Electrochemical anomalies of protic ionic liquid – Water systems: A case study using ethylammonium nitrate – Water system

Abe, Hiroshi; Nakama, Kazuya; Hayashi, Ryotaro; Aono, Masami; Takekiyo, Takahiro; Yoshimura, Yukihiro; Saihara, Koji; Shimizu, Akio

doi:10.1016/j.chemphys.2016.07.009

Cited by 13 publications

(6 citation statements)

References 30 publications

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“…Thus, the ethylammonium nitrate−water system demonstrated electrochemical instabilities in the intermediate state between IL and bulk water (70−90% water in the system). 748 All of these data support the idea of water being a mediator of at least some effects imposed by ILs on proteins. The ability of ILs to stabilize protein molecules may be generally systemized similarly to small ions of the traditional salts.…”

Section: Ionic Liquids In Drug Synthesismentioning

confidence: 53%

“…Interestingly, water–IL systems demonstrate electrochemical anomalies, which depend on the amount of water. Thus, the ethylammonium nitrate–water system demonstrated electrochemical instabilities in the intermediate state between IL and bulk water (70–90% water in the system) . All of these data support the idea of water being a mediator of at least some effects imposed by ILs on proteins.…”

Section: Chemical Applications Of Ionic Liquids In Pharmacymentioning

confidence: 99%

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Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the form of ionic liquid species. The main aim of this Review is to attract a broad audience of chemical, biological, and medical scientists to study advantages of ionic liquid pharmaceutics. Overall, the discussed data highlight the importance of the research direction defined as "Ioliomics", studies of ions in liquids in modern chemistry, biology, and medicine.

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Section: Ionic Liquids In Drug Synthesismentioning

confidence: 53%

Section: Chemical Applications Of Ionic Liquids In Pharmacymentioning

confidence: 99%

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

2017

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“…Despite its intriguing properties, EAN suffers from poor thermal stability 9 owing to the relatively low DpK a 10, 11 and electrochemical instability in EAN-water binary mixtures due to the unstable nature of the anion. 12 However, beyond EAN and related combinations, further research has been hindered by the scarcity of room temperature liquid samples (or even low melting temperature salts). 3 Incorporation of more weakly Lewis-basic anions has opened new opportunities for alkylamine-based PILs, in particular for tertiary amines, and also for secondary amines.…”

Section: Introductionmentioning

confidence: 99%

Protic ionic liquids with primary alkylamine-derived cations: the dominance of hydrogen bonding on observed physicochemical properties

et al. 2018

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“…The addition of classic salt cosolutes and/or organic cosolvents leads to various effects on Pluronic micellization, depending on the change of solvent quality. While the ionic liquid EAN exhibits interesting and useful properties when mixed with water [ 46 ], the lack of research on PEO-PPO-PEO micellization in aqueous EAN solutions leaves a gap in our fundamental knowledge of this self-assembly process. Quantifying the effect of EAN on PEO-PPO-PEO micellization in aqueous solution in terms of thermodynamics and interactions merits further work.…”

Section: Introductionmentioning

confidence: 99%

Micellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions

Alexandridis

2017

Polymers

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Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers (commercially available as Pluronics or Poloxamers) can self-assemble into various nanostructures in water and its mixtures with polar organic solvents. Ethylammonium nitrate (EAN) is a well-known protic ionic liquid that is expected to affect amphiphile self-assembly due to its ionic nature and hydrogen bonding ability. By proper design of isothermal titration calorimetry (ITC) experiments, we determined the enthalpy and other thermodynamic parameters of Pluronic P123 (EO 20 PO 70 EO 20 ) micellization in aqueous solution at varied EAN concentration. Addition of EAN promoted micellization in a manner similar to increasing temperature, e.g., the addition of 1.75 M EAN lowered the critical micelle concentration (CMC) to the same extent as a temperature increase from 20 to 24 • C. The presence of EAN disrupts the water solvation around the PEO-PPO-PEO molecules through electrostatic interactions and hydrogen bonding, which dehydrate PEO and promote micellization. At EAN concentrations lower than 1 M, the PEO-PPO-PEO micellization enthalpy and entropy increase with EAN concentration, while both decrease above 1 M EAN. Such a change can be attributed to the formation by EAN of semi-ordered nano-domains with water at higher EAN concentrations. Pyrene fluorescence suggests that the polarity of the mixed solvent decreased linearly with EAN addition, whereas the polarity of the micelle core remained unaltered. This work contributes to assessing intermolecular interactions in ionic liquid + polymer solutions, which are relevant to a number of applications, e.g., drug delivery, membrane separations, polymer electrolytes, biomass processing and nanomaterial synthesis.

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Electrochemical anomalies of protic ionic liquid – Water systems: A case study using ethylammonium nitrate – Water system

Cited by 13 publications

References 30 publications

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine

Protic ionic liquids with primary alkylamine-derived cations: the dominance of hydrogen bonding on observed physicochemical properties

Micellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions

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