Electrochemical and Spectral studies on the Interaction of the Antiparasitic Drug Nitazoxanide with DNA

Detection of DNA utilizing a fluorescent reversible change of a biosensor based on the electron transfer from quantum dots to polymyxin B sulfate

“…The development of novel effective probes for the detection of DNA and the interactions of drugs with DNA have been the focuses, on account of they may be conducive to realizing the effective mechanism of drugs and the design of new specific DNA-targeted drugs [1][2][3]. DNA with their evenly stacked base pairs and shallow (minor) and deep (major) grooves are attractive targets for some drug molecules.…”

Polyaniline–DNA based sensor for the detection of anthracycline drugs

“…Three strategies are utilized for electrochemical detection of antitumor drugs, i.e., (i) recording oxidation of guanine (and to a less extent adenine) residues in the DNA strand [9][10][11][12]; (ii) detecting signal referred to electrochemically active drug affected by interaction with DNA [13][14][15][16]; and (iii) monitoring changes in the surface layer morphology followed by alteration of its permeability and charge transfer resistance [17][18][19][20].…”

Synthesis, characterization, molecular modeling, and DNA interaction studies of a Cu(II) complex containing drug of chronic hepatitis B: adefovir dipivoxil

“…The binding mode of the complex with ct-DNA was investigated using electronic absorption spectra [36]. Binding of a complex with DNA via intercalation generally results in hypochromism and a red-shift of the absorption band (bathochromic effect) because of strong interaction between the ligand and the base pairs of the DNA [37,38]. In groove binding between DNA and small molecules, hyperchromism can be observed, while the position of the absorption almost does not change, which can be associated with degradation of the DNA double-helix structure [39,40].…”