Electrochemical-based biosensors for microRNA detection: Nanotechnology comes into view

Shabaninejad, Zahra; Yousefi, Fatemeh; Movahedpour, Ahmad; Ghasemi, Younes; Dokanehiifard, Sadat; Rezaei, Samaneh; Aryan, Reihaneh; Mirzaei, Hamed

doi:10.1016/j.ab.2019.113349

Cited by 129 publications

(69 citation statements)

References 127 publications

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“…These molecules exert their effects via targeting a variety of molecular and cellular mechanisms [148][149][150][151][152]. Hence, miRNAs could be used as diagnostic, prognostic and therapeutic biomarkers in the treatment of different diseases such as stroke, cancer, cardiovascular diseases, infection diseases, diabetes, and viral infections [153][154][155][156][157][158][159][160][161][162][163].…”

Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.

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Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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“…CircRNAs are becoming important markers for the diagnosis of these diseases due to their ability to cross the blood-brain barrier and their widespread presence in circulating exosomes (Y. Li et al, 2015;Mohammadi et al, 2020;Naeli et al, 2020;Shabaninejad, Yousefi, et al, 2019).…”

Section: Protein-factor Circularizationmentioning

confidence: 99%

The expanding role of CDR1‐AS in the regulation and development of cancer and human diseases

Azari

Mousavi

Karimi

et al. 2020

Journal Cellular Physiology

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CircRNAs are a superabundant and highly conserved group of noncoding RNAs (ncRNAs) that are characterized by their high stability and integrity compared with linear forms of ncRNAs. Recently, their critical role in gene expression regulation has been shown; thus, it is not far-fetched to believe that their abnormal expression can be a cause of different kinds of diseases such as cancer, neurodegenerative, and autoimmune diseases. They can have a function in variety of biological processes such as microRNA (miRNA) sponging, interacting with RNA-binding proteins, or even an ability to translate to proteins. A huge challenge in finding diagnostic biomarkers is finding noninvasive biomarkers that can be detected in human fluids, especially blood samples. CircRNAs are becoming candidate biomarkers for diagnosis and prognosis of these diseases through their ability to transverse from the blood-brain barrier and their broad presence in circulating exosomes. The circRNA for miRNA-7 (ciRS-7) is newly recognized, and acknowledged to being related to human pathology and cancer progression. In this review, we first briefly summarize the latest studies about their characteristics, biogenesis, and their mechanisms of action in the regulation and development of human diseases. Finally, we provide a list of diseases that are linked to one member of this novel class of ncRNAs called ciRS-7.

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“…More understanding about these signaling pathways could contribute to the design and development of new therapeutic platforms. In this context, epigenetic regulations appeared as key modulators in cancer and CSCs [65][66][67][68][69][70]. MicroRNAs (miRNAs) are one of main epigenetic regulators which act as oncogenes or tumor suppressors [71][72][73][74][75][76][77][78].…”

Section: Diagnosis and Treatment Of Pcmentioning

confidence: 99%

Cancer stem cells as therapeutic targets of pancreatic cancer

Razi

Radak

Mahjoubin‐Tehran

et al. 2019

Fundamemntal Clinical Pharma

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The discovery of stem cells and their potential abilities in self‐renewal and differentiation has opened a new horizon in medicine. Scientists have found a small population of stem cells in some types of cancers with the same functions as normal stem cells. There are two models for tumor progression: clonal (stochastic) and cancer stem cell (CSCs) models. According to the first model, all transformed cells in the tumor have carcinogenic potential and are able to proliferate and produce the same cells. The latter model, which has received more attention recently, considers the role of CSCs in drug resistance and tumor metastasis. Following the model, researchers have found that targeting CSCs may be a promising way in cancer therapy. This review describes CSC characteristics in general, while also focusing on CSC properties in the context of pancreatic cancer.

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Electrochemical-based biosensors for microRNA detection: Nanotechnology comes into view

Cited by 129 publications

References 127 publications

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

The expanding role of CDR1‐AS in the regulation and development of cancer and human diseases

Cancer stem cells as therapeutic targets of pancreatic cancer

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