Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults

Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats

“…We investigated ECG alterations because it was found that the severity of changes in ECG is directly related to the known DOX-induced cardiotoxicity in humans and animals. 41,42 Our results clearly indicate that DOX resulted in myocardial injury as indicated by the increase in the RR interval and QA and the decrease in HR of the ECG records. It has been documented that these ECG changes are associated with the prolongation of action potential duration and DOX could strongly affect the recovery phase of the transmembrane action potential, influencing preferentially Ca 2+ movements across the cellular membrane.…”

Ventricular Repolarization Intervals in Children Previously Treated with Anthracyclines

“…Back in 1992 researchers [11] discovered that the use of anthracycline in patients could cause QTc prolongation, increased supraventricular, and ventricular tachycardia compared to normal controls (P<0.001). Contrary to our study these researchers found no significant difference between the case and the control group regarding QT dispersion and QTc dispersion (p>0.05).…”

Radiation Therapy Induced Cardiovascular Disease

“…Furthermore, it has been shown that irradiated arteries demonstrate endothelial dysfunction evidenced by impaired flow-mediated dilation, suggestive of impaired endothelial nitric oxide release, which may predispose to atherosclerosis and cardiovascular events (8). The generalized fibrotic change affects all regions of cardiac tissue, with fibrosis and often calcification of the cardiac valve cusps and/or leaflets, the myocardium and conducting system as well as dense collagen and fibrin replacement of the pericardial fat leading to pericardial fibrosis and effusions (1,(9)(10)(11)(12).…”