Electrochemical Aptasensors for Food and Environmental Safeguarding: A Review

Mishra, Geetesh K.; Sharma, Vinay S.; Mishra, Rupesh Kumar

doi:10.3390/bios8020028

Cited by 105 publications

(62 citation statements)

References 51 publications

(56 reference statements)

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“…To date, electrochemical biosensors have enabled sample preparation-free detection of pathogens in various matrices, in situ detection of pathogens on surfaces, rapid pathogen detection using low-cost platforms, multiplexed detection of pathogens in practical matrices, and detection of pathogens via wireless actuation and data acquisition formats. As a result, electrochemical biosensors for pathogen detection have been widely examined for food and water safety, medical diagnostic, environmental monitoring, and bio-threat applications (Amiri et al 2018;Duffy and Moore, 2017;Felix and Angnes, 2018;Furst and Francis, 2019;Mishra et al 2018;Monz� o et al 2015;Rastogi and Singh, 2019).…”

Section: Introductionmentioning

confidence: 99%

Electrochemical biosensors for pathogen detection

Cesewski

Johnson

2020

Biosensors and Bioelectronics

635

358

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A B S T R A C TRecent advances in electrochemical biosensors for pathogen detection are reviewed. Electrochemical biosensors for pathogen detection are broadly reviewed in terms of transduction elements, biorecognition elements, electrochemical techniques, and biosensor performance. Transduction elements are discussed in terms of electrode material and form factor. Biorecognition elements for pathogen detection, including antibodies, aptamers, and imprinted polymers, are discussed in terms of availability, production, and immobilization approach. Emerging areas of electrochemical biosensor design are reviewed, including electrode modification and transducer integration. Measurement formats for pathogen detection are classified in terms of sample preparation and secondary binding steps. Applications of electrochemical biosensors for the detection of pathogens in food and water safety, medical diagnostics, environmental monitoring, and bio-threat applications are highlighted. Future directions and challenges of electrochemical biosensors for pathogen detection are discussed, including wearable and conformal biosensors, detection of plant pathogens, multiplexed detection, reusable biosensors for process monitoring applications, and low-cost, disposable biosensors.

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Section: Introductionmentioning

confidence: 99%

Electrochemical biosensors for pathogen detection

Cesewski

Johnson

2020

Biosensors and Bioelectronics

635

358

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“…Electrochemical methods are low‐cost, sensitive, selective, and portable analytical techniques that are widely used in the environmental, agricultural, medical, and food fields . Most electrochemical sensors have two parts, the biological recognition part and the transducer part, which can capture target analytes and convert biological signals into electric signals, respectively .…”

Section: State‐of‐the‐art Protocols For High‐quality Mirna Detectionmentioning

confidence: 99%

“…Electrochemical methods are low-cost, sensitive, selective, and portable analytical techniques that are widely used in the environmental, agricultural, medical, and food fields. [53][54][55][56] Most electrochemical sensors have two parts, the biological recognition part and the transducer part, which can capture target analytes and convert biological signals into electric signals, respectively. [57] According to the method used for obtaining the electrochemical signal, the electrochemical methods for detecting miRNA can be divided into amperometric and voltammetric measurements, differential pulse voltammetry (DPV), electrochemiluminescence (ECL), electrochemical impedance spectroscopy (EIS), and other methods.…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Progress in miRNA Detection Using Graphene Material–Based Biosensors

Zhang

Miao

Sun

et al. 2019

Small

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MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that play critical roles in physiologic and pathologic processes and are vital biomarkers for several disease diagnostics and therapeutics. Therefore, rapid, low‐cost, sensitive, and selective detection of miRNAs is of paramount importance and has aroused increasing attention in the field of medical research. Among the various reported miRNA sensors, devices based on graphene and its derivatives, which form functional supramolecular nanoassemblies of π‐conjugated molecules, have been revealed to have great potential due to their extraordinary electrical, chemical, optical, mechanical, and structural properties. This Review critically and comprehensively summarizes the recent progress in miRNA detection based on graphene and its derivative materials, with an emphasis on i) the underlying working principles of these types of sensors, and the unique roles and advantages of graphene materials; ii) state‐of‐the‐art protocols recently developed for high‐performance miRNA sensing, including representative examples; and iii) perspectives and current challenges for graphene sensors. This Review intends to provide readers with a deep understanding of the design and future of miRNA detection devices.

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“…This review presents development of aptamers, biosensors, aptasensors for determination of allergen concentration in food matrix. The existing reviews mainly cover development of aptamers for allergens [24], biosensors for food allergens [25], confirmatory methods for allergens [26], and aptasensors for food analysis [27]. The present review is specifically designed to consider the cow milk allergens that can cause life-threatening anaphylactic reactions.…”

Section: Number Of Amino Acids/moleculesmentioning

confidence: 99%

“…Furthermore, the biosensors (e.g., electrochemical and optical biosensors) have the potential to avoid the matrix treatment of via laborious techniques [29], supporting direct, real-time, and label-free detection (in the case of optical biosensors) for milk allergens detection. Furthermore, the use of the aptamers [27,30] and antibodies [31] as recognition element is emphasized to ensure the highly specific and sensitive performance of biosensors for the milk allergens detection. The commercially available biosensors are also summarized here as along with consideration of emerging challenges.…”

Section: Number Of Amino Acids/moleculesmentioning

confidence: 99%

Nano-Biosensing Platforms for Detection of Cow’s Milk Allergens: An Overview

Nehra

Lettieri

Dilbaghi

et al. 2019

Sensors

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Among prevalent food allergies, cow milk allergy (CMA) is most common and may persist throughout the life. The allergic individuals are exposed to a constant threat due to milk proteins’ presence in uncounted food products like yogurt, cheese, and bakery items. The problem can be more severe due to cross-reactivity of the milk allergens in the food products due to homologous milk proteins of diverse species. This problem can be overcome by proper and reliable food labeling in order to ensure the life quality of allergic persons. Therefore, highly sensitive and accurate analytical techniques should be developed to detect the food allergens. Here, significant research advances in biosensors (specifically immunosensors and aptasensors) are reviewed for detection of the milk allergens. Different allergic proteins of cow milk are described here along with the analytical standard methods for their detection. Additionally, the commercial status of biosensors is also discussed in comparison to conventional techniques like enzyme-linked immunosorbent assay (ELISA). The development of novel biosensing mechanisms/kits for milk allergens detection is imperative from the perspective of enforcement of labeling regulations and directives keeping in view the sensitive individuals.

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Electrochemical Aptasensors for Food and Environmental Safeguarding: A Review

Cited by 105 publications

References 51 publications

Electrochemical biosensors for pathogen detection

Electrochemical biosensors for pathogen detection

Progress in miRNA Detection Using Graphene Material–Based Biosensors

Nano-Biosensing Platforms for Detection of Cow’s Milk Allergens: An Overview

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