Electrocardiographic myocardial infarction without structural lesion in the setting of acute hymenoptera envenomation

Valkanas, Michael A.; Dailey, Michael W.; Bowman, Scott

doi:10.1016/j.ajem.2007.02.046

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Africanised bee envenomation can also cause loss of consciousness and death from hypoxia, hypotension and cardiac collapse [34]. Acute myocardial infarction has been reported in several case reports of patients stung by Africanised bees [35–37].…”

Section: Discussionmentioning

confidence: 99%

Production of Human Antibody Fragments Binding to Melittin and Phospholipase A2 in Africanised Bee Venom: Minimising Venom Toxicity

Funayama

Pucca

Roncolato

et al. 2011

Basic Clin Pharma Tox

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The hybrid created from the crossbreeding of European and African bees, known as the Africanised bee, has provided numerous advantages for current beekeeping. However, this new species exhibits undesirable behaviours, such as colony defence instinct and a propensity to attack en masse, which can result in serious accidents. To date, there is no effective treatment for cases of Africanised bee envenomation. One promising technique for developing an efficient antivenom is the use of phage display technology, which enables the production of human antibodies, thus avoiding the complications of serum therapy, such as anaphylaxis and serum sickness. The aim of this study was to produce human monoclonal single-chain Fv (scFv) antibody fragments capable of inhibiting the toxic effects of Africanised bee venom. We conducted four rounds of selection of antibodies against the venom and three rounds of selection of antibodies against purified melittin. Three clones were selected and tested by enzyme-linked immunosorbent assay to verify their specificity for melittin and phospholipase A2. Two clones (C5 and C12) were specific for melittin, and one (A7) was specific for phospholipase A2. In a kinetic haemolytic assay, these clones were evaluated individually and in pairs. The A7-C12 combination had the best synergistic effect and was chosen to be used in the assays of myotoxicity inhibition and lethality. The A7-C12 combination inhibited the in vivo myotoxic effect of the venom and increased the survival of treated animals.

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Section: Discussionmentioning

confidence: 99%

Production of Human Antibody Fragments Binding to Melittin and Phospholipase A2 in Africanised Bee Venom: Minimising Venom Toxicity

Funayama

Pucca

Roncolato

et al. 2011

Basic Clin Pharma Tox

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“…Rarely, acute coronary syndromes including ST-segment elevation myocardial infarction (STEMI) have been reported after hymenoptera stings (1)(2)(3). The pathophysiology of cardiac ischemia has been attributed to coronary artery vasospasm, although platelet activation and coronary thrombosis also have been reported (2).…”

Section: Introductionmentioning

confidence: 98%

ST Elevation Myocardial Infarction With No Structural Lesions After a Wasp Sting

Rekik

Andrieu

Aboukhoudir

et al. 2012

The Journal of Emergency Medicine

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“…3 Although in the majority of Kounis syndrome cases acute coronary syndrome is associated with a systemic allergic reaction, Kounis syndrome might also occur in patients without any signs of anaphylaxis. 1,4 Although no generalised or local allergy symptoms occurred, except swelling of the head, the development of MI after a bee sting suggests Kounis syndrome. Widespread lesions in the coronary arteries were consistent with type 2 Kounis syndrome.…”

Section: Dear Editormentioning

confidence: 99%

Acute myocardial infarction triggered by bee sting

Arıbaş

Akıllı

Aribas

et al. 2013

Emerg Medicine Australasia

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Electrocardiographic myocardial infarction without structural lesion in the setting of acute hymenoptera envenomation

Cited by 6 publications

References 6 publications

Production of Human Antibody Fragments Binding to Melittin and Phospholipase A2 in Africanised Bee Venom: Minimising Venom Toxicity

Production of Human Antibody Fragments Binding to Melittin and Phospholipase A2 in Africanised Bee Venom: Minimising Venom Toxicity

ST Elevation Myocardial Infarction With No Structural Lesions After a Wasp Sting

Acute myocardial infarction triggered by bee sting

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