Electrochemical behavior and in-vitro antimicrobial screening of some thienylazoaryls dyes

Abstract

BackgroundA series of recently reported phenolic azo dyes 7a–e were prepared by coupling the thienyl diazonium sulfate of 3-Amino-4H-benzo[f]thieno[3,4-c](2H)chromen-4-one with selected diversely substituted phenolic and naphtholic derivatives. These compounds were evaluated for their antibacterial and antifungal activities. Furthermore their voltammetric behavior was compared at a glassy carbon electrode.ResultsThe voltammetric behavior of the five recently reported azo dyes has been compared at a glassy carbon electrode. It is shown that the azo dyes 7a–e with a hydroxyl group in the ortho position with respect to the azo bridge give rise to well defined, irreversible peaks for the oxidation and reduction process within a pH range of 2–7. The mechanisms of electrochemical oxidation of compound 7a–c and 7e are proposed. For the hydroxyl-substituted dyes, re-oxidation peaks were obtained in the subsequent scan. The antimicrobial activities of the reported compounds 7a–e along with the entire precursors 1–4 and 6a–e were performed against selected bacterial and fungal species and their activities compared to those of nystatin, griseofulvin and ciprofloxacin used as reference drugs.ConclusionsThe present study showed significant antimicrobial activity of compounds 6d, 7a and 7c,e against the tested microorganisms; this result confirms the antimicrobial potency of azo compounds and some of their precursors.

Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola

“…The inocula of bacteria and yeasts were prepared from overnight cultures as previously described [ 23 ]. Absorbance was read spectrophotometrically at 530 nm and 600 nm for yeasts and bacteria respectively.…”

Efficient synthesis of diversely substituted pyrazolo[1,5-a]pyrimidine derivatives promoted by ultrasound irradiation in water and their antibacterial activities

“…al. [28] reported the antimicrobial activity of a synthesized novel trisazo dye from 3-amino-4H-thieno [3,4-c][1]benzopyran-4one and Bin et. al.…”

Synthesis, characterization, antimicrobial activities and electrochemical behavior of new phenolic azo dyes from two thienocoumarin amines

“…16,17 In a recent work, our group reported the electrochemical behavior of azo compounds containing hydroxyl group located at the ortho position of the azo group. 18 In the present study, we extend our investigations to diazo dyes possessing different substituents in order to evaluate the influence of the substituent on the progress of the redox reactions. Indeed, another work has shown that the type of substituent on the aromatic ring of some azo compounds has an influence on the oxidation-reduction.…”