Electrochemical and Fluorescent Properties of Crown Ether Functionalized Graphene Quantum Dots for Potassium and Sodium Ions Detection

Iannazzo, Daniela; Espro, Claudia; Ferlazzo, Angelo; Celesti, Consuelo; Branca, C.; Neri, G.

doi:10.3390/nano11112897

Cited by 31 publications

(19 citation statements)

References 50 publications

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“…GO has been applied in many fields [ 84 ], such as fluorescence imaging [ 16 ], luminescence carriers [ 85 ], sensing matrices [ 20 ], biosensing [ 86 , 87 ], disease detection [ 88 ], drug carriers [ 89 ], ion detection [ 90 ], fluorescent probing [ 91 ], etc., due to its excellent PL properties. In this section, the PL of GO, GQDs, and GOQDs in electronic devices and biomedical fields will be emphatically introduced.…”

Section: Applications Of Go Gqds and Goqds Luminescencementioning

confidence: 99%

Photoluminescence and Fluorescence Quenching of Graphene Oxide: A Review

Xiao

Zhou

et al. 2022

Nanomaterials

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In recent decades, photoluminescence (PL) material with excellent optical properties has been a hot topic. Graphene oxide (GO) is an excellent candidate for PL material because of its unique optical properties, compared to pure graphene. The existence of an internal band gap in GO can enrich its optical properties significantly. Therefore, GO has been widely applied in many fields such as material science, biomedicine, anti-counterfeiting, and so on. Over the past decade, GO and quantum dots (GOQDs) have attracted the attention of many researchers as luminescence materials, but their luminescence mechanism is still ambiguous, although some theoretical results have been achieved. In addition, GO and GOQDs have fluorescence quenching properties, which can be used in medical imaging and biosensors. In this review, we outline the recent work on the photoluminescence phenomena and quenching process of GO and GOQDs. First, the PL mechanisms of GO are discussed in depth. Second, the fluorescence quenching mechanism and regulation of GO are introduced. Following that, the applications of PL and fluorescence quenching of GO–including biomedicine, electronic devices, material imaging–are addressed. Finally, future development of PL and fluorescence quenching of GO is proposed, and the challenges exploring the optical properties of GO are summarized.

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Section: Applications Of Go Gqds and Goqds Luminescencementioning

confidence: 99%

Photoluminescence and Fluorescence Quenching of Graphene Oxide: A Review

Xiao

Zhou

et al. 2022

Nanomaterials

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“…Potassium ions are electrolytes essential for homeostasis in the body. Real-time tracking of potassium concentrations in body fluids can provide important information for biomedical diagnosis, assessment of therapeutic interventions and optimization of exercise performance [ 157 , 158 ]. Chen et al combined NaYF 4 : Yb, Tm (U-Tm, blue emission) and NaYF 4 : Yb, Er (U-Er, green emission) UCNPs with AuNP quenchers to construct two DNA-assembled nanosensors for monitoring H + and K + in the lumen of lysosomes.…”

Section: Ucnps In Analytical Application Of Biosciencementioning

confidence: 99%

A Comprehensive Review on Upconversion Nanomaterials-Based Fluorescent Sensor for Environment, Biology, Food and Medicine Applications

Jiang

et al. 2022

Biosensors

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Near-infrared-excited upconversion nanoparticles (UCNPs) have multicolor emissions, a low auto-fluorescence background, a high chemical stability, and a long fluorescence lifetime. The fluorescent probes based on UCNPs have achieved great success in the analysis of different samples. Here, we presented the research results of UCNPs probes utilized in analytical applications including environment, biology, food and medicine in the last five years; we also introduced the design and construction of upconversion optical sensing platforms. Future trends and challenges of the UCNPs used in the analytical field have also been discussed with particular emphasis.

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“…Among the different classes of NP, carbon-based nanomaterials possessing a graphene structure, such as graphene oxide, carbon nanotubes, fullerenes and graphene quantum dots, have shown great potential in cancer diagnosis and treatment [ 16 , 17 , 18 , 19 , 20 , 21 ]. The presence of many active groups on the surface of these graphene-based nanomaterials (GBM) allows their multimodal conjugation with biocompatible polymers, drugs and targeting ligands (TL), making them ideal nanocarriers for anticancer therapy [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy

Iannazzo

Celesti²,

Espro³

et al. 2022

Pharmaceutics

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Cancer-targeted drug delivery systems (DDS) based on carbon nanostructures have shown great promise in cancer therapy due to their ability to selectively recognize specific receptors overexpressed in cancer cells. In this paper, we have explored a green route to synthesize nanobiochar (NBC) endowed with graphene structure from the hydrothermal carbonization (HTC) of orange peels and evaluated the suitability of this nanomaterial as a nanoplatform for cancer therapy. In order to compare the cancer-targeting ability of different widely used targeting ligands (TL), we have conjugated NBC with biotin, riboflavin, folic acid and hyaluronic acid and have tested, in vitro, their biocompatibility and uptake ability towards a human alveolar cancer cell line (A549 cells). The nanosystems which showed the best biological performances—namely, the biotin- and riboflavin- conjugated systems—have been loaded with the poorly water-soluble drug DHF (5,5-dimethyl-6a-phenyl-3-(trimethylsilyl)-6,6a-dihydrofuro[3,2-b]furan-2(5H)-one) and tested for their anticancer activity. The in vitro biological tests demonstrated the ability of both systems to internalize the drug in A549 cells. In particular, the biotin-functionalized NBC caused cell death percentages to more than double with respect to the drug alone. The reported results also highlight the positive effect of the presence of oxygen-containing functional groups, present on the NBC surface, to improve the water dispersion stability of the DDS and thus make the approach of using this nanomaterial as nanocarrier for poorly water-soluble drugs effective.

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Electrochemical and Fluorescent Properties of Crown Ether Functionalized Graphene Quantum Dots for Potassium and Sodium Ions Detection

Cited by 31 publications

References 50 publications

Photoluminescence and Fluorescence Quenching of Graphene Oxide: A Review

Photoluminescence and Fluorescence Quenching of Graphene Oxide: A Review

A Comprehensive Review on Upconversion Nanomaterials-Based Fluorescent Sensor for Environment, Biology, Food and Medicine Applications

Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy

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