Electrocardiographic findings following intravenous glycopyrrolate to sedated dogs: a comparison with atropine

Richards, Dana; Clutton, R. E.; Boyd, Christie

doi:10.1111/j.1467-2995.1989.tb00071.x

Cited by 16 publications

(19 citation statements)

References 27 publications

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“…Disadvantages of using atropine are short duration of action, especially if given intravenously, tachycardia and arrhythmias (Richards and others 1989). In paediatric human patients, the use of glycopyrrolate has been suggested as a preferable alternative to atropine as it induces less sinus tachycardia; in fact, when tachycardia is too pronounced, ventricular filling is limited and myocardial oxygen consumption is increased (Jones 2016).…”

Section: Discussionmentioning

confidence: 99%

Severe bradycardia after hypoxaemia and endotracheal intubation and cardiac arrest following glycopyrrolate in a dog

Scarabelli

Rigotti

Alderson

2017

Vet Record Case Reports

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A nine-year-old neutered male Yorkshire terrier with history of chronic cough underwent bronchoscopy and bronchoalveolar lavage; general anaesthesia was maintained with a variable rate infusion of propofol, and oxygen was insufflated via a urinary catheter in the trachea. At the end of the procedure, desaturation occurred; endotracheal intubation was performed and was immediately followed by severe bradycardia and respiratory arrest. Glycopyrrolate (5 µg/kg) was administered leading to cardiac arrest. Apnoea and asystole were quickly treated with manual positive pressure ventilation, external chest compressions and intravenous administration of 0.04 mg/kg of atropine. This case describes vagally induced bradycardia after intubation, possible predisposing factors and its treatment/prevention with antimuscarinic drugs.

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Section: Discussionmentioning

confidence: 99%

Severe bradycardia after hypoxaemia and endotracheal intubation and cardiac arrest following glycopyrrolate in a dog

Scarabelli

Rigotti

Alderson

2017

Vet Record Case Reports

View full text Add to dashboard Cite

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“…Significant bradycardias have been reported associated with the administration of low doses of anticholinergic drugs (Richards et al. ; Rishniw et al. ).…”

Section: Introductionmentioning

confidence: 99%

“…Unwanted tachycardias may also occur after the administration of anticholinergic drugs (Richards et al. ; Rishniw et al. ; Dyson & James‐Davies ).…”

Section: Introductionmentioning

confidence: 99%

“…In normal dogs with experimentally induced vagally mediated bradycardia (induced by opioid administration), a single administration of atropine (0.02 mg kg À1 ) failed to resolve the bradycardia in two out of seven dogs (Rishniw et al 1996). Significant bradycardias have been reported associated with the administration of low doses of anticholinergic drugs (Richards et al 1989;Rishniw et al 1996). Unwanted tachycardias may also occur after the administration of anticholinergic drugs (Richards et al 1989;Rishniw et al 1996;Dyson & James-Davies 1999).…”

Section: Introductionmentioning

confidence: 99%

“…Significant bradycardias have been reported associated with the administration of low doses of anticholinergic drugs (Richards et al 1989;Rishniw et al 1996). Unwanted tachycardias may also occur after the administration of anticholinergic drugs (Richards et al 1989;Rishniw et al 1996;Dyson & James-Davies 1999). Transvenous and transthoracic pacing are options for these patients, but these have limitations, as previously discussed.…”

Section: Introductionmentioning

confidence: 99%

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