Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort

Bourré‐Tessier, Josiane; Urowitz, Murray B.; Clarke, Ann E.; Bernatsky, Sasha; Krantz, Mori J.; Huynh, Thao; Joseph, Lawrence; Bélisle, Patrick; Bae, Sang Cheol; Hanly, John G.; Wallace, Daniel J.; Gordon, Caroline; Isenberg, David; Rahman, Anisur; Gladman, Dafna D.; Fortin, Paul R.; Merrill, Joan T.; Romero-Díaz, Juanita; Sánchez‐Guerrero, Jorge; Fessler, Barri J.; Alarcón, Graciela S.; Steinsson, Kristján; Bruce, Ian N.; Ginzler, Ellen M.; Dooley, Mary Anne; Nived, Ola; Sturfelt, Gunnar; Kalunian, Kenneth C.; Ramos‐Casals, Manuel; Petri, Michelle; Zoma, Asad; Pineau, Christian

doi:10.1002/acr.22370

Cited by 45 publications

(45 citation statements)

References 34 publications

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“…We and 88% of the patients were females (8). Therefore, the results of these studies are consistent with each other, which is due to the increased incidence of lupus among women at the peak of their childbearing age.…”

Section: Discussionsupporting

confidence: 84%

“…Abnormal repolarization is usually revealed by a prolonged modified QT interval. These ECG abnormalities are associated with an increased risk of cardiac arrhythmias and sudden cardiac death (7,8). The early diagnosis of these abnormalities and electrocardiographic abnormalities may be of prognostic value, playing an important role in determining the prognosis of the disease (8).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Relationship Between Dose and Number of Effective Used Drugs on on QT Interval in Patients with Lupus

et al. 2020

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Background: Systemic lupus erythematosus is an autoimmune and multi-organ disease. Cardiovascular involvement is one of most important causes of death in these patients. In some studies, it has been observed that the prolongation of the QTc interval is a prognostic factor in cardiovascular failure. Objectives: In this study, we intended to assess the role of drugs used in treating patients with lupus on the prolonged QTc interval. Methods: This descriptive-analytical study was carried out on 150 patients with SLE referring to Rheumatology Clinics in the City of Arak during 2014 and 2015. Then, ECGs were taken from all patients in two phases, first on admission and second six hours later. The QTc interval was determined using Bazett's formula. The results were analyzed using SPSS version 16 software. Results: The mean age of the studied patients was 35.36 ± 11.8 years and 80.7% were females. An anti-Ro/SSA antibody and treatment with hydroxychloroquine were significantly associated with the prolongation of QTc in patients; however, the duration and dosage of hydroxychloroquine did not affect the QTc interval. Conclusions: Based on the obtained results, hydroxychloroquine may influence the cardiac condition of patients; thus, it needs more studies in this field.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Assessment of the Relationship Between Dose and Number of Effective Used Drugs on on QT Interval in Patients with Lupus

et al. 2020

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“…26 Although the study of cardiac conduction defects in SLE had been limited primarily to neonatal lupus in association with anti-SSA/Ro antibodies,27 a recent study that evaluated the prevalence of ECG abnormalities in an inception SLE adult cohort found that 31% of patients had non-specific ST-T abnormalities and 15% had a prolonged QTc;7 however, no comparison group was included and 74% of the patients were white and Asian. Our study addressed a gap in identifying the prevalence of these ECG abnormalities in a cohort of patients with SLE of mainly Hispanic and black origins, as well as at different clinical stages of the disease and hence with longer disease duration and a higher mean SLEDAI-2K score as compared with the patients studied by Bourré-Tessier et al 7. More importantly, the fact that in our study over half of the patients with SLE had non-specific ST-T abnormalities as compared with only 17% of the older, more male encompassing RA group is striking and underscores the need for evaluations that detect subclinical cardiovascular involvement in SLE.…”

Section: Discussionmentioning

confidence: 99%

“…Although only explored in one recent study, ECG non-specific ST-T abnormalities were reported in 31% of patients with SLE from an inception cohort; additionally, a prolonged corrected QT-interval (QTc) was noted in 15% of patients 7. However, Bourré-Tessier et al lacked a comparison group and the patients consisted of predominantly whites and Asians with mild disease activity.…”

Section: Introductionmentioning

confidence: 99%

ECG non-specific ST-T and QTc abnormalities in patients with systemic lupus erythematosus compared with rheumatoid arthritis

Geraldino‐Pardilla

Gartshteyn

Pina³

et al. 2016

Lupus Sci Med

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ObjectivesCardiovascular disease (CVD) is a leading cause of death in systemic lupus erythematosus (SLE) and in rheumatoid arthritis (RA). Although only explored in one study, ECG non-specific ST-T abnormalities, in addition to corrected QT-interval (QTc) prolongation, were recently reported in an SLE inception cohort. Importantly, these ECG abnormalities are known predictors of CVD mortality in the general population, yet their prevalence in patients with established SLE has not been evaluated.MethodsWe cross-sectionally investigated the presence of non-specific ST-T and QTc abnormalities in 50 patients with SLE, predominantly Hispanic and black, without CVD or SLE-related cardiac involvement and compared them with 139 patients with RA without CVD. Demographics, disease-specific characteristics and CVD risk factors were ascertained and adjusted for.ResultsPatients with SLE (mean age 36±13 years, 92% women, 6 years median disease duration, 96% Hispanics and blacks) had a 3.3-fold higher adjusted prevalence of non-specific ST-T abnormalities (56% vs 17%; p <0.0001) compared with RA, despite the older age and higher percentage of men in the RA group. The QTc was 26 ms longer in SLE compared with RA (p=0.002) in the setting of a higher percentage of women, blacks, Hispanics and higher C reactive protein levels in the SLE group.ConclusionsThis study demonstrates a high prevalence of ECG abnormalities in predominantly Hispanic and black patients with SLE. Longitudinal evaluation of the progression to potentially life-threatening arrhythmias and/or cardiovascular events is warranted.

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“…Bourre Tessier et al 9 analysed the electrocardiographic abnormalities in 779 patients with SLE, describing nonspecific repolarization changes, without association between QTc duration and specificity or level of anti-Ro/SSA antibodies. However, the included patients were characterized by a short duration of disease (10.5 months), without specifically collected data about the cumulative dose of HCQ and possible electrocardiographic changes.…”

Section: Discussionmentioning

confidence: 99%

Cumulative dose of hydroxychloroquine is associated with a decrease of resting heart rate in patients with systemic lupus erythematosus: a pilot study

Cairoli

Danese

Teliz

et al. 2015

Lupus

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Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort

Abstract: Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with

Cited by 45 publications

References 34 publications

Assessment of the Relationship Between Dose and Number of Effective Used Drugs on on QT Interval in Patients with Lupus

Assessment of the Relationship Between Dose and Number of Effective Used Drugs on on QT Interval in Patients with Lupus

ECG non-specific ST-T and QTc abnormalities in patients with systemic lupus erythematosus compared with rheumatoid arthritis

Cumulative dose of hydroxychloroquine is associated with a decrease of resting heart rate in patients with systemic lupus erythematosus: a pilot study

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