Electrocatalytic detection of ethanol and acetaldehyde by aminoxyl radicals: utilizing molecular catalysis for breath analysis

Mayer, Mikayla N.; Rafiee, Mohammad

doi:10.1039/d2an00927g

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…In patients with persistent heart failure, lower amounts of isoprene have been discovered [ 225 ]. After cardiopulmonary bypass and in ischemic heart disease [ 30 , 226 ], increased exhaled n-alkane concentrations have been observed in the patient's breath. Increased concentrations of n-alkanes have been observed in the exhaled breath of patients with myocardial infarction [ 227 ].…”

Section: Vocs Identified In Various Diseasesmentioning

confidence: 99%

“…Another reason for which exhaled breath analysis and related VOCs are receiving much attention in the scientific, clinical, and research communities is because of their ability to examine biochemical processes in the human body in real time without being invasive, and they can also be carried out often under any circumstances, such as during surgery or in intensive care units [13,18,[22][23][24][25][26][27][28][29][30][31][32]. Unlike blood and urine, breath samples have the advantage of having an unlimited supply of samples, which might be collected in time frames as little as seconds and on demand for as long as needed.…”

Section: Introductionmentioning

confidence: 99%

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Smelling the Disease: Diagnostic Potential of Breath Analysis

2023

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Breath analysis is a relatively recent field of research with much promise in scientific and clinical studies. Breath contains endogenously produced volatile organic components (VOCs) resulting from metabolites of ingested precursors, gut and air-passage bacteria, environmental contacts, etc. Numerous recent studies have suggested changes in breath composition during the course of many diseases, and breath analysis may lead to the diagnosis of such diseases. Therefore, it is important to identify the disease-specific variations in the concentration of breath to diagnose the diseases. In this review, we explore methods that are used to detect VOCs in laboratory settings, VOC constituents in exhaled air and other body fluids (e.g., sweat, saliva, skin, urine, blood, fecal matter, vaginal secretions, etc.), VOC identification in various diseases, and recently developed electronic (E)-nose-based sensors to detect VOCs. Identifying such VOCs and applying them as disease-specific biomarkers to obtain accurate, reproducible, and fast disease diagnosis could serve as an alternative to traditional invasive diagnosis methods. However, the success of VOC-based identification of diseases is limited to laboratory settings. Large-scale clinical data are warranted for establishing the robustness of disease diagnosis. Also, to identify specific VOCs associated with illness states, extensive clinical trials must be performed using both analytical instruments and electronic noses equipped with stable and precise sensors.

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Section: Vocs Identified In Various Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Smelling the Disease: Diagnostic Potential of Breath Analysis

2023

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“…Furthermore, immobilisation of a TEMPO polymer at an electrode surface can dramatically improve its electroactivity towards alcohol oxidation, relative to its non-immobilized homogeneous form [9]. This immobilisation strategy has been exploited by many researchers to prepare modified electrodes for the electrocatalytic conversion of alcohols to aldehydes and ketones [10,11] and in the development of non-enzymatic amperometric sensors for alcohol and glucose detection [12][13][14]. The TEMPO polymers utilised in such studies, though, are normally obtained through multi-step synthetic procedures, thus limiting their wider application.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical alcohol oxidation using a TEMPO nitroxide polymer as a homogeneous and surface‐confined catalyst

Place,

Kavanagh

2024

Electroanalysis

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Polymers containing TEMPO moieties are effective catalysts for the electrochemical oxidation of alcohols. Such polymers, almost exclusively, are non‐commercial and are prepared using multi‐step synthetic procedures. Here we show that a commercially available TEMPO bearing polymer, Polyamine Immobilised Piperidinyl Oxyl (PIPO), is an effective homogeneous and surface‐confined polymeric catalyst for electrochemical alcohol oxidation at carbonaceous electrodes. We probe electrolytic conditions for effective and stable electrocatalytic alcohol oxidation showing that dichloromethane (DCM), containing tetrabutylammonium perchlorate (TBAP) and N‐methyl imidazole (NMI), is a suitable medium for homogeneous catalysis whilst carbonate buffer (pH 9.5) is better suited when PIPO is adsorbed at the electrode surface. These findings demonstrate the viability of PIPO as an effective and accessible catalyst for electrochemical alcohol oxidations.

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Fluorescence Quenching Effect of a Highly Active Nitroxyl Radical on 7-amino-4-methylcoumarin and Glutathione Sensing

Sugiyama,

Sakurai,

Sato

et al. 2024

J Fluoresc

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Electrocatalytic detection of ethanol and acetaldehyde by aminoxyl radicals: utilizing molecular catalysis for breath analysis

Abstract: Herein, the insights gleaned from mechanistic studies of aminoxyl catalyzed oxidation of alcohols and aldehydes were used for fabrication of a gas phase sensor for ethanol and acetaldehyde. This electrochemical...

Cited by 6 publications

References 26 publications

Smelling the Disease: Diagnostic Potential of Breath Analysis

Smelling the Disease: Diagnostic Potential of Breath Analysis

Electrochemical alcohol oxidation using a TEMPO nitroxide polymer as a homogeneous and surface‐confined catalyst

Fluorescence Quenching Effect of a Highly Active Nitroxyl Radical on 7-amino-4-methylcoumarin and Glutathione Sensing

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