Electroanalytical Sensors and Methods for Assays and Studies of Neurological Biomarkers

Chen, Shu; Zhang, Lin; Long, Yunfei; Zhou, Feimeng

doi:10.1002/elan.201400040

Cited by 9 publications

(3 citation statements)

References 144 publications

(146 reference statements)

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“…A more indepth survey of non-peptide or -protein biomarkers related to neurological disorders is provided in another review paper by our group. 80…”

Section: Biomarkers Related To Neurological Disordersmentioning

confidence: 99%

Electroanalytical and surface plasmon resonance sensors for detection of breast cancer and Alzheimer's disease biomarkers in cells and body fluids

Yang

Wang

et al. 2014

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Cancer and neurological disorders are two leading causes of human death. Their early diagnoses will either greatly improve the survival rate or facilitate effective treatments or modalities. Detection of biomarkers in body fluids and some tissues (e.g., blood, urine and cerebrospinal fluids) is relatively non-invasive and provides useful chemical and biological information that is complementary to tomographic imaging (e.g., magnetic resonance imaging, positron emission tomography and X-ray computed tomography). Recent years have witnessed the contributions from and potential applications of bioanalytical methods for early detection of major diseases. In this review, we survey some recent developments of electroanalytical (as a representative label-based technique) and surface plasmon resonance (SPR) (as a representative label-free technique) biosensors for detection of biomarkers relevant to etiologies of breast cancer and Alzheimer's disease (AD). While breast cancer is representative of cancers of complexity (multiple biomarkers, false positives from tomographic scans, and a need for more effective early diagnostic methods), AD is the most prevalent neurological disorder that is also linked to multiple biomarkers. Both electroanalytical and SPR-based sensors have attractive features of sensitivity, portability, obviation of large sample volumes, and capability of multiplexed detection. Various sensing protocols developed in the past five years are reviewed, demonstrating the feasibility of both techniques for diagnostic purposes. Problems inherent in these two techniques that must be overcome before being clinically viable are also discussed.

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“…A more indepth survey of non-peptide or -protein biomarkers related to neurological disorders is provided in another review paper by our group. 80…”

Section: Biomarkers Related To Neurological Disordersmentioning

confidence: 99%

Electroanalytical and surface plasmon resonance sensors for detection of breast cancer and Alzheimer's disease biomarkers in cells and body fluids

Yang

Wang

et al. 2014

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“…According to a projection of the World Health Organization, neurological disorders and diseases are one of the principal causes of disability and death worldwide, including Parkinson's, Alzheimer's, Creutzfeldt-Jakob, Huntington's, and Wilson's diseases [1,2]. In particular, Parkinson's disease (PD) is the second leading cause of the neurodegenerative disorder, which affects about 1 and 4% of the people above the ages of 60 and 80 years old, respectively [3].…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Immunosensor Based on a Self-Assembled Monolayer Modified Electrode for Label-Free Detection of α-Synuclein

Rahman

Zhang

et al. 2020

Sensors

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This research demonstrated the development of a simple, cost-effective, and label-free immunosensor for the detection of α-synuclein (α-Syn) based on a cystamine (CYS) self-assembled monolayer (SAM) decorated fluorine-doped tin oxide (FTO) electrode. CYS-SAM was formed onto the FTO electrode by the adsorption of CYS molecules through the head sulfur groups. The free amine (–NH2) groups at the tail of the CYS-SAM enabled the immobilization of anti-α-Syn-antibody, which concurrently allowed the formation of immunocomplex by covalent bonding with α-Syn-antigen. The variation of the concentrations of the attached α-Syn at the immunosensor probe induced the alternation of the current and the charge transfer resistance (Rct) for the redox response of [Fe(CN)6]3−/4−, which displayed a linear dynamic range from 10 to 1000 ng/mL with a low detection limit (S/N = 3) of ca. 3.62 and 1.13 ng/mL in differential pulse voltammetry (DPV) and electrochemical impedance spectra (EIS) measurements, respectively. The immunosensor displayed good reproducibility, anti-interference ability, and good recoveries of α-Syn detection in diluted human serum samples. The proposed immunosensor is a promising platform to detect α-Syn for the early diagnose of Parkinson’s disease, which can be extended for the determination of other biologically important biomarkers.

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“…Miniaturized sensing applications frequently rely on electrochemical detection methods due to the relative simplicity of their miniaturization and integration with microfluidic components . The limiting factor to how small an electrochemical sensor can be made is often determined by the magnitude of its signal response which diminishes with the loss of surface area inherent in miniaturization.…”

Section: Introductionmentioning

confidence: 99%

An Improved Design and Versatile New Lamination Fabrication Method for Twin Electrode Thin Layer Cells Utilizing Track‐etch Membranes

Hauke

Ehrlich²,

Levine³

et al. 2018

Electroanalysis

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Reported here are laminated membrane electrodes, an improved design and more advantageous method of fabrication for previously reported thin layer cell electrode systems developed on track‐etch membranes. The laminated membrane approach potentially further improves flow resistance by dramatically reducing the surface area to volume ratio, but also produces a cohesive device that can be more readily applied to a broad range of applications. In addition, this new fabrication method was implemented in a scalable, commercial process and resulting product demonstrations indicate that volume manufacturing is feasible. Characterization of laminated membrane electrodes reveal redox cycling amplification factors as high as 30 with linear responses to variable concentrations of redox couple. These performance characteristics are shown to be comparable to similar generator‐collector systems fabricated through much more laborious laboratory methods. This combination of added versatility, cost‐reduced fabrication and exceptional performance clearly reveals unrealized potential of track‐etch membrane approaches and boosts their candidacy as powerful new options for generator‐collector electrode systems.

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Electroanalytical Sensors and Methods for Assays and Studies of Neurological Biomarkers

Cited by 9 publications

References 144 publications

Electroanalytical and surface plasmon resonance sensors for detection of breast cancer and Alzheimer's disease biomarkers in cells and body fluids

Electroanalytical and surface plasmon resonance sensors for detection of breast cancer and Alzheimer's disease biomarkers in cells and body fluids

An Electrochemical Immunosensor Based on a Self-Assembled Monolayer Modified Electrode for Label-Free Detection of α-Synuclein

An Improved Design and Versatile New Lamination Fabrication Method for Twin Electrode Thin Layer Cells Utilizing Track‐etch Membranes

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