Electrocardiographic criteria for vagotonia—validation with pharmacological parasympathetic blockade in healthy subjects

Lazzoli, José Kawazoe; Soares, Pedro Paulo da Silva; Nóbrega, Antônio Cláudio Lucas da; Araújo, Cláudio Gil Soares de

doi:10.1016/s0167-5273(02)00330-3

Cited by 29 publications

(22 citation statements)

References 28 publications

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“…This aspect is clinically interesting, as previous studies with the latter protocol have demonstrated that the rapid movement of the legs or arms 39 and even the bending of wrists 40 is capable of inducing a rapid and sharp increase in heart rate and also the SBP 41 and that this response can be completely abolished by selective pharmacological blockade with atropine 42 , characterizing the mechanism of vagal inactivation as responsible for the response.…”

Section: Discussionmentioning

confidence: 91%

Respostas hemodinâmicas a um protocolo de treinamento isométrico de preensão manual

Araújo¹,

Duarte

Gonçalves

et al. 2011

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 91%

Respostas hemodinâmicas a um protocolo de treinamento isométrico de preensão manual

Araújo¹,

Duarte

Gonçalves

et al. 2011

Arq. Bras. Cardiol.

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“…The 4sET is based on the physiological concept of vagal withdrawal predominating the Wrst 4-6 s of exercise initiation and has been validated using pharmacological intervention (Araujo et al 1992;Lazzoli et al 2003;Nobrega and Araujo 1993). This concept is similar to that utilized during deep breathing or Valsalva maneuver autonomic tests (Braune et al 1996).…”

Section: Nonlinear Measures Of Hr Dynamicsmentioning

confidence: 99%

Isometric handgrip exercise improves acute neurocardiac regulation

et al. 2009

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Isometric handgrip (IHG) training (>6 weeks) has been shown to reduce resting arterial blood pressure (ABP) and improve cardiac autonomic modulation. However, the effects of a single bout of IHG on acute neurocardiac regulation remain unknown. The purpose of this study was to examine the effect of IHG exercise on nonlinear heart rate dynamics and cardiac vagal activity. Nonlinear dynamics were assessed by sample entropy, detrended fluctuation analysis (alpha(1)), and correlation dimension techniques. The 4-second exercise test was used to calculate the cardiac vagal index (CVI), an indirect measure of cardiac vagal activity. In a randomized crossover design, 18 older (70 +/- 5 years of age) subjects completed IHG exercise (four 2-min isometric contractions at 30% MVC) and a time-matched control condition. Following a single bout of bilateral IHG, there was a small reduction in systolic blood pressure (125 +/- 2 to 122 +/- 1 mmHg, P < 0.01), in addition to, a significant decrease in alpha(1) (1.42 +/- 0.12 to 1.22 +/- 0.10, P < 0.05), an increase in sample entropy (1.28 +/- 0.03 to 1.40 +/- 0.05, P < 0.001), and an increase in the CVI (1.24 +/- 0.03 to 1.29 +/- 0.03, P < 0.01). These results suggest improvements in acute cardiac autonomic modulation following a single bout of IHG. This may be mechanistically linked to the observed reductions in ABP seen in previous IHG training studies. Alternatively, these acute effects may have clinical applications and require further investigation.

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“…The cardiac vagal tone reflects vagotonia and CV fitness and importantly was found to correlate with HR recovery, another prognostic indicator thought to partially reflect vagal activity. 18,19 The authors postulated that a brisk HR rise reflects the rapid removal of vagal tone, not the early application of sympathetic activity. This hypothesis is supported by pharmacological experiments in which blockade of the parasympathetic system with atropine blunts the cardiac vagal tone, whereas inhibition of the sympathetic system with propranolol fails to suppress the HR rise in this exercise interval.…”

Section: Figurementioning

confidence: 99%

Prognostic Value of Heart Rate Increase at Onset of Exercise Testing

et al. 2007

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Background-The initial response of heart rate to dynamic exercise has been proposed as having prognostic value in limited studies that have used modalities other than the treadmill. Our aim was to evaluate the prognostic value of early heart rate parameters in patients referred for routine clinical treadmill testing. Methods and Results-The heart rate rise at the onset of exercise was measured in 1959 patients referred for clinical treadmill testing at the Palo Alto (Calif) Veterans Affairs Medical Center from 1997 to 2004. Multivariable Cox survival analysis was performed for 197 all-cause and 74 cardiovascular deaths that accrued during a mean follow-up of 5.4Ϯ2.1 years. Decreased heart rate changes at all initial relative exercise workloads were associated with significantly increased all-cause mortality. The heart rate rise at one-third total exercise capacity, however, was the only early heart rate variable that significantly predicted both all-cause and cardiovascular risk after adjustment for confounders. Failing to reach 1 SD in the heart rate rise at one-third total exercise capacity was associated with a 28% increased all-cause mortality rate (hazard ratio, 0.72; 95% CI, 0.61 to 0.85; PϽ0.001) and a 35% cardiovascular mortality rate (hazard ratio, 0.65; 95% CI, 0.49 to 0.86; Pϭ0.003). Of all heart rate measurements considered (initial and recovery), the heart rate increase at peak exercise was the most powerful predictor of cardiovascular prognosis after adjustment for potential confounders. The Duke treadmill score, however, was superior to all heart rate measurements in the prediction of cardiovascular mortality. Conclusions-In the present study population, a rapid initial heart rate rise was associated with improved survival, but the heart rate increase at peak exercise and other conventional measurements such as exercise capacity and the Duke treadmill score were more powerful predictors of prognosis.

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Electrocardiographic criteria for vagotonia—validation with pharmacological parasympathetic blockade in healthy subjects

Cited by 29 publications

References 28 publications

Respostas hemodinâmicas a um protocolo de treinamento isométrico de preensão manual

Respostas hemodinâmicas a um protocolo de treinamento isométrico de preensão manual

Isometric handgrip exercise improves acute neurocardiac regulation

Prognostic Value of Heart Rate Increase at Onset of Exercise Testing

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