Electrocatalytic quantification of antiviral drug valacyclovir

Abstract

GRP-Bi 2 O 3 /GCE (graphene/bismuth oxide/glassy carbon electrode) nanocomposite is proposed as a sensor for the rapid, sensitive and highly selective voltammetric determination of valacyclovir (VCV) by cyclic voltammetry (CV) and square wave voltammetry (SWV). The scanning electron microscopy (SEM), atomic force microscopy (AFM) and X-ray diffraction (XRD) techniques were applied to characterize the structure and properties of the nanocomposites. The anodic current of VCV is enhanced by about 2 times using a GRPBi 2 O 3 /GCE sensor. The GRP-Bi 2 O 3 /GCE shows an excellent electrocatalytic activity towards the oxidation of VCV in Britton-Robinson buffer at pH 10.5. The resulting GRPBi 2 O 3 /GCE sensor offers an excellent detection for VCV at 0.926 V with a linear response range of 100-700 ng/mL and correlation coefficient of 0.9994. The simple and fast fabrication of the sensor makes it superior to other techniques, which have been applied to detect VCV.

Potentiometric Sensing of Valaciclovir Hydrochloride in the Presence of Its Acid Induced Degradation Product with Real Time Acquisition of the Dissolution Profile from Its Pharmaceutical Formulations

“…These methods include visible spectrophotometric methods, spectrofluorimetric methods, high performance liquid chromatographic methods, thin layer chromatographic methods and electrochemical methods that were developed for the determination of VAL in pharmaceutical dosage form, blood samples and biological fluids. [19][20][21][22][23][24][25][26][27][28] Some of these methods depends on single-walled carbon nanotubemodified glassy carbon electrodes, [19][20][21] carbosital electrode, 22 cyclic, differential pulse and square wave voltammetry [23][24][25][26][27] and other methods using two-dimensional graphene nanosheets for the simultaneous detection of acetaminophen and VAL. 28 However, to the most recent collected data, no any reported methods investigated the use of ISE potentiometric method for the determination of VAL in existence of its acid induced degradation product, GUA.…”