ], sugar [ 246 ], and urea [ 247 ]. Wu et al [ 248 ] developed a surface molecularly imprinted microfluidic paper-based device (SMIPs-

PAD) for detecting butachlor in mung bean samples.…”

Section: Food Safetymentioning

confidence: 99%

Sustainable Sensing with Paper Microfluidics: Applications in Health, Environment, and Food Safety

Kumar,

Kaushal,

Lee

2024

Biosensors

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This manuscript offers a concise overview of paper microfluidics, emphasizing its sustainable sensing applications in healthcare, environmental monitoring, and food safety. Researchers have developed innovative sensing platforms for detecting pathogens, pollutants, and contaminants by leveraging the paper’s unique properties, such as biodegradability and affordability. These portable, low-cost sensors facilitate rapid diagnostics and on-site analysis, making them invaluable tools for resource-limited settings. This review discusses the fabrication techniques, principles, and applications of paper microfluidics, showcasing its potential to address pressing challenges and enhance human health and environmental sustainability.

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“…Paper-based assays can be tailored to identify specific adulterants through selective reactions, quickly assessing food purity. Recent examples include the detection of adulteration in Iranian honey [232], milk adulteration with melamine [233], starch [234], sugar [235], and urea [236]. Wu et al [237] developed a surface molecularly imprinted microfluidic paper-based device (SMIPs-µPAD) for detecting butachlor in mung bean samples.…”

Section: Food Safetymentioning

confidence: 99%

Sustainable Sensing with Paper Microfluidics: Applications in Health, Environment, and Food Safety

Kumar,

Kaushal,

Lee

2024

Preprint

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This manuscript offers a concise overview of paper microfluidics, emphasizing its sustainable sensing applications in healthcare, environmental monitoring, and food safety. Researchers have developed innovative sensing platforms for detecting pathogens, pollutants, and contaminants by leveraging the paper’s unique properties, such as biodegradability and affordability. These portable, low-cost sensors facilitate rapid diagnostics and on-site analysis, making them invaluable tools for resource-limited settings. The review discusses fabrication techniques, principles, and applications of paper microfluidics, showcasing its potential to address pressing challenges and enhance human health and environmental sustainability.

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Electroanalytical paper-based device for reliable detection and quantification of sugars in milk

Cited by 12 publications

References 41 publications

Technical Evaluation of a Paper-Based Electrochemical Strip to Measure Nitrite Ions in the Forensic Field

Technical Evaluation of a Paper-Based Electrochemical Strip to Measure Nitrite Ions in the Forensic Field

Sustainable Sensing with Paper Microfluidics: Applications in Health, Environment, and Food Safety

Sustainable Sensing with Paper Microfluidics: Applications in Health, Environment, and Food Safety

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