Electrochemical activity of glassy carbon electrode modified with ZnO nanoparticles prepared Via Senna Alata L. leaf extract towards antiretroviral drug

Abstract

The phytosynthesis method was used to prepare ZnO nanoparticles (ZnO NPs) via Senna alata L. leaf extract (SALE) by involving alkaloids, which play an essential role as a source of weak bases during the formation reaction of NPs. ZnO NPs on glassy carbon electrodes (GCE/ZnO NP) have been introduced to investigate its electrochemical activity towards the antiretroviral drug, lamivudine (3TC). Several characterization techniques, such as Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDS), and Dynamic Light Scattering (DLS) techniques were employed to analyze the properties of GCE/ZnO NPs. As a result, ZnO NPs in spherical shape showed a high purity crystalline hexagonal wurtzite structure with a particle diameter of 40–60 nm. A Cyclic Voltammetry (CV) measurement confirmed that the electrochemical reduction of 3TC on GCE/ZnO NPs exhibited an excellent linear range of 10–300 µM with a detection limit of 1.902 µM, quantitation limit of 6.330 µM, and sensitivity of 0.0278 µA/µM. Thus, this research suggests a facile method for the preparation of material-based ZnO NPs as a promising antiretroviral drug sensors due to their excellent electrochemical properties.

Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract

“…In both the shellac and extract, C-H stretching absorption took place at 2928 cm −1 and 2856 cm −1 , and 2919 cm −1 and 2850 cm −1 , respectively. The identification of distinct peaks in the bleached shellac and extract was in accordance with findings reported in the literature [18,[57][58][59][60][61].…”

“…At 3400 cm −1 and cm −1 , respectively, the shellac and extract exhibited prominent peaks that were ascrib the O-H stretching vibration, which signifies the presence of OH functional group both the shellac and extract, C-H stretching absorption took place at 2928 cm −1 and cm −1 , and 2919 cm −1 and 2850 cm −1 , respectively. The identification of distinct peaks i bleached shellac and extract was in accordance with findings reported in the liter [18,[57][58][59][60][61].…”