Electrocardiographic Changes and Tissue Catecholamines in Experimental Subarachnoid Haemorrhage

Offerhaus, L; Gool, J. van

doi:10.1093/cvr/3.4.433

Cited by 71 publications

(25 citation statements)

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“…[15][16][17][18] In many of the former models, SAH was induced by injection of autologous blood into the subarachnoid space. 17,18 However, these models do not reflect the true pathophysiological features of aneurysmal SAH because the elevation of ICP occurs early after the injection of autologous blood, and this unnecessarily affects cardiohemodynamic functions.…”

Section: Discussionmentioning

confidence: 99%

Sympathetic Nervous Activity and Myocardial Damage Immediately After Subarachnoid Hemorrhage in a Unique Animal Model

Masuda

Sato

Yamamoto

et al. 2002

Stroke

176

117

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Background and Purpose-Obvious cardiac dysfunction, including ECG abnormalities and left ventricular asynergy, is known to develop after subarachnoid hemorrhage (SAH). To clarify the close relationship between myocardial damage and sympathetic nervous activity immediately after SAH, a novel experimental animal model was used. Methods-SAH was provoked by perforation of the basilar artery with the use of a microcatheter inserted through the femoral artery in 18 beagle dogs. Hemodynamic changes were recorded, and plasma concentrations of noradrenaline, adrenaline, and 3-methoxy-4-hydroxy-phenylethylene glycol (MHPG) and serum levels of creatine kinase-MB (CK-MB) and troponin T were measured at 0, 5, 15, 30, 60, 120, and 180 minutes after SAH. Results-Noradrenaline (pg/mL), adrenaline (pg/mL), and MHPG (ng/mL) increased abruptly from 120Ϯ70, 130Ϯ70, and 1.3Ϯ0.5 before SAH to 1700Ϯ1200, 5600Ϯ3500, and 3.2Ϯ1.2 at 5 minutes after SAH, respectively. Aortic pressure, left ventricular wall motion, and cardiac output increased by 60%, 40%, and 30%, respectively (PϽ0.001) at 5 minutes and then decreased by 50%, 55%, and 40%, respectively (PϽ0.001) Ͼ60 minutes after SAH compared with baseline values. The peak value of CK-MB correlated positively with the peak values of noradrenaline and adrenaline (rϭ0.730 and rϭ0.611, respectively). The peak value of troponin T also correlated positively with the peak values of noradrenaline and adrenaline (rϭ0.828 and rϭ0.792, respectively). Conclusions-These results suggest that the elevated activity of the sympathetic nervous system observed in the acute phase of SAH induced myocardial damage and contributed to the development of cardiac dysfunction.

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Section: Discussionmentioning

confidence: 99%

Sympathetic Nervous Activity and Myocardial Damage Immediately After Subarachnoid Hemorrhage in a Unique Animal Model

Masuda

Sato

Yamamoto

et al. 2002

Stroke

176

117

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“…Megyesi et al (8) reported that 28% of CVS animal models were created using endovascular puncture or vascular laceration, and 72% by injecting blood into the subarachnoid space or inserting a blood clot in vessels to induce convulsion. However, there are various limitations to these SAH animal models.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, there are numerous differences in vascular anatomy between mice and humans. Cerebral ischemia and spasm do not usually appear throughout the rich collateral circulation in such a short time window (8,9). Therefore, a novel animal model for SAH is required.…”

Section: Discussionmentioning

confidence: 99%

Platelet-derived growth factor-β expression in rabbit models of cerebral vasospasm following subarachnoid hemorrhage

Cui

Yan

Ding

et al. 2014

Molecular Medicine Reports

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Abstract. Subarachnoid hemorrhage (SAH), one of the serious types of stroke incurred by bleeding into the space surrounding the brain, occurs when brains are deprived of oxygen by various factors, particularly an interruption to the blood supply or a ruptured aneurysm. Cerebral vasospasm (CVS) is one of the most common complications of SAH. It has been proposed that platelet-derived growth factor (PDGF) is involved in CVS. The aim of the present study was to analyze expression of PDGF in rabbit models of CVS. Post-SAH CVS rabbit models were created using endovascular puncture and employed to analyze the expression patterns of PDGF by enzyme-linked immunosorbent assay and immunohistochemistry. The results indicated that the creation of the rabbit model of CVS induced using endovascular puncture was successful and demonstrated the double phase changes observed in human CVS. The acute stage started at 12 h post-SAH with narrowing of the vascular lumen diameter. This narrowing appeared again on the seventh day in delayed CVS alongside increased thickness of vessel walls. PDGF-β expression was observed in vascular smooth muscle cells of the rabbit models. PDGF-β was expressed as early as 3 h post-SAH, it was evident after 1 day and reached a peak in 7 days, suggesting that PDGF-β is involved in the early stages of CVS. In the current study, it was confirmed that PDGF-β expression was present in the rabbit models of CVS, which may aid the elucidation of the pathogenesis of CVS, and also provide useful information for diagnosis and treatment of CVS.

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“…In order to simulate a subarachnoid hemorrhage (SAH) in laboratory animals, the techniques employed have introduced blood in the subarachnoid space over the parietal (Hawkins and Clower, 1971) parieto-occipital (Estanol et al, 1977), occipital (Offerhaus and Van Gool, 1969) regions and in the cisterna magna (Pickard and Perry, 1984;Uemura et al, 1986). Radio opaque catheters have also been used (Estanol et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

A non-traumatic approach to ventral subarachnoid space near circle of willis

Lacy

1988

Journal of Neuroscience Methods

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A non-traumatic approach to the subarachnoid space near the circle of Willis is demonstrated in this study. The approach is made between the olfactory bulb and frontal lobe. Following perfusion with Evans blue dye no leakage was observed into the parenchyma indicating no tissue damage had occurred. No gross bleeding or cerebral vasospasm was visible in the middle meningeal artery (dural), the surface pial blood vessels and the vessels of the circle of Willis. In conclusion, this technique can be successfully used for studies on experimental subarachnoid hemorrhage simulated on the ventral aspect of the brain near the circle of Willis without causing technique-associated cerebrovascular and parenchymal injury.

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Electrocardiographic Changes and Tissue Catecholamines in Experimental Subarachnoid Haemorrhage

Cited by 71 publications

References 0 publications

Sympathetic Nervous Activity and Myocardial Damage Immediately After Subarachnoid Hemorrhage in a Unique Animal Model

Sympathetic Nervous Activity and Myocardial Damage Immediately After Subarachnoid Hemorrhage in a Unique Animal Model

Platelet-derived growth factor-β expression in rabbit models of cerebral vasospasm following subarachnoid hemorrhage

A non-traumatic approach to ventral subarachnoid space near circle of willis

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